Food and Fermentation Industries >

2023 , Vol. 49 >Issue 2: 218 - 225

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.030751

Distribution of cholesterol and cholesteryl ester in breast milk

  • ZHANG Shuhong ,
  • WANG Longqiong ,
  • DING Desheng ,
  • HE Xiaoling ,
  • CAI Tian ,
  • ZHANG Hua ,
  • CHEN Kewei
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  • 1(College of Food Science, Southwest University, Chongqing 400715, China)
    2(National Demonstration Center for Experimental Food Science and Technology Education, Southwest University, Chongqing 400715, China)
    3(Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China)
    4(School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China)

Received date: 2022-01-08

  Revised date: 2022-02-10

  Online published: 2023-02-15

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Abstract

Breast milk can provide all the nutrition needed for the infant in the first 6 months after birth, and is the best choice for the healthy growth and development of newborns and infants. A systematic qualitative and quantitative analysis of cholesterol and cholesteryl esters in breast milk was conducted byultra-performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS). The composition and content differences of cholesterol and cholesteryl esters in different lactation stages (1-7 d of colostrum, 8-15 d of transition milk, and after 16 d of mature milk) were analyzed. Results showed that besides cholesterol, there were 13, 11, and 7 kinds of trace cholesteryl esters in colostrum, transitional milk, and mature milk, respectively, and the contents of cholesteryl tetracosanoate (C24∶0) and cholesteryl palmitate (C16∶0) were the highest in the whole lactation period. There were big individual differences in the contents of cholesterol and cholesteryl esters in breast milk, but the contents of cholesterol and cholesteryl esters in colostrum werethe highest overall. Furthermore, there was a certain correlation between different cholesteryl esters, especially between the cholesteryl docosenoate (C22∶1) and cholesteryl stearate (C18∶0) (P=0.88). This study could provide a reference for the development of infant formula food.

Key words： breast milk; cholesterol; cholesteryl ester; qualitative analysis; quantitative analysis

Cite this article

ZHANG Shuhong , WANG Longqiong , DING Desheng , HE Xiaoling , CAI Tian , ZHANG Hua , CHEN Kewei . Distribution of cholesterol and cholesteryl ester in breast milk[J]. Food and Fermentation Industries, 2023 , 49(2) : 218 -225 . DOI: 10.13995/j.cnki.11-1802/ts.030751

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