Analysis of the effects on cathartic colon alleviation by Bifidobacterium bifidum FGSYC45M3 and its mechanism

  • LI Xinping ,
  • WANG Linlin ,
  • ZHAO Jianxin ,
  • ZHAO Hao ,
  • CHEN Wei ,
  • WANG Gang
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  • (School of Food Science and Technology, Jiangnan University, Wuxi 214122, China)

Received date: 2021-03-11

  Revised date: 2021-03-30

  Online published: 2021-12-16

Abstract

Cathartic colon is an intestinal nerve damage caused by long-term use of stimulating laxatives. Its clinical manifestation is intractable constipation. There is a lack of effective treatment for cathartic colon now. In this study, a mouse model of cathartic colon was established by gavage with senna leaf extract. The effects of constipation relief and colonic nerves repair by Bifidobacterium bifidum FGSYC45M3 were analyzed with this cathartic colon mouse model. Also, the mechanism of these effects was investigated. The results showed that B. bifidum FGSYC45M3 significantly shortened the time of the first black stool and increased the water content of feces. These beneficial effects may be related to the capabilities of FGSYC45M3 in increasing the content of butyric acid in feces, restoring the number of enteric glial cells, elevating the levels of glial cell line-derived neurotrophic factor (GDNF) and acetylcholinesterase (AChE), increasing the number of interstitial cells of Cajal (ICC) in the colon and decreasing the expression level of aquaporins (AQPs). This study provides a probiotic therapy for not only constipation alleviation, but also the intestinal nerves repair, which might alleviate the cathartic colon thoroughly.

Cite this article

LI Xinping , WANG Linlin , ZHAO Jianxin , ZHAO Hao , CHEN Wei , WANG Gang . Analysis of the effects on cathartic colon alleviation by Bifidobacterium bifidum FGSYC45M3 and its mechanism[J]. Food and Fermentation Industries, 2021 , 47(22) : 42 -48 . DOI: 10.13995/j.cnki.11-1802/ts.027319

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