Research progress of γ-aminobutyric acid in cereal fermented food

  • YU Dehui ,
  • YANG Yang ,
  • CHEN Fenglian ,
  • FAN Jing ,
  • BIAN Xin ,
  • WANG Bing ,
  • WANG Mengju ,
  • LIU Simiao ,
  • XING Wenjing ,
  • ZHANG Na
Expand
  • (Harbin University of Commerce College of Food Engineering, Harbin 150028, China)

Received date: 2021-08-24

  Revised date: 2021-10-09

  Online published: 2022-06-23

Abstract

γ-Aminobutyric acid (GABA)is a functional component widely existed in animal, plant and microorganism. It has many biological activities such as alleviating anxiety, lowering blood pressure, anti-diabetic, anti-cancer, treatment of epilepsy, asthma, etc. GABA content is generally low in natural cereal, but it can be effectively enriched through microbial fermentation. This paper reviews the mechanism of action, metabolic pathways, synthesis and physiological functions of GABA, and systematically expounds the research status of GABA rich cereal fermented food, so as to provide a theoretical basis for future development of cereal fermented food rich in GABA.

Cite this article

YU Dehui , YANG Yang , CHEN Fenglian , FAN Jing , BIAN Xin , WANG Bing , WANG Mengju , LIU Simiao , XING Wenjing , ZHANG Na . Research progress of γ-aminobutyric acid in cereal fermented food[J]. Food and Fermentation Industries, 2022 , 48(11) : 290 -296 . DOI: 10.13995/j.cnki.11-1802/ts.029113

References

[1] QUILEZ J, DIANA M.Gamma-aminobutyric Acid-enriched Fermented Foods[M].Barcelona:Academic Press, 2016.
[2] ABDELAZEZ A, ABDELMOTAAL H, EVIVIE S E, et al.Screening potential probiotic characteristics of Lactobacillus brevis strains in vitro and intervention effect on type I diabetes in vivo[J].BioMed Research International, 2018, 2018:7356173.
[3] WU Q L, SHAH N P.High γ-aminobutyric acid production from lactic acid bacteria:Emphasis on Lactobacillus brevis as a functional dairy starter[J].Critical Reviews in Food Science and Nutrition, 2017, 57(17):3 661-3 672.
[4] XU N, WEI L, LIU J.Biotechnological advances and perspectives of gamma-aminobutyric acid production[J].World Journal of Microbiology & Biotechnology, 2017, 33(3):64.
[5] BARLA F, KOYANAGI T, TOKUDA N, et al.The γ-aminobutyric acid-producing ability under low pH conditions of lactic acid bacteria isolated from traditional fermented foods of Ishikawa Prefecture, Japan, with a strong ability to produce ACE-inhibitory peptides[J].Biotechnology Reports, 2016, 10:105-110.
[6] LI Y J, CHEN X, SHU G W, et al.Screening of gamma-aminobutyric acid-producing lactic acid bacteria and its application in Monascus-fermented rice production[J].Acta Scientiarum Polonorum.Technologia Alimentaria, 2020, 19(4):387-394.
[7] SARASA S B, MAHENDRAN R, MUTHUSAMY G, et al.A brief review on the non-protein amino acid, gamma-amino butyric acid (GABA):Its production and role in microbes[J].Current Microbiology, 2020, 77(4):534-544.
[8] PIZZARELLI R, CHERUBINI E.Alterations of GABAergic signaling in autism spectrum disorders[J].Neural Plasticity, 2011, 2011:297153.
[9] CUN L G, GHANI M W, YI Z, et al.Different combinations of GABA, BMP7, and Activin A induced the in vitro differentiation of rat pancreatic ductal stem cells into insulin-secreting islet-like cell clusters[J].Life Sciences, 2021, 267:118451.
[10] FRANKLIN I K, WOLLHEIM C B.GABA in the endocrine pancreas:Its putative role as an islet cell paracrine-signalling molecule[J].The Journal of General Physiology, 2004, 123(3):185-190.
[11] BALÁZS R, MACHIYAMA Y, HAMMOND B J, et al.The operation of the gamma-aminobutyrate bypath of the tricarboxylic acid cycle in brain tissue in vitro[J].The Biochemical Journal, 1970, 116(3):445-461.
[12] ROBERTS E, KURIYAMA K.Biochemical-physiology correlations in studies of the γ-aminobutyric acid system[J].Brain Research, 1968, 8(1):1-35.
[14] 孙磊, 王苑, 柏映国, 等.谷氨酸脱羧酶结构及催化机制的研究概述[J].微生物学通报, 2020, 47(7):2 236-2 244.
SUN L, WANG Y, BAI Y G, et al.Structure and catalytic mechanism of glutamate decarboxylase:A review[J].Microbiology China, 2020, 47(7):2 236-2 244.
[15] 朱莉, 宋福平, 张杰, 等.苏云金芽胞杆菌γ-氨基丁酸代谢途径相关功能基因的克隆、表达及同源性分析[J].微生物学通报, 2007, 34(6):1 031-1 036.
ZHU L, SONG F P, ZHANG J, et al.Cloning, expression and phylogenetic analysis of two GABA shunt-related proteins from Bacillus thuringiensis[J].Microbiology, 2007, 34(6):1 031-1 036.
[16] 宁亚维, 马梦戈, 杨正, 等.γ-氨基丁酸的制备方法及其功能食品研究进展[J].食品与发酵工业, 2020, 46(23):238-247.
NING Y W, MA M G, YANG Z, et al.Research progress in the enrichment process and functional foods of γ-aminobutyric acid[J].Food and Fermentation Industries, 2020, 46(23):238-247.
[17] SHERWIN E, SANDHU K V, DINAN T G, et al.May the force be with you:The light and dark sides of the microbiota-gut-brain axis in neuropsychiatry[J].CNS Drugs, 2016, 30(11):1 019-1 041.
[18] RISSMAN R A, MOBLEY W C.Implications for treatment:GABAA receptors in aging, Down syndrome and Alzheimer's disease[J].Journal of Neurochemistry, 2011, 117(4):613-622.
[19] PRAGER E M, BERGSTROM H C, WYNN G H, et al.The basolateral amygdala γ-aminobutyric acidergic system in health and disease[J].Journal of Neuroscience Research, 2016, 94(6):548-567.
[20] MÖHLER H.The GABA system in anxiety and depression and its therapeutic potential[J].Neuropharmacology, 2012, 62(1):42-53.
[21] HE Y J, OUYANG J Y, HU Z Y, et al.Intervention mechanism of repeated oral GABA administration on anxiety-like behaviors induced by emotional stress in rats[J].Psychiatry Research, 2019, 271:649-657.
[22] TUNG Y T, LEE B H, LIU C F, et al.Optimization of culture condition for ACEI and GABA production by lactic acid bacteria[J].Journal of Food Science, 2011, 76(9):M585-M591.
[23] 郜秋艳, 尹杰, 张金玉, 等.茶叶中γ-氨基丁酸的研究进展[J].中国茶叶, 2021, 43(1):10-19.
GAO Q Y, YIN J, ZHANG J Y, et al.Research progress on the γ-aminobutyric acid in tea[J].China Tea, 2021, 43(1):10-19.
[24] BRZOZOWSKA A, BURDAN F, DUMA D, et al.γ-amino butyric acid (GABA) level as an overall survival risk factor in breast cancer[J].Annals of Agricultural and Environmental Medicine:AAEM, 2017, 24(3):435-439.
[25] SHETTY A K, UPADHYA D.GABA-ergic cell therapy for epilepsy:Advances, limitations and challenges[J].Neuroscience & Biobehavioral Reviews, 2016, 62:35-47.
[26] BOONSTRA E, DE KLEIJN R, COLZATO L S, et al.Neurotransmitters as food supplements:The effects of GABA on brain and behavior[J].Frontiers in Psychology, 2015, 6:1520.
[27] YOCUM G T, TURNER D L, DANIELSSON J, et al.GABA A receptor α 4-subunit knockout enhances lung inflammation and airway reactivity in a murine asthma model[J].American Journal of Physiology.Lung Cellular and Molecular Physiology, 2017, 313(2):L406-L415.
[28] HINTON T, JELINEK H F, VIENGKHOU V, et al.Effect of GABA-fortified oolong tea on reducing stress in a university student cohort[J].Frontiers in Nutrition, 2019, 6:27.
[29] CHUNG S I, JIN X, KANG M Y.Enhancement of glucose and bone metabolism in ovariectomized rats fed with germinated pigmented rice with giant embryo (Oryza sativa L.cv.Keunnunjami)[J].Food & Nutrition Research, 2019, 63.
[30] POULIOT-MATHIEU K, GARDNER-FORTIER C, LEMIEUX S, et al.Effect of cheese containing gamma-aminobutyric acid-producing lactic acid bacteria on blood pressure in men[J].PharmaNutrition, 2013, 1(4):141-148.
[31] AOKI H, UDA I, TAGAMI K, et al.The production of a new tempeh-like fermented soybean containing a high level of γ-aminobutyric acid by anaerobic incubation with Rhizopus[J].Bioscience, Biotechnology, and Biochemistry, 2003, 67(5):1 018-1 023.
[32] TAMAYA K, MATSUI T, TOSHIMA A, et al.Suppression of blood glucose level by a new fermented tea obtained by tea-rolling processing of loquat (Eriobotrya japonica) and green tea leaves in disaccharide-loaded Sprague-Dawley rats[J].Journal of the Science of Food and Agriculture, 2010, 90(5):779-783.
[33] BAGHERI S, HEYDARI A, ALINAGHIPOUR A, et al.Effect of probiotic supplementation on seizure activity and cognitive performance in PTZ-induced chemical kindling[J].Epilepsy & Behavior, 2019, 95:43-50.
[34] 杨帆. 微生物转化法产γ-氨基丁酸[D].无锡:江南大学, 2008.
YANG F.γ-aminobutyric acid produced by microbial transformation[D].Wuxi:Jiangnan University, 2008.
[35] ZHANG Q, XIANG J, ZHANG L Z, et al.Optimizing soaking and germination conditions to improve gamma-aminobutyric acid content in japonica and indica germinated brown rice[J].Journal of Functional Foods, 2014, 10:283-291.
[36] ZUSHI K, MATSUZOE N.Salt stress-enhanced γ-aminobutyric acid (gaba) in tomato fruit[J].Acta Horticulturae, 2007(761):431-435.
[37] SAIKUSA T, CAI Y M, HIGUCHI K, et al.Selection of lactic acid bacterium Lactococcus lactis RO50 which produced high γ-aminobutyric acid (GABA) to rice flour fermentation and method for producing of GABA-enriched rice flour using RO50[J].Nippon Shokuhin Kagaku Kogaku Kaishi, 2016, 63(8):339-346.
[38] ZHANG Q, SUN Q, TAN X, et al.Characterization of γ-aminobutyric acid (GABA)-producing Saccharomyces cerevisiae and coculture with Lactobacillus plantarum for mulberry beverage brewing[J].Journal of Bioscience and Bioengineering, 2020, 129(4):447-453.
[39] 林杨, 唐琦勇, 楚敏, 等.γ-氨基丁酸的功能、生产及食品应用研究进展[J].中国调味品, 2021, 46(6):173-179.
LIN Y, TANG Q Y, CHU M, et al.Research progress on function, production and food application of γ-aminobutyric acid[J].China Condiment, 2021, 46(6):173-179.
[40] WATANABE Y, HAYAKAWA K, UENO H.Effects of co-culturing LAB on GABA production[J].Journal of Biological Macromolecules, 2011, 11(1):3-13.
[41] PERPETUINI G, TITTARELLI F, BATTISTELLI N, et al.γ-aminobutyric acid production by Kluyveromyces marxianus strains[J].Journal of Applied Microbiology, 2020, 129(6):1 609-1 619.
[42] NG'ONG'OLA-MANANI T A, ØSTLIE H M, MWANGWELA A M, et al.Metabolite changes during natural and lactic acid bacteria fermentations in pastes of soybeans and soybean-maize blends[J].Food Science & Nutrition, 2014, 2(6):768-785.
[43] 黄敏欣. 广东客家黄酒产γ-氨基丁酸的影响因素及代谢调控研究[D].广州:仲恺农业工程学院, 2016.
HUANG M X.Factors affecting γ-aminobutyric acid and its metabolic control in Guangdong Hakka rice wine[D].Guangzhou:Zhongkai University of Agriculture and Engineering, 2016.
[44] KOBAYASI A, PHROMRAKSA P, KATOH M, et al.Improvement of fermented rice noodles in thailand and their characteristics[J].Journal of Home Economics, 2007, 58(8):463-470.
[45] LI Y J, CHEN X, SHU G W, et al.Screening of gamma-aminobutyric acid-producing lactic acid bacteria and its application in Monascus-fermented rice production[J].Acta Scientiarum Polonorum Technologia Alimentaria, 2020, 19(4):387-394.
[46] DIANA M, RAFECAS M, QUILEZ J.Sourdough bread enriched with γ-aminobutyric acid(GABA).A comparison of free amino acid, biogenic amine and acrylamide content in GABA-enriched sourdough and commercial breads[J].Journal of Cereal Sciences, 2014, 60(3):639-644.
[47] RIZZELLO C G, CASSONE A, DI CAGNO R, et al.Synthesis of angiotensin I-converting enzyme (ACE)-inhibitory peptides and γ-aminobutyric acid (GABA) during sourdough fermentation by selected lactic acid bacteria[J].Journal of Agricultural and Food Chemistry, 2008, 56(16):6 936-6 943.
[48] CODA R, RIZZELLO C G, GOBBETTI M.Use of sourdough fermentation and pseudo-cereals and leguminous flours for the making of a functional bread enriched of γ-aminobutyric acid (GABA)[J].International Journal of Food Microbiology, 2010, 137(2-3):236-245.
[49] 姚世聪, 赵丹, 路锶.不同发酵剂对小米营养成分及γ-氨基丁酸含量的影响[J].食品工业科技, 2012, 33(19):165-167;172.
YAO S C, ZHAO D, LU S.Effect of different filamentous fungi fermentation on nutritional components and γ-Aminobutyric Acid content of millet[J].Science and Technology of Food Industry, 2012, 33(19):165-167;172.
[50] CHEN C X, CHEN F S.Study on the conditions to brew rice vinegar with high content of γ-amino butyric acid by response surface methodology[J].Food and Bioproducts Processing, 2009, 87(4):334-340.
Outlines

/