Advances in metabolic engineering of microorganisms for medium-chain dicarboxylic acids biosynthesis

  • LI Guohui ,
  • MAO Yin
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  • 1(National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University,Wuxi 214122, China)
    2(School of Biotechnology, Jiangnan University, Wuxi 214122, China)

Received date: 2021-06-15

  Revised date: 2021-07-02

  Online published: 2021-11-18

Abstract

As a class of linear saturated organic acids containing two carboxyl groups, medium-chain dicarboxylic acids (MCDs) play an important role as raw materials for the preparation of polymers, rubbers, pharmaceuticals, dyes and other products. However, the current industrial production of MCDs mainly relies on chemical synthesis, which leads to excessive emission of nitrogen oxides. Therefore, it is important to establish an alternative approach based on microbial fermentation to achieve the cleaner production of MCDs. In this review, the most recent research progress of succinic acid, glutaric acid, adipic acid and the medium-chain dicarboxylic acids with more carbon number such as pimelic acid, suberic acid, azelaic acid and sebacic acid are reviewed. The medium chain dicarboxylic acids are introduced from the perspective of application value, traditional production methods and biological synthesis methods, and the future directions of the research are also forecasted.

Cite this article

LI Guohui , MAO Yin . Advances in metabolic engineering of microorganisms for medium-chain dicarboxylic acids biosynthesis[J]. Food and Fermentation Industries, 2021 , 47(20) : 297 -302 . DOI: 10.13995/j.cnki.11-1802/ts.028285

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