Food and Fermentation Industries >

2022 , Vol. 48 >Issue 12: 46 - 51

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.028424

Optimization and evaluation of preparation of ursolic acid loaded chitosan nanoparticles

  • ZHAO Lujie ,
  • DUAN Xu ,
  • CAO Weiwei ,
  • REN Guangyue ,
  • LIU Panpan ,
  • REN Xing
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  • 1(College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China)
    2(Collaborative Innovation Center of Grain Storage Security, Henan Province, Zhengzhou 450001, China)

Received date: 2021-06-21

  Revised date: 2021-07-23

  Online published: 2022-07-15

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Abstract

The ursolic acid loaded chitosan nanoparticles were prepared by ionic gel method with sodium tripolyphosphate as the cross-linking agent. Based on the single factor and orthogonal experiment, the encapsulation efficiency was used as an evaluation indicator to optimize the preparation parameters of ursolic acid loaded chitosan nanoparticles. Moreover, the particle size and dissolution of ursolic acid nanoparticles under the optimized parameters were also determined. Results showed that the optimum conditions were as follows: the concentration of chitosan solution was 2.0 mg/mL; the mass ratio of chitosan to ursolic acid was 4∶1; the mass ratio of chitosan to sodium tripolyphosphate was 4∶1, and the encapsulation efficiency was 79.52%. The particle size of ursolic acid loaded chitosan nanoparticles was about 180 nm, and the distribution was narrow. Meanwhile, the solubility of ursolic acid could significantly increase. Compared with unencapsulated ursolic acid, the dissolution rate of ursolic acid nanoparticles in the simulated gastrointestinal fluid was increased by 4.7 and 1.1 times, respectively. This study provides reference for enhancing the solubility of ursolic acid.

Key words： chitosan; ursolic acid; nanoparticles; ionic gel method; orthogonal experimental

Cite this article

ZHAO Lujie , DUAN Xu , CAO Weiwei , REN Guangyue , LIU Panpan , REN Xing . Optimization and evaluation of preparation of ursolic acid loaded chitosan nanoparticles[J]. Food and Fermentation Industries, 2022 , 48(12) : 46 -51 . DOI: 10.13995/j.cnki.11-1802/ts.028424

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