Food and Fermentation Industries >

2022 , Vol. 48 >Issue 15: 91 - 97

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.030080

Effects of three kinds of grape vinegar on blood lipid level in rats fed with high-fat diet

  • CHEN Lu ,
  • SHI Jun ,
  • ZHAO Hao ,
  • ZHANG Xiaomeng ,
  • WANG Yanling ,
  • ZHANG Jingjing ,
  • YANG Fan ,
  • LU Haoze ,
  • ZHANG Fengjie ,
  • JIN Weiyun ,
  • YU Jiajun ,
  • XUE jie
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  • 1(College of Food Science and Pharmacy, Xinjiang Agricultural University, Urumqi 830000, China)
    2(China National Research Institute of Food & Fermentation Industries, Beijing 100015, China)
    3(College of Food Science, Tibet Agriculture and Animal Husbandry University, Nyingchi 860000, China)
    4(International Joint Research Center for liquor quality and safety, Beijing 100015, China)

Received date: 2021-11-15

  Revised date: 2021-12-22

  Online published: 2022-09-02

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Abstract

In this paper, three kinds of grape vinegars were used as samples, sample A: grape vinegar (pure grape juice fermentation), sample B: grape vinegar (grape juice∶drug food homology material=1∶1 fermentation) and sample C: commercially available grape vinegar. One hundred and twenty KM male rats were randomly divided into 12 groups and gavaged with saline, fat emulsion and grape vinegar, etc. After eight weeks of continuous gavage, serum and liver biochemical indexes and liver pathological sections were examined. Compared with the model group, the body weight of rats in all groups decreased with different degrees, among which the body weight of rats in samples A and B decreased more in the 5th week to the 7th week; TC and TG indexes decreased, HDL-C increased and LDL-C decreased, among which the difference between sample B and the model group was larger; the increase of ApoA1 indexes and the decrease of ApoB indexes, among which the improvement of sample B was the largest for the two indexes; the decrease of liver mass and liver coefficient of rats, but the decrease pattern did not correlate with the sample and the dose; the liver sections showed that compared with the model group, the amount of sample B and the amount of sample A and C high dose groups were basically different. The hepatocytes in the high dose group of sample B and sample A and C were basically restored to normal, while the hepatocytes in other groups were damaged to different degrees.

Key words： grape vinegar; drug food homology; rat; high fat diet; blood fat; liver

Cite this article

CHEN Lu , SHI Jun , ZHAO Hao , ZHANG Xiaomeng , WANG Yanling , ZHANG Jingjing , YANG Fan , LU Haoze , ZHANG Fengjie , JIN Weiyun , YU Jiajun , XUE jie . Effects of three kinds of grape vinegar on blood lipid level in rats fed with high-fat diet[J]. Food and Fermentation Industries, 2022 , 48(15) : 91 -97 . DOI: 10.13995/j.cnki.11-1802/ts.030080

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