Food and Fermentation Industries >

2022 , Vol. 48 >Issue 8: 90 - 97

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.028601

Alleviation effects of soymilk fermented by Lactobacillus plantarum on gut microbiota dysbiosis in rats with polycystic ovary syndrome

  • QI Yajin ,
  • HE Yufeng ,
  • YANG Yuqian ,
  • SHI Liuting ,
  • ZHAN Yu ,
  • LU Jiaxin ,
  • GUO Min ,
  • WANG Huiling ,
  • ZHAO Jianxin ,
  • ZHANG Hao ,
  • WANG Gang ,
  • CHEN Wei
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  • 1(School of Food Science and Technology, Jiangnan University, Wuxi 214122, China)
    2(Suzhou Municipal Hospital, Suzhou Hospital Affiliated to Nanjing Medical University, Gusu College of Nanjing Medical University, Suzhou 215002, China)

Received date: 2021-07-14

  Revised date: 2021-08-18

  Online published: 2022-05-18

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Abstract

It has been found that soymilk fermented by Lactobacillus plantarum CCFM1019, LP4 or LP5 can improve some pathological indicators of polycystic ovary syndrome (PCOS) rat model in previous study. In order to further explore the relationship between the improvement of pathological indicators and the changes in the intestinal environment, the gut microbiota and the level of fecal short-chain fatty acids (SCFAs) were analyzed. In addition, the correlation of the gut microbiota, SCFAs and sex hormone levels in rats were analyzed. The results showed that soymilk fermented by L. plantarum CCFM1019, LP4 or LP5 significantly increased the diversity of gut microbiota in PCOS rats. Compared with the letrozole group, soymilk fermented by three strains of L. plantarum significantly restored the relative abundance of Lactobacillus and Prevotellaceae UCG-001 to normal levels. It was indicated that the relative abundance of Lactobacillus was positively correlated with the level of testosterone (T). The relative abundance of Lachnospira was positively correlated with the estradiol level and negatively correlated with the luteinizing hormone level. The relative abundance of Prevotellaceae UCG-001 and Ruminococcaceae UCG-014 were positively correlated with the gonadotropin-releasing hormone level. However, the effects of L. plantarum fermented soymilk on the level of SCFAs were not significant. In conclusion, soymilk fermented by L. plantarum CCFM1019, LP4 or LP5 significantly affected the diversity and composition of gut microbiota in PCOS rats. And these effects were significantly correlated with sex hormone levels. These results suggest that regulating the gut microbiota may be the potential mechanism of L. plantarum fermented soymilk to alleviate the disorder of hormone levels in PCOS rats.

Key words： Lactobacillus plantarum; fermented soymilk; polycystic ovary syndrome; gut microbiota; sex hormones

Cite this article

QI Yajin , HE Yufeng , YANG Yuqian , SHI Liuting , ZHAN Yu , LU Jiaxin , GUO Min , WANG Huiling , ZHAO Jianxin , ZHANG Hao , WANG Gang , CHEN Wei . Alleviation effects of soymilk fermented by Lactobacillus plantarum on gut microbiota dysbiosis in rats with polycystic ovary syndrome[J]. Food and Fermentation Industries, 2022 , 48(8) : 90 -97 . DOI: 10.13995/j.cnki.11-1802/ts.028601

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