Food and Fermentation Industries >

2023 , Vol. 49 >Issue 3: 182 - 188

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.030292

Optimized preparation, physicochemical properties, and in vitro release research of curcumin loaded corn porous starch microspheres

  • WANG Huayu ,
  • SHEN Chaolu ,
  • YUAN Yue ,
  • WU Xiaoli ,
  • GUAN Jing ,
  • AI Fangbin
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  • 1(School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China)
    2(College of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China)

Received date: 2021-12-01

  Revised date: 2022-01-24

  Online published: 2023-03-03

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Abstract

In this paper, the porous corn starch was used as the carrier and the curcumin-loaded corn porous starch microspheres were prepared by the evaporation solvent method. The optimal preparation conditions of curcumin and corn porous starch were investigated. The curcumin-loaded porous starch microspheres were characterized and analyzed by scanning electron microscope (SEM), brunner emmet teller (BET), Fourier transform infrared spectrometer (FTIR), X-ray diffraction (XRD), differential scanning calorimeter (DSC), and thermogravimetric (TG), to investigate the detailed physical and chemical analysis of microspheres. The release of the microspheres was studied. Results showed that when the mass ratio of curcumin to porous starch was 1∶2.50, the microspheres had (35.22±0.46)% of drug loading and (90.70±0.12)% of entrapment efficiency, which could significantly increase the curcumin in vitro release rate. Various characterization results indicated that curcumin was adsorbed into the pore structure of porous starch and mostly existed in the amorphous structure or the tiny microcrystalline. The adsorption and loading of curcumin not only improved the bio-availability of curcumin but also provided a theoretical and practical basis for promoting the application of insoluble curcumin in the food field.

Key words： curcumin; porous starch; optimized preparation; microspheres; in vitro release

Cite this article

WANG Huayu , SHEN Chaolu , YUAN Yue , WU Xiaoli , GUAN Jing , AI Fangbin . Optimized preparation, physicochemical properties, and in vitro release research of curcumin loaded corn porous starch microspheres[J]. Food and Fermentation Industries, 2023 , 49(3) : 182 -188 . DOI: 10.13995/j.cnki.11-1802/ts.030292

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