[1] UNLU A, NAYIR E, KIRCA O, et al.Ganoderma lucidum (reishi mushroom) and cancer[J].Journal of B.U.ON.:Official Journal of the Balkan Union of Oncology, 2016, 21(4):792-798.
[2] CHEN B Z, KE B R, YE L Y, et al.Isolation and varietal characterization of Ganoderma resinaceum from areas of Ganoderma lucidum production in China[J].Scientia Horticulturae, 2017, 224:109-114.
[3] YE L Y, LIU S R, XIE F, et al.Enhanced production of polysaccharides and triterpenoids in Ganoderma lucidum fruit bodies on induction with signal transduction during the fruiting stage[J].PLoS One, 2018, 13(4):e0196287.
[4] ZHOU X W, SU K Q, ZHANG Y M.Applied modern biotechnology for cultivation of Ganoderma and development of their products[J].Applied Microbiology and Biotechnology, 2012, 93(3):941-963.
[5] YANG Y L, ZHANG H N, ZUO J H, et al.Advances in research on the active constituents and physiological effects of Ganoderma lucidum[J].Biomedical Dermatology, 2019, 3:6.
[6] KOCH C, MÜLLER S.Personalized microbiome dynamics-Cytometric fingerprints for routine diagnostics[J].Molecular Aspects of Medicine, 2018, 59:123-134.
[7] CAO Y, LIU H L, QIN N B, et al.Impact of food additives on the composition and function of gut microbiota:A review[J].Trends in Food Science & Technology, 2020, 99:295-310.
[8] JUNG C, HUGOT J P, BARREAU F.Peyer's patches:The immune sensors of the intestine[J].International Journal of Inflammation, 2010, 2 010:823710.
[9] VELMURUGAN G, DINAKARAN V, RAJENDHRAN J, et al.Blood microbiota and circulating microbial metabolites in diabetes and cardiovascular disease[J].Trends in Endocrinology & Metabolism, 2020, 31(11):835-847.
[10] GHOLIZADEH P, MAHALLEI M, PORMOHAMMAD A, et al.Microbial balance in the intestinal microbiota and its association with diabetes, obesity and allergic disease[J].Microbial Pathogenesis, 2019, 127:48-55.
[11] ZHONG L D, YAN P J, LAM W C, et al.Coriolus versicolor and Ganoderma lucidum related natural products as an adjunct therapy for cancers:A systematic review and meta-analysis of randomized controlled trials[J].Frontiers in Pharmacology, 2019, 10:703.
[12] HWANG I W, KIM B M, KIM Y C, et al.Improvement in β-glucan extraction from Ganoderma lucidum with high-pressure steaming and enzymatic pre-treatment[J].Applied Biological Chemistry, 2018, 61(2):235-242.
[13] 陈伟, 马飞, 张琳, 等.灵芝有效成分提取及药理活性研究进展[J].安徽农业科学, 2016, 44(8):147-149;202.
CHEN W, MA F, ZHANG L, et al.Progress on the studies of extraction and pharmacological activities of bioactive compounds from Ganoderma lucidum[J].Journal of Anhui Agricultural Sciences, 2016, 44(8):147-149:202.
[14] SHIAO M S, LEE K R, LIN L J, et al.Natural products and biological activities of the Chinese medicinal fungus Ganoderma lucidum[J].ChemInform, 2010, 3(3):172-180.
[15] 李艳辉, 王琦.真菌多糖的生物活性与构效关系研究评价[J].吉林农业大学学报, 2002,24(2):70-74.
LI Y H, WANG Q.A review of the studies on the relationship between activity and structure of polysaccharides from fungi[J].Journal of Jilin Agricultural University, 2002, 24(2):70-74.
[16] CHEN R Y, YU D Q.Progress of studies on the chemical constituents of Ganoderma triterpene[J].Acta ph-armaceutica Sinica,1990, 25(12):940-953.
[17] 王涛. 灵芝三萜的提纯及其对前列腺癌细胞生长的影响[D].广州:南方医科大学, 2016.
WANG T.The extraction, purification of Ganoderma lucidum triterpenoids and its effect on cell proliferation and apoptosis in prostate cancer[D].Guangzhou:Southern Medical University, 2016.
[18] FATMAWATI S, SHIMIZU K, KONDO R.Structure-activity relationships of Ganoderma acids from Ganoderma lucidum as aldose reductase inhibitors[J].Bioorganic & Medicinal Chemistry Letters, 2011, 21(24):7 295-7 297.
[19] 姚松君. 灵芝三萜的超声波提取工艺及其指纹图谱检测方法的研究[D].广州:华南理工大学,2010.
YAO S J.Study on technology of ultrasonic extraction of triterpenoids from Ganoderma lucidum and its fingerprint method[D].Guangzhou:South China University of Technology,2010.
[20] 高宇杰, 赵立艳, 安辛欣, 等.超临界CO2萃取灵芝孢子油及其挥发性成分分析[J].食品科学, 2014, 35(2):41-46.
GAO Y J, ZHAO L Y, AN X X, et al.Supercritical CO2 extraction of oil from Ganoderma lucidum spore and analysis of its volatile compounds[J].Food Science, 2014, 35(2):41-46.
[21] 张双双. 四种灵芝科真菌和硬柄小皮伞的化学成分及生物活性研究[D].南京:南京农业大学, 2015.
ZHANG S S.Chemical consitituents and bioacitivities of Marasmius oreades and four fungi in Ganodermataceae[D].Nanjing:Nanjing Agricultural University, 2015.
[22] 李向敏. 皱盖假芝和灵芝孢子中甾醇类化合物抗肿瘤作用机制研究[D].广州:华南理工大学,2015.
LI X M.Anti-tumor effect and mechanisms of sterols from Amauroderma rude and Ganoderma lucidum spore[D].Guangzhou:South China University of Technology,2015.
[23] 贾硕. 黑灵芝甾醇组分制备、抑菌活性及其体外抗氧化活性研究[D].南昌:南昌大学, 2019.
JIA S.Preparation, antibacterial activity and antioxidant activity of sterol compound from Ganoderma atrum[D].Nanchang:Nanchang University, 2019.
[24] 姜芳燕, 马军, 陈永敢, 等.灵芝活性成分的研究进展[J].黑龙江农业科学, 2014(8):137-142.
JIANG F Y, MA J, CHEN Y G, et al.Research progress on active ingredients of Ganoderma sp.[J].Heilongjiang Agricultural Sciences, 2014(8):137-142.
[25] 于华峥, 刘艳芳, 周帅, 等.灵芝子实体、菌丝体和孢子粉化学成分的比较[J].食品与生物技术学报, 2016, 35(8):823-827.
YU H Z, LIU Y F, ZHOU S, et al.Difference of chemical components in fruiting body, mycelium and spore powder of Ganoderma Lingzhi[J].Journal of Food Science and Biotechnology, 2016, 35(8):823-827.
[26] KINO K, YAMASHITA A, YAMAOKA K, et al.Isolation and characterization of a new immunomodulatory protein, Ling Zhi-8 (LZ-8), from Ganoderma lucidium[J].Journal of Biological Chemistry, 1989, 264(1):472-478.
[27] ZHANG J S, TANG Q J, ZIMMERMAN-KORDMANN M, et al.Activation of B lymphocytes by GLIS, a bioactive proteoglycan from Ganoderma lucidum[J].Life Sciences, 2002, 71(6):623-638.
[28] SA-ARD P, SARNTHIMA R, KHAMMUANG S, et al.Antioxidant, antibacterial and DNA protective activities of protein extracts from Ganoderma lucidum[J].Journal of Food Science and Technology, 2015, 52(5):2 966-2 973.
[29] 李钦艳, 陈逸湘, 钟莹莹.灵芝主要活性成分及其功能的研究进展[J].食药用菌, 2015, 23(2):86-91.
LI Q Y, CHEN Y X, ZHONG Y Y.Research progress on bioactive compounds and their efficacy of Ganoderma lucidum[J].Edible and Medicinal Mushrooms, 2015, 23(2):86-91.
[30] 张圣洁, 郭锦瑞, 康安, 等.肠道菌群对中药糖苷类成分脱糖基代谢的研究进展[J].中国中药杂志, 2013, 38(10):1 459-1 466.
ZHANG S J, GUO J R, KANG A, et al.Advance in studies on gut microbiota in de-glycosylation of traditional Chinese medicine glycosides[J].China Journal of Chinese Materia Medica, 2013, 38(10):1 459-1 466.
[31] 丁翘. 基于肠道菌群探讨黑灵芝多糖对2型糖尿病大鼠的影响机制[D].南昌:南昌大学, 2020.
DING Q.The mechanism of polysaccharides from Ganoderma atrum on type 2 diabetic rats through gut microbiota[D].Nanchang:Nanchang University, 2020.
[32] HU R K, GUO W L, HUANG Z R, et al.Extracts of Ganoderma lucidum attenuate lipid metabolism and modulate gut microbiota in high-fat diet fed rats[J].Journal of Functional Foods, 2018, 46:403-412.
[33] CHANG C J, LIN C S, LU C C, et al.Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota[J].Nature Communications, 2015, 6(1):7489.
[34] CHEN M Y, XIAO D, LIU W, et al.Intake of Ganoderma lucidum polysaccharides reverses the disturbed gut microbiota and metabolism in type 2 diabetic rats[J].International Journal of Biological Macromolecules, 2020,155:890-902.
[35] XU S, DOU Y, YE B, et al.Ganoderma lucidum polysaccharides improve insulin sensitivity by regulating inflammatory cytokines and gut microbiota composition in mice[J].Journal of Functional Foods, 2017, 38:545-552.
[36] GUO W L, PAN Y Y, LI L, et al.Ethanol extract of Ganoderma lucidum ameliorates lipid metabolic disorders and modulates the gut microbiota composition in high-fat diet fed rats[J].Food & Function, 2018, 9(6):3 419-3 431.
[37] 杨开, 张雅杰, 张酥, 等.灵芝孢子粉低聚糖的制备及调节肠道菌群功能研究[J].食品与发酵工业, 2020, 46(9):37-42.
YANG K, ZHANG Y J, ZHANG S, et al.Preparation of Ganoderma lucidum spore oligosaccharide and its regulation on gut microbiota[J].Food and Fermentation Industries, 2020, 46(9):37-42.
[38] SU J Y, LI D, CHEN Q J, et al.Anti-breast cancer enhancement of a polysaccharide from spore of Ganoderma lucidum with paclitaxel:Suppression on tumor metabolism with gut microbiota reshaping[J].Frontiers in Microbiology, 2018, 9:3 099.
[39] 江国勇. 黑灵芝多糖对丙烯酰胺致大鼠肝脏损伤的保护作用研究[D].南昌:南昌大学, 2020.
JIANG G Y.The protective effect of Ganoderma atrum polysaccharide on liver injury induced by acrylamide in rats[D].Nanchang:Nanchang University, 2020.
[40] CANI P D, DELZENNE N M.The role of the gut microbiota in energy metabolism and metabolic disease[J].Current Pharmaceutical Design, 2009, 15(13):1 546-1 558.
[41] 焦佳琪, 肖春, 吴清平, 等.重要食药用菌多糖降血糖分子机制研究进展[J].微生物学通报, 2021, 48(1):197-209.
JIAO J Q, XIAO C, WU Q P, et al.Hypoglycemic effect of important edible and medicinal fungi polysaccharides:A review[J].Microbiology China, 2021, 48(1):197-209.
[42] MENG G L, ZHU H Y, YANG S J, et al.Attenuating effects of Ganoderma lucidum polysaccharides on myocardial collagen cross-linking relates to advanced glycation end product and antioxidant enzymes in high-fat-diet and streptozotocin-induced diabetic rats[J].Carbohydrate Polymers, 2011, 84(1):180-185.
[43] GAO H L, LONG Y Z, JIANG X Q, et al.Beneficial effects of Yerba Mate tea (Ilex paraguariensis) on hyperlipidemia in high-fat-fed hamsters[J].Experimental Gerontology, 2013, 48(6):572-578.
[44] SUN L L, PANG Y Y, WANG X M, et al.Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters[J].Acta Pharmaceutica Sinica B, 2019, 9(4):702-710.
[45] LV X C, GUO W L, LI L, et al.Polysaccharide peptides from Ganoderma lucidum ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet-fed rats[J].Journal of Functional Foods, 2019, 57:48 - 58.
[46] 杨旭. 灵芝多糖及其水解物对免疫抑制小鼠肠粘膜免疫功能的影响[D].西安:陕西师范大学,2019.
YANG X.Effects of polysaccharides and hydrolysates of Ganoderma lucidum on immune function of intestinal mucosa in immunosuppressed mice[D].Xi'an:Shaanxi Normal University,2019.
[47] 沈滟惠, 温亚格, 唐庆九, 等.灵芝抗肿瘤活性及其机制研究进展[J].海峡药学, 2020, 32(4):8-12.
SHEN Y H, WEN Y G, TANG Q J, et al.Review on anti-tumor activity and its mechanisms of Ganoderma[J].Strait Pharmaceutical Journal, 2020, 32(4):8-12.
[48] 梁岚. 灵芝多糖对肿瘤细胞与内皮细胞相互作用的影响[J].中国药房, 2012, 23(43):4 055-4 056.
LIANG L.Effects of Ganoderma lucidum polysaccharides on interaction of endothelial cells with tumor cells[J].China Pharmacy, 2012, 23(43):4 055-4 056.
[49] 唐庆九, 季哲, 郝瑞霞, 等.灵芝中性三萜类成分的抗肿瘤作用[J].食用菌学报, 2010, 17(1):60-64.
TANG Q J, JI Z, HAO R X, et al.Inhibition of tumor cell proliferation by a neutral triterpenoid fraction from Ganoderma lucidum[J].Acta Edulis Fungi, 2010, 17(1):60-64.
[50] 陆慧, 贾晓斌, 陈彦, 等.灵芝甾醇类活性成分及其抗肿瘤作用机制的研究进展[J].中华中医药杂志, 2011, 26(2):325-329.
LU H, JIA X B, CHEN Y, et al.Study on active ingredients from Ganoderma sterols and their anti-tumour mechanisms[J].China Journal of Traditional Chinese Medicine and Pharmacy, 2011, 26(2):325-329.
[51] 张莘莘. 黑灵芝多糖的抗肿瘤活性及其分子机制初探[D].南昌:南昌大学, 2014.
ZHANG X X.Studies on antitumor effect and molecualr mechanism of Ganoderma atrum polysaccharide[D].Nanchang:Nanchang University, 2014.
[52] 徐凤姣, 曾琴, 刘宏壁, 等.灵芝乙醇提取物抗肿瘤活性研究[J].中药药理与临床, 2016, 32(6):127-130.
XU F J, ZENG Q, LIU H B, et al.Studies on anti-tumor activities of ethanol extract of Ganoderma lucidum[J].Pharmacology and Clinics of Chinese Materia Medica, 2016, 32(6):127-130.
[53] 于乐成. 肝细胞损伤和修复研究进展[J].肝脏, 2015, 20(11):883-885.
YU L C.Research progress of hepatocyte injury and repair[J].Chinese Hepatology, 2015, 20 (11):883-885.
[54] ZHU K X, NIE S P, TAN L H, et al.A polysaccharide from Ganoderma atrum improves liver function in type 2 diabetic rats via antioxidant action and short-chain fatty acids excretion[J].Journal of Agricultural and Food Chemistry, 2016, 64(9):1 938-1 944.
[55] 余尊祥, 葛苏云.灵芝及其生化特性[J].云南师范大学学报(自然科学版), 1994, 14(1):77-81.
YU Z X, GE S Y.Biology and chemistry of Ganoderma lucidum(leyss.ex Fr.)Karst[J].Journal of Yunnan Normal University (Natural Sciences Edition), 1994, 14(1):77-81.
[56] 朴玮, 韩枫, 徐维盛, 等.破壁灵芝孢子粉及灵芝提取物的混合物对改善小鼠睡眠功能的研究[J].食品科技, 2015, 40(11):172-175.
PIAO W, HAN F, XU W S, et al.The compound preparation of cracked spores powder and the extracts of ganodorma lucidum on the sleep-improvement function in mice[J].Food Science and Technology, 2015, 40(11):172-175.
