Helicobacter pylori is a common pathogen that infects more than half the global population. It is one of the main pathogenic factors for several gastrointestinal diseases such as peptic ulcer disease, non-ulcer dyspepsia and gastric cancer. Co-aggregation exists among bacteria. It has gradually begun to be used in the treatment of H. pylori infection. The use of co-aggregation to alleviate H. pylori infection has mainly focused on the Limosilactobacillus reuteri DSMZ17648 strain. This research was carried out to investigate the effectiveness of another Lactobacillus with H. pylori co-aggregation ability to alleviate H. pylori infection. Lactobacillus strains were screened through coaggregation assay and cell adhesion assay in vitro, and then assessed their clinical efficacy of it. Thirty-seven subjects completed the clinical study, including 15 in the placebo group and 22 in the intervention group. Subjects were given the probiotics twice daily for 4-week. The clinical results showed that the 14C breath reduction value was significantly improved by the Limosilactobacillus fermentum FBJSYZ21-1 intervention (263.04±179.36,P<0.05), compared to the placebo subjects. Meanwhile, the intervention also reduced the gastrointestinal symptoms and did not affect the basic physiological status of the subjects. Therefore, L. fermentum FBJSYZ21-1 intervention may alleviate the infection and the gastrointestinal symptoms H. pylori caused, and not affect the basic physiological status of the patients.
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