Research progress of photosensitizer mediated photodynamic sterilization in food

  • XIONG Xiaohui ,
  • KONG Jiayi ,
  • ZHANG Shuai ,
  • LI Chen ,
  • CUI Xiaowen
Expand
  • (College of Food and Light Industry, Nanjing Tech University, Nanjing 211800, China)

Received date: 2020-12-31

  Revised date: 2021-03-22

  Online published: 2021-12-16

Abstract

Microbiological contamination of food is a major issue that consumers, regulators and the food industry need to address today. With the improvement of the quality of life, consumers' demands for the sensory and nutritional quality of food have prompted food processors to adopt novel sterilization techniques that do not affect food quality. Photosensitizer mediated photodynamic sterilization is to use the light stimulates the photosensitizer, and then its excited state can be extracted by the first kind of hydrogen atom or electron transfer reaction, or through the second type of energy is transferred to the ground state molecules oxygen (3Σ-g) formation of singlet oxygen (1Δg) and interaction with its surrounding environment effectively. The active substances (free radicals and reactive oxygen species) will lead to bacterial cell oxidative damage and death. By selecting and using suitable photosensitizers and light conditions, photodynamic sterilization technology can effectively kill microorganisms without affecting nutritional and sensory characteristics. This review introduced the principle of photosensitizer mediated photodynamic sterilization and the factors that affect the sterilization effect in food. It also compared the advantages and disadvantages with other sterilization technologies. On this basis, the research and application of different photosensitizer mediated photodynamic sterilization technology in food were summarized, and the prospect of photodynamic sterilization technology was also discussed.

Cite this article

XIONG Xiaohui , KONG Jiayi , ZHANG Shuai , LI Chen , CUI Xiaowen . Research progress of photosensitizer mediated photodynamic sterilization in food[J]. Food and Fermentation Industries, 2021 , 47(22) : 309 -318 . DOI: 10.13995/j.cnki.11-1802/ts.026616

References

[1] PENHA C B, BONIN E, DA SILVA A F, et al.Photodynamic inactivation of foodborne and food spoilage bacteria by curcumin[J].LWT-Food Science and Technology, 2017, 76:198-202.
[2] GHATE V S, NG K S, ZHOU W B, et al.Antibacterial effect of light emitting diodes of visible wavelengths on selected foodborne pathogens at different illumination temperatures[J].International Journal of Food Microbiology, 2013, 166(3):399-406.
[3] PASKEVICIUTE E, ZUDYTE B, LUKSIENE Z.Towards better microbial safety of fresh produce:Chlorophyllin-based photosensitization for microbial control of foodborne pathogens on cherry tomatoes[J].Journal of Photochemistry and Photobiology B:Biology, 2018, 182:130-136.
[4] LOPEZCARBALLO G, HERNANDEZMUNOZ P, GAVARA R, et al.Photoactivated chlorophyllin-based gelatin films and coatings to prevent microbial contamination of food products[J].International Journal of Food Microbiology, 2008, 126(1-2):65-70.
[5] 陈颖慧. 食品杀菌技术概述[J].时代农机, 2017, 44(7): 151-152.
CHEN Y H.Overview of food sterilization technology [J].Times Agricultural Machinery, 2017, 44(7): 151-152.
[6] BHAVYA M L, UMESH H H.Efficacy of blue LED in microbial inactivation:Effect of photosensitization and process parameters[J].International Journal of Food Microbiology, 2019, 290:296-304.
[7] 张艳慧, 胡文忠, 刘程惠, 等.光电杀菌技术在鲜切果蔬保鲜中应用的研究进展[J].食品科学, 2020, 41(15):309-313.
ZHANG Y H, HU W Z, LIU C H, et al.Research progress of application of photoelectrobactericidal technology in fresh-cut fruits and vegetables [J].Food Science, 2020, 41(15):309-313.
[8] LUKSIENE Z, BROVKO L.Antibacterial photosensitization-based treatment for food safety[J].Food Engineering Reviews, 2013, 5(4):185-199.
[9] 赵若晴. 蔬菜汁中金黄色葡萄球菌生长预测模型的构建及光动力杀菌技术研究[D].长春:吉林大学,2020.
ZHAO R Q.Construction of growth prediction model of staphylococcus aureus in vegetable juice and study on photodynamic sterilization technology [D].Changchun:Jilin University, 2020.
[10] 于金珅, 张芳.姜黄素介导的光动力技术对鲜切马铃薯的杀菌效果[J/OL].食品工业科技[2020-07-22].https://kns.cnki.net/kcms/detail/11.1759.TS.20200722.1541.002.html.
YU J S, ZHANG F.The bactericidal effect of curcumin mediated photodynamic technology on fresh-cut potato[J/OL].Science and Technology of Food Industry [2020-07-22].https://kns.cnki.net/kcms/detail/11.1759.TS.20200722.1541.002.html.
[11] 宋坤. 光敏剂—纳米粒载体系统在卵巢癌光动力学治疗中的实验研究[D].济南:山东大学, 2006.
SONG K.Experimental study of photosensitizer—nanoparticle carrier system in the photodynamic treatment of ovarian cancer [D].Jinan:Shandong University, 2006.
[12] 徐芳. 核黄素光敏化生成活性氧的机制及其应用研究[D].合肥:中国科学技术大学, 2012.
XU F.Mechanism and application of riboflavin photochemical generation of reactive oxygen Species [D].Hefei:University of Science and Technology of China, 2012.
[13] SHARMAN W M, ALLEN C M, VAN L J E.Photodynamic therapeutics:Basic principles and clinical applications[J].Drug Discovery Today, 1999, 4(11):507-517.
[14] 史澍睿, 王悦, 万国运, 等.光动力疗法的抗肿瘤机制及光敏剂的研究进展[J].国际生物医学工程杂志, 2016, 39(5):303-308.
SHI S R, WANG Y, WAN G Y, et al.Research progress on the anti-tumor mechanism and photosensitizer of photodynamic therapy [J].International Journal of Biomedical Engineering, 2016, 39(5):303-308.
[15] 张凤玲. 分子靶向抗癌光敏剂的合成及光动力活性研究[D].福州:福州大学, 2014.
ZHANG F L.Synthesis and photodynamic activity of molecular targeted anti-cancer photosensitizers [D].Fuzhou:Fuzhou University, 2014.
[16] 李廷慧, 顾瑛, 邱海霞, 等.光敏剂的临床应用及研究进展[J].中国激光医学杂志, 2013, 22(5):283-288.
LI T H, GU Y, QIU H X, et al.Clinical application and research progress of photosensitizers [J].Chinese Journal of Laser Medicine, 2013, 22(5):283-288.
[17] 韩晓博, 郑英虹, 杨力明.光敏剂在光动力治疗中的研究进展[J].上海大学学报(自然科学版), 2017, 23(2):169-178.
HAN X B, ZHENG Y H, YANG L M.Research progress of photosensitizer in photodynamic therapy [J].Journal of Shanghai University (Natural Sciences), 2017, 23(2):169-178.
[18] SEIDI D M, MEREDDY R, NETZEL M E, et al.An insight into curcumin-based photosensitization as a promising and green food preservation technology[J].Comprehensive Reviews in Food Science and Food Safety, 2020, 19(4):1 727-1 759.
[19] PANG X, LI D, ZHU J, et al.Beyond antibiotics:Photo/sonodynamic approaches for bacterial theranostics[J].Nano-micro letters, 2020, 12(1):1-23.
[20] MACLEAN M, MACGREGOR S J, ANDERSON J G, et al.Inactivation of bacterial pathogens following exposure to light from a 405-nanometer light-emitting diode array[J].Applied and Environmental Microbiology, 2009, 75(7): 1 932-1 937.
[21] NITZAN Y, SALMON D M, SHPOREN E, et al.ALA induced photodynamic effects on Gram positive and negative bacteria[J].Photochemical and Photobiological Sciences, 2004,3: 430-435.
[22] GUFFEY J S, WILBORN J.In vitro bactericidal effects of 405-nm and 470-nm blue light[J].Photomedicine and Laser Surgery, 2006, 24(6): 684-688.
[23] GHATE V S, ZHOU W, YUK H.Perspectives and trends in the application of photodynamic inactivation for microbiological food safety[J].Comprehensive Reviews in Food Science and Food Safety, 2019, 18(2):402-424.
[24] GHATE V, KUMAR A, ZHOU W B, et al.Effect of organic acids on the photodynamic inactivation of selected foodborne pathogens using 461 nm LEDs[J].Food control, 2015, 57:333-340.
[25] GHATE V, LEONG A L, KUMAR A, et al.Enhancing the antibacterial effect of 461 and 521 nm light emitting diodes on selected foodborne pathogens in trypticase soy broth by acidic and alkaline pH conditions[J].Food Microbiology, 2015, 48:49-57.
[26] DE OLIVEIRA E F, TIKEKAR R, NITIN N.Combination of aerosolized curcumin and UV-A light for the inactivation of bacteria on fresh produce surfaces[J].Food Research International, 2018, 114:133-139.
[27] GLUECK M, SCHAMBERGER B, ECKL P, et al.New horizons in microbiological food safety:Photodynamic decontamination based on a curcumin derivative[J].Photochemical & photobiological sciences, 2017, 16(12):1 784-1 791.
[28] 江天宝. 脉冲强光杀菌技术及其在食品中应用的研究[D].福州:福建农林大学, 2007.
JIANG T B.Research on pulse strong light sterilization technology and its application in food [D].Fuzhou:Fujian Agriculture and Forestry University, 2007.
[29] 刘玉莲. 臭氧气体处理对馒头的保鲜效果研究[D].郑州:河南农业大学, 2018.
LIU Y L.Study on the preservation effect of ozone gas treatment on steamed bread [D].Zhengzhou:Henan Agricultural University, 2018.
[30] 徐斐燕. 鲜切西兰花的保鲜技术研究[D].杭州:浙江大学, 2006.
XU F Y.Study on fresh-cut broccoli preservation technology [D].Hangzhou:Zhejiang University, 2006.
[31] 王凤清, 葛东文, 王东升, 等.二氧化氯杀菌技术在岔北注水站的应用[J].油田化学, 2006, 23(3):231-234.
WANG F Q, GE D W, WANG D S, et al.Application of chlorine dioxide sterilization technology in Cha-Bei water injection station [J].Oilfield Chemistry, 2006, 23(3):231-234.
[32] 曹斌斌, 武娟, 许川山, 等.姜黄素介导的光动力冷杀菌方法对牡蛎杀菌的效果研究[J].食品科学, 2016, 37(5):46-49.
CAO B B, WU J, XU C S, et al.Study on the effect of curcumin mediated photodynamic cold sterilization on the sterilization of oyster [J].Food Science, 2016, 37(5):46-49.
[33] 中华人民共和国国家卫生和计划生育委员会.GB2760—2016 食品安全国家标准 食品添加剂使用标准[S].北京:中国标准出版社, 2016.
National Health and Family Planning Commission of the People's Republic of China.GB2760—2016 National Standard for Food Safety standard for the use of food additives [S].Beijing:China Standard Press, 2016.
[34] SHEN L, JI H F.Theoretical study on physicochemical properties of curcumin[J].Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy, 2007, 67(3-4):619-623.
[35] PRIYADARSINI K I.Photophysics, photochemistry and photobiology of curcumin:Studies from organic solutions, bio-mimetics and living cells[J].Journal of Photochemistry and Photobiology C:Photochemistry Reviews, 2009, 10(2):81-95.
[36] 武娟. 生鲜牡蛎中大肠杆菌和诺如病毒的检测及光动力非热力杀菌相关研究[D].青岛:中国海洋大学, 2015.
WU J.Detection of Escherichia coli and Norovirus in fresh oysters and study on photodynamic non-thermal sterilization [D].Qingdao:Ocean University of China, 2015.
[37] 钟思青, 储博钊.聚乙烯吡咯烷酮单体的合成工艺进展及其应用[J].化学世界, 2020, 61(2):77-82.
ZHONG S Q, CHU B Z.Progress of synthesis of polyvinylpyrrolidone monomer and its application [J].Chemistry World, 2020, 61(2):77-82.
[38] 郭智琼. 聚乙烯吡咯烷酮PVP K12在大鼠体内的药代动力学研究[D].长春:吉林大学, 2020.
GUO Z Q.Pharmacokinetics of polyvinylpyrrolidone PVP K12 in rats [D].Changchun:Jilin University, 2020.
[39] 马婷芳, 史铁钧.聚乙烯吡咯烷酮的性能、合成及应用[J].应用化工, 2002(3):16-19.
MA T F, SHI T J.Performance, synthesis and application of polyvinylpyrrolidone [J].Applied Chemical Engineering, 2002(3):16-19.
[40] WINTER S, TORTIK N, KUBIN A, et al.Back to the roots:Photodynamic inactivation of bacteria based on water-soluble curcumin bound to polyvinylpyrrolidone as a photosensitizer[J].Photochem Photobiol Science, 2013, 12(10):1 795-802.
[41] 林以琳, 邱建清, 李世洋, 等.核黄素介导的光动力技术的研究进展[J].食品工业科技, 2020, 41(6):332-337.
LIN Y L, QIU J Q, LI S Y, et al.Research progress of riboflavin-mediated photodynamic technology [J].Science and Technology of Food Industry, 2020, 41(6):332-337.
[42] CARDOSO D R, LIBARDI S H, SKIBSTED L H.Riboflavin as a photosensitizer.Effects on human health and food quality[J].Food & Function, 2012, 3(5):452-487.
[43] BANERJEE S, GHOSH D, VISHAKHA K, et al.Photodynamic antimicrobial chemotherapy (PACT) using riboflavin inhibits the mono and dual species biofilm produced by antibiotic resistant Staphylococcus aureus and Escherichia coli[J].Photodiagnosis and Photodynamic Therapy, 2020, 32:102002.
[44] KHAN S, P M R, RIZVI A, et al.ROS mediated antibacterial activity of photoilluminated riboflavin:A photodynamic mechanism against nosocomial infections[J].Toxicology Reports, 2019, 6:136-142.
[45] 李江婷. 叶绿素铜钠盐溶液在可见光范围内的光谱特性研究[D].新乡:河南师范大学, 2017.
LI J T.Study on the spectral characteristics of copper sodium chlorophyllin solution in visible light [D].Xinxiang:Henan Normal University, 2017.
[46] 付天齐, 王向伟, 胡江华, 等.叶绿素及其Cu、Zn衍生物的伪装性能研究[J].光电技术应用, 2015, 30(2):33-36.
FU T Q, WANG X W, HU J H, et al.Study on the camouflage performance of chlorophyll and its Cu and Zn derivatives [J].Photoelectric Technology Applications, 2015, 30(2):33-36.
[47] 易静雯. 金丝桃素光动力学效应诱导RINm5F胰岛细胞瘤细胞凋亡及其机制研究[D].长春:东北师范大学, 2015.
YI J W.Photodynamic effect of hypericin induces apoptosis of RINm5F islet cell tumor cells and its mechanism [D].Changchun:Northeast Normal University, 2015.
[48] 李泽波. 金丝桃素及其衍生物高效合成工艺的研究[D].杨凌:西北农林科技大学, 2014.
LI Z B.Study on the efficient synthesis technology of hypericin and its derivatives [D].Yangling:Northwest A&F University, 2014.
[49] KAIRYTE K, LAPINSKAS S, GUDELIS V, et al.Effective inactivation of food pathogens Listeria monocytogenes and Salmonella enterica by combined treatment of hypericin-based photosensitization and high power pulsed light[J].Journal of Applied Microbiology, 2012, 112(6):1 144-1 151.
[50] LUKSIENE Z.Photodynamic therapy:Mechanism of action and ways to improve the efficiency of treatment[J].Medicina (Kaunas, Lithuania), 2003, 39(12):1 137-1 150.
Outlines

/