Food and Fermentation Industries >

2022 , Vol. 48 >Issue 8: 150 - 158

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.027795

Preparation of κ-carrageenan/konjac glucomannan/carboxymethyl starch composite film and hollow capsule

  • ZHANG Yang ,
  • ZHANG Qing ,
  • ZHAO Yi ,
  • DENG Liling ,
  • ZHONG Geng
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  • 1(College of Food Science South University, Chongqing 400715, China)
    2(Country Chongqing Institute of Biotechnology Co.Ltd., Chongqing 401121, China)

Received date: 2021-03-22

  Revised date: 2021-05-29

  Online published: 2022-05-18

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Abstract

In this study, the degradable composite film was prepared by using κ-carrageenan, konjac glucomannan and carboxymethyl starch as the film-forming substrate, and the glue (mixing of κ-carrageenan and konjac glucomannan) was mixed with carboxymethyl starch in different mass ratio to compound the film. The mechanical properties, barrier properties and solubility of the composite film with different mass ratio were measured, and the compatibility of the composite films was evaluated by light transmittance, infrared spectroscopy, X-ray diffraction and scanning electron microscopy. On this basis, hollow capsules were prepared with reference to the production process of gelatin capsules, and their dissolution and stability were studied. The results showed that a proper amount of carboxymethyl starch could improve the mechanical properties, barrier properties and solubility of the composite film. When the mass ratio of mixed glue to carboxymethyl starch was 6∶4 and 5∶5, the comprehensive performance of the composite film was good. The results of light transmittance, infrared spectroscopy, X-ray diffraction, etc. showed that the components of the composite film had good compatibility. Two self-made capsules (6∶4 and 5∶5) met the national pharmacopeia standards, and carboxymethyl starch played a key role in capsule disintegration performance. And the higher the ratio of carboxymethyl starch, the shorter the capsule disintegration time. With cimetidine as a model drug, when the dissolution time was 15 minutes, the cumulative dissolution percentages of cimetidine in self-made 6∶4 capsules and 5∶5 capsules reached 87.70% and 89.45%, respectively. Meanwhile, the dissolution time of cimetidine of the self-made capsules was advanced after high-temperature treatment but did not affect the final dissolution amount, and the high temperature stability was better than that of gelatin capsules.

Key words： carboxymethyl starch; konjac glucomannan; composite film; hollow capsule

Cite this article

ZHANG Yang , ZHANG Qing , ZHAO Yi , DENG Liling , ZHONG Geng . Preparation of κ-carrageenan/konjac glucomannan/carboxymethyl starch composite film and hollow capsule[J]. Food and Fermentation Industries, 2022 , 48(8) : 150 -158 . DOI: 10.13995/j.cnki.11-1802/ts.027795

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