To investigate the effect of Xinjiang wine on autophagy of liver and hepatocytes, male SD rats were randomly divided into six groups, including blank group (1), alcohol group (2), Tuha Basin dry white wine group (3), the northern foothill of Tianshan Mountain dry red wine group (4), Yili River Valley dry red wine group (5), and Yanqi Basin dry red wine group (6). After 8 weeks of gavage with Xinjiang wine from different producing areas, the changes of body weight, liver coefficient, pathomorphological changes of liver tissue, the contents of alanine transaminase (ALT) and aspartate aminotransferase (AST) in serum, and the expression levels of autophagy related proteins LC3 and p62 in liver were detected by Western blotting. Results showed that compared with the blank group, the weight growth trend of rats in wine group 3, 4, 5, and 6 was slower, and the weight growth trend of rats in alcohol group was the slowest. Compared with alcohol group, the liver coefficient decreased significantly (P<0.05), and there was no obvious lesion in the liver. Total cholesterol, triglyceride, low density lipoprotein cholesterol, AST, ALT, blood urea nitrogen, serum creatinine, total protein, albumin, globulin, and blood glucose in serum decreased, high density lipoprotein cholesterol has an upward trend(P>0.05), and the content of globulin has no significant difference. LC3 protein content increased and p62 protein content decreased, and all reached a significant levels (P<0.05). Moderate intake of wine can reduce the liver coefficient, regulate the blood clearance index and liver function in rats, and promote the level of hepatocyte autophagy, so as to reduce the damage of alcohol to the liver, which may be related to the phenolic substances contained in wine.
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