To explore the possible effect of probiotics and prebiotics on obesity, Lactobacillus plantarum F3-2 and mannooligosaccharides (MOS) to intervene in obese mice. The critical genes of lipid metabolism in adipose tissue and the levels of short-chain fatty acids (SCFAs) in mouse feces were analyzed. The results showed that L. plantarum F3-2 combined with MOS could effectively reduce the body weight of mice, the weight of adipose tissue, the size of adipocytes and the content of TG in serum compared with MOS alone. The levels of SCFAs, especially butyric acid, in mouse feces effectively increased. The inhibitory effect of MOS on critical genes of lipid metabolism in adipose tissue, including peroxisome proliferator-activated receptor-γ (PPARγ) and CCAAT/enhancer binding protein-α(C/EBPα), were enhanced. L. plantarum F3-2 and MOS are expected to act as symbiotic to intervene in dietary structure and improve obesity.
ZHAO Maozhen
,
LIANG Xi
,
ZHANG Zhe
,
LYU Youyou
,
WANG Yin
,
LIU Tongjie
,
YI Huaxi
,
GONG Pimin
,
ZHANG Lanwei
. Lactobacillus plantarum F3-2 and mannooligosaccharides alleviated the obesity of mice through up-regulating SCFAs and inhibiting PPARγ[J]. Food and Fermentation Industries, 2021
, 47(23)
: 78
-82
.
DOI: 10.13995/j.cnki.11-1802/ts.027495
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