Advances in encapsulation of lipophilic marine bioactive substances in emulsion delivery systems

  • LI Jinzhen ,
  • ZHENG Huina ,
  • REN Dingding ,
  • YANG Wen ,
  • CAO Wenhong ,
  • LIN Haisheng ,
  • QIN Xiaoming ,
  • ZHANG Chaohua
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  • 1(College of Food Science and Technology,Guangdong Ocean University,Zhanjiang 524088,China)
    2(Shenzhen Institute of Guangdong Ocean University,Shenzhen 518108,China)
    3(National Research and Development Branch Center for Shellfish Processing (Zhanjiang),Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety,Guangdong Province Engineering Laboratory for Marine Biological Products,Zhanjiang 524088,China)
    4(Collaborative Innovation Center of Seafood Deep Processing,Dalian Polytechnic University,Dalian 116034,China)

Received date: 2021-07-08

  Revised date: 2021-07-29

  Online published: 2022-03-04

Abstract

Despite their many potentially beneficial biological functions,such as enhancing immunity,relieving fatigue,anti-oxidation,improving growth,the bioavailability of lipophilic marine bioactive substances is reduced because of their unfavorable solubility,easy degradation,and high loss rate in gastrointestinal tract.As a carrier of lipophilic marine bioactive substances,emulsion delivery systems can effectively improve its physical and chemical instability,and thus further enhance its bioavailability.This review highlights the types and preparation methods of emulsion delivery systems.In particular,it highlights advances in the construction and characteristics of emulsion systems of several main lipophilic marine bioactive substances.Finally,in view of the problems existing in the current research,this review puts forward some suggestions on the research direction of lipophilic marine bioactive substances emulsion delivery systems in the future.

Cite this article

LI Jinzhen , ZHENG Huina , REN Dingding , YANG Wen , CAO Wenhong , LIN Haisheng , QIN Xiaoming , ZHANG Chaohua . Advances in encapsulation of lipophilic marine bioactive substances in emulsion delivery systems[J]. Food and Fermentation Industries, 2022 , 48(3) : 317 -324 . DOI: 10.13995/j.cnki.11-1802/ts.028530

References

[1] ŠIMAT V,ELABED N,KULAWIK P,et al.Recent advances in marine-based nutraceuticals and their health benefits[J].Marine Drugs,2020,18(12):627.
[2] HOSSEINI S F,REZAEI M,MCCLEMENTS D J.Bioactive functional ingredients from aquatic origin:A review of recent progress in marine-derived nutraceuticals[J].Critical Reviews in Food Science and Nutrition,2020(11):1-28.
[3] ZHAO D,KIM S M,PAN C H,et al.Effects of heating,aerial exposure and illumination on stability of fucoxanthin in canola oil[J].Food Chemistry,2014,145:505-513.
[4] MCCLEMENTS D J,LI Y.Structured emulsion-based delivery systems:Controlling the digestion and release of lipophilic food components[J].Advances in Colloid and Interface Science,2010,159(2):213-228.
[5] YAO M F,LI Z Z,JULIAN MCCLEMENTS D,et al.Design of nanoemulsion-based delivery systems to enhance intestinal lymphatic transport of lipophilic food bioactives:Influence of oil type[J].Food Chemistry,2020,317:126229.
[6] ZHAO T,YAN X J,SUN L J,et al.Research progress on extraction,biological activities and delivery systems of natural astaxanthin[J].Trends in Food Science & Technology,2019,91:354-361.
[7] GALASSO C,OREFICE I,PELLONE P,et al.On the neuroprotective role of astaxanthin:new perspectives?[J].Marine Drugs,2018,16(8):247.
[8] DAVINELLI S,NIELSEN M E,SCAPAGNINI G.Astaxanthin in skin health,repair,and disease:A comprehensive review[J].Nutrients,2018,10(4):E522.
[9] ZHANG T T,XU J,WANG Y M,et al.Health benefits of dietary marine DHA/EPA-enriched glycerophospholipids[J].Progress in Lipid Research,2019,75:100997.
[10] NEWELL M,MAZURAK V,POSTOVIT L M,et al.N-3 long-chain polyunsaturated fatty acids,eicosapentaenoic and docosahexaenoic acid,and the role of supplementation during cancer treatment:a scoping review of current clinical evidence[J].Cancers,2021,13(6):1206.
[11] GHASEMI FARD S,WANG F L,SINCLAIR A J,et al.How does high DHA fish oil affect health? A systematic review of evidence[J].Critical Reviews in Food Science and Nutrition,2019,59(11):1 684-1 727.
[12] ZHAO C,YANG C F,LIU B,et al.Bioactive compounds from marine macroalgae and their hypoglycemic benefits[J].Trends in Food Science & Technology,2018,72:1-12.
[13] LIU M J,LI W W,CHEN Y,et al.Fucoxanthin:A promising compound for human inflammation-related diseases[J].Life Sciences,2020,255:117850.
[14] MARIA A G,GRAZIANO R,NICOLANTONIO D.Carotenoids:potential allies of cardiovascular health?[J].Food & Nutrition Research,2015,59(1):26762.
[15] SARKAR A,MACKIE A R.Engineering oral delivery of hydrophobic bioactives in real-world scenarios[J].Current Opinion in Colloid & Interface Science,2020,48:40-52.
[16] DICKINSON E.Food emulsions and foams:Stabilization by particles[J].Current Opinion in Colloid & Interface Science,2010,15(1-2):40-49.
[17] GUPTA A,ERAL H B,HATTON T A,et al.Nanoemulsions:Formation,properties and applications[J].Soft Matter,2016,12(11):2 826-2 841.
[18] MCCLEMENTS D J.Food Emulsions:Principles,Practices,and Techniques,Third Edition[M].CRC Press,2015.
[19] XIAO J,LI Y Q,HUANG Q R.Recent advances on food-grade particles stabilized Pickering emulsions:Fabrication,characterization and research trends[J].Trends in Food Science & Technology,2016,55:48-60.
[20] ROOS Y H,LIVNEY Y D.Engineering Foods for Bioactives Stability and Delivery[M].New York,NY:Springer,2017.
[21] SHEN X,FANG T Q,ZHENG J,et al.Physicochemical properties and cellular uptake of astaxanthin-loaded emulsions[J].Molecules,2019,24(4):727.
[22] CHOI S J,MCCLEMENTS D J.Nanoemulsions as delivery systems for lipophilic nutraceuticals:Strategies for improving their formulation,stability,functionality and bioavailability[J].Food Science and Biotechnology,2020,29(2):149-168.
[23] BUSH L,STEVENSON L,LANE K E.The oxidative stability of Omega-3 oil-in-water nanoemulsion systems suitable for functional food enrichment:A systematic review of the literature[J].Critical Reviews in Food Science and Nutrition,2019,59(7):1 154-1 168.
[24] 陈帅,高彦祥.天然防腐剂肉桂醛传递载体的构建与应用研究进展[J].中国食品添加剂,2018,19(10):189-195.
CHEN S,GAO Y X.Advances on natural preservative cinnamaldehyde delivery system[J].China Food Additives,2018,19(10):189-195.
[25] 夏天航,魏子淏,马磊,等.负载虾青素的油凝胶纳米乳液的构建及体外消化研究[J].食品与发酵工业,2021,47(9):1-7.
XIA T H,WEI Z H,MA L,et al.The development and its digestion study of astaxanthin-loaded oleogel-based nanoemulsions in vitro[J].Food and Fermentation Industries,2021,47(9):1-7.
[26] 陈雨露,孙婉秋,高彦祥,等.食品运载体系提高酚类物质生物利用度的研究进展[J].食品科学,2020,41(5):323-330.
CHEN Y L,SUN W Q,GAO Y X,et al.Recent progress in food delivery systems for improving bioavailability of phenolic compounds[J].Food Science,2020,41(5):323-330.
[27] ACEVEDO-FANI A,SILVA H D,SOLIVA-FORTUNY R,et al.Formation,stability and antioxidant activity of food-grade multilayer emulsions containing resveratrol[J].Food Hydrocolloids,2017,71:207-215.
[28] LIU C Z,TAN Y B,XU Y,et al.Formation,characterization,and application of chitosan/pectin-stabilized multilayer emulsions as astaxanthin delivery systems[J].International Journal of Biological Macromolecules,2019,140:985-997.
[29] FIORAMONTI S A,MARTINEZ M J,PILOSOF A M R,et al.Multilayer emulsions as a strategy for linseed oil microencapsulation:effect of ph and alginate concentration[J].Food Hydrocolloids,2015,43:8-17.
[30] 徐文华,张佳,王梓涵,等.双重乳液的制备及应用研究进展[J].食品与机械,2020,36(9):1-11.
XU W H,ZHANG J,WANG Z H,et al.Progress in preparation and application of double emulsion[J].Food & Machinery,2020,36(9):1-11.
[31] EVANS M,RATCLIFFE I,WILLIAMS P A.Emulsion stabilisation using polysaccharide-protein complexes[J].Current Opinion in Colloid & Interface Science,2013,18(4):272-282.
[32] TAVERNIER I,WIJAYA W,VAN DER MEEREN P,et al.Food-grade particles for emulsion stabilization[J].Trends in Food Science & Technology,2016,50:159-174.
[33] CHEN L J,AO F,GE X M,et al.Food-grade pickering emulsions:preparation,stabilization and applications[J].Molecules,2020,25(14):3202.
[34] NIROULA A,GAMOT T D,OOI C W,et al.Biomolecule-based pickering food emulsions:Intrinsic components of food matrix,recent trends and prospects[J].Food Hydrocolloids,2021,112:106303.
[35] 王文莉,柴向华,范宇婷,等.基于玉米醇溶蛋白纳米颗粒稳定的Pickering乳液研究进展[J].食品与发酵工业,2021,47(18):301-307.
WANG W L,CHAI X H,FAN Y T,et al.Advances of Pickering emulsion stabilized by zein-based complex nanoparticles[J].Food and Fermentation Industries,2021,47(18):301-307.
[36] WEI Z H,CHENG Y J,ZHU J Y,et al.Genipin-crosslinked ovotransferrin particle-stabilized Pickering emulsions as delivery vehicles for hesperidin[J].Food Hydrocolloids,2019,94:561-573.
[37] 刘建国,李虎,张孟洁,等.红球藻虾青素与炎症反应和肺部疾病的研究进展[J].生物学杂志,2021,38(2):8-12.
LIU J G,LI H,ZHANG M J,et al.Research progress of the astaxanthin from Haematococcus pluvialis in inflammation and lung diseases[J].Journal of Biology,2021,38(2):8-12.
[38] AMBATI R R,PHANG S M,RAVI S,et al.Astaxanthin:Sources,extraction,stability,biological activities and its commercial applications:A review[J].Marine Drugs,2014,12(1):128-152.
[39] FARAONE I,SINISGALLI C,OSTUNI A,et al.Astaxanthin anticancer effects are mediated through multiple molecular mechanisms:A systematic review[J].Pharmacological Research,2020,155:104689.
[40] CHEN Z,LI W H,SHI L W,et al.Kidney-targeted astaxanthin natural antioxidant nanosystem for diabetic nephropathy therapy[J].European Journal of Pharmaceutics and Biopharmaceutics,2020,156:143-154.
[41] MARTÍNEZ-DELGADO A A,KHANDUAL S,VILLANUEVA-RODRÍGUEZ S J.Chemical stability of astaxanthin integrated into a food matrix:Effects of food processing and methods for preservation[J].Food Chemistry,2017,225:23-30.
[42] KOTAKE-NARA E,NAGAO A.Absorption and metabolism of xanthophylls[J].Marine Drugs,2011,9(6):1 024-1 037.
[43] BOONLAO N,SHRESTHA S,SADIQ M B,et al.Influence of whey protein-xanthan gum stabilized emulsion on stability and in vitro digestibility of encapsulated astaxanthin[J].Journal of Food Engineering,2020,272:109859.
[44] SHANMUGAPRIYA K,KIM H,SARAVANA P S,et al.Astaxanthin-alpha tocopherol nanoemulsion formulation by emulsification methods:Investigation on anticancer,wound healing,and antibacterial effects[J].Colloids and Surfaces B:Biointerfaces,2018,172:170-179.
[45] BURGOS-DÍAZ C,OPAZO-NAVARRETE M,SOTO-AÑUAL M,et al.Food-grade Pickering emulsion as a novel astaxanthin encapsulation system for making powder-based products:Evaluation of astaxanthin stability during processing,storage,and its bioaccessibility[J].Food Research International (Ottawa,Ont.),2020,134:109244.
[46] MOZAFFARI H,DANESHZAD E,LARIJANI B,et al.Dietary intake of fish,n-3 polyunsaturated fatty acids,and risk of inflammatory bowel disease:A systematic review and meta-analysis of observational studies[J].European Journal of Nutrition,2020,59(1):1-17.
[47] MANSON J E,COOK N R,LEE I M,et al.Marine n-3 fatty acids and prevention of cardiovascular disease and cancer[J].The New England Journal of Medicine,2019,380(1):23-32.
[48] INNES J K,CALDER P C.Marine omega-3(n-3) fatty acids for cardiovascular health:An update for 2020[J].International Journal of Molecular Sciences,2020,21(4):1362.
[49] MARTINS B P,BANDARRA N M,FIGUEIREDO-BRAGA M.The role of marine omega-3 in human neurodevelopment,including Autism Spectrum Disorders and Attention-Deficit/Hyperactivity Disorder-a review[J].Critical Reviews in Food Science and Nutrition,2020,60(9):1 431-1 446.
[50] PADIAL-DOMÍNGUEZ M,ESPEJO-CARPIO F J,GARCÍA-MORENO P J,et al.Protein derived emulsifiers with antioxidant activity for stabilization of omega-3 emulsions[J].Food Chemistry,2020,329:127148.
[51] LEE M C,TAN C,ABBASPOURRAD A.Combination of internal structuring and external coating in an oleogel-based delivery system for fish oil stabilization[J].Food Chemistry,2019,277:213-221.
[52] COMUNIAN T A,RAVANFAR R,SELIG M J,et al.Influence of the protein type on the stability of fish oil in water emulsion obtained by glass microfluidic device[J].Food Hydrocolloids,2018,77(1):96-106.
[53] LIU J H,LIU W L,SALT L J,et al.Fish oil emulsions stabilized with caseinate glycated by dextran:Physicochemical stability and gastrointestinal fate[J].Journal of Agricultural and Food Chemistry,2019,67(1):452-462.
[54] SALVIA-TRUJILLO L,DECKER E A,MCCLEMENTS D J.Influence of an anionic polysacchide on the physical and oxidative stability of omega-3 nanoemulsions:Antioxidant effects of alginate[J].Food Hydrocolloids,2016,52:690-698.
[55] AZIZI M,LI Y T,KAUL N,et al.Study of the physicochemical properties of fish oil solid lipid nanoparticle in the presence of palmitic acid and quercetin[J].Journal of Agricultural and Food Chemistry,2019,67(2):671-679.
[56] MIYASHITA K,BEPPU F,HOSOKAWA M,et al.Nutraceutical characteristics of the brown seaweed carotenoid fucoxanthin[J].Archives of Biochemistry and Biophysics,2020,686:108364.
[57] ZHANG Y P,XU W,HUANG X Q,et al.Fucoxanthin ameliorates hyperglycemia,hyperlipidemia and insulin resistance in diabetic mice partially through IRS-1/PI3K/Akt and AMPK pathways[J].Journal of Functional Foods,2018,48:515-524.
[58] MIYASHITA K,HOSOKAWA M.Fucoxanthin in the management of obesity and its related disorders[J].Journal of Functional Foods,2017,36:195-202.
[59] EID S Y,ALTHUBITI M A,ABDALLAH M E,et al.The carotenoid fucoxanthin can sensitize multidrug resistant cancer cells to doxorubicin via induction of apoptosis,inhibition of multidrug resistance proteins and metabolic enzymes[J].Phytomedicine,2020,77:153280.
[60] 李敏兰,弓泽华,盛滟,等.岩藻黄素提取与分析方法研究进展[J].食品研究与开发,2021,42(3):202-206.
LI M L,GONG Z H,SHENG Y,et al.Advances in extraction and analysis methods of fucoxanthin[J].Food Research and Development,2021,42(3):202-206.
[61] WANG C Y,CHEN X,NAKAMURA Y,et al.Fucoxanthin activities motivate its nano/micro-encapsulation for food or nutraceutical application:A review[J].Food & Function,2020,11(11):9 338-9 358.
[62] ZHAO D,YU D,KIM M,et al.Effects of temperature,light,and pH on the stability of fucoxanthin in an oil-in-water emulsion[J].Food Chemistry,2019,291:87-93.
[63] MOK I K,YOON J R,PAN C H,et al.Development,quantification,method validation,and stability study of a novel fucoxanthin-fortified milk[J].Journal of Agricultural and Food Chemistry,2016,64(31):6 196-6 202.
[64] SARAVANA P S,SHANMUGAPRIYA K,GERENIU C R N,et al.Ultrasound-mediated fucoxanthin rich oil nanoemulsions stabilized by κ-carrageenan:Process optimization,bio-accessibility and cytotoxicity[J].Ultrasonics Sonochemistry,2019,55:105-116.
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