Research progress in the antibacterial effect of probiotic metabolites on pathogens

  • ZHANG Xiaoxu ,
  • LIU Huan ,
  • XIAO Miao ,
  • LI Yingyu ,
  • LU Ping ,
  • LI Ying ,
  • SHI Yu ,
  • ZHAO Yanni ,
  • ZENG Qiao ,
  • ZHANG Yafeng
Expand
  • 1(School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China)
    2(Shaanxi Research Institute of Agricultural Products Processing Technology, Xi'an 710021, China)
    3(Xi'an Institute for Food and Drug Control, Xi'an 710054, China)

Received date: 2022-05-27

  Revised date: 2022-06-17

  Online published: 2023-05-16

Abstract

Probiotics are able to produce a variety of metabolites with broad-spectrum antibacterial activity. They can satisfy the people's requirements for greenness and health and are expected to be environment-friendly antimicrobial agents. The metabolites include organic acid, bacteriocin, hydrogen peroxide, etc. They can take antimicrobial actions in different mechanisms. They are able to destroy the structure of cell envelope and affect the membrane potential. They can destroy the biological macromolecules, interfere with cell metabolism, or affect the biological activities of DNA and RNA. Besides, they can also compete for the binding sites of the growth-related substances in pathogens to inhibit cell growth and division. The result is expected to provide a theoretical basis for the wide application of probiotic metabolites as new antimicrobial substances.

Cite this article

ZHANG Xiaoxu , LIU Huan , XIAO Miao , LI Yingyu , LU Ping , LI Ying , SHI Yu , ZHAO Yanni , ZENG Qiao , ZHANG Yafeng . Research progress in the antibacterial effect of probiotic metabolites on pathogens[J]. Food and Fermentation Industries, 2023 , 49(8) : 297 -302 . DOI: 10.13995/j.cnki.11-1802/ts.032474

References

[1] 牟志勇, 杨昳津, 王光强, 等.酵母菌的益生功能及在食品中的应用[J].食品科学, 2021, 42(15):309-318.
MU Z Y, YANG Y J, WANG G Q, et al.Beneficial effects of yeasts and applications in foods[J].Food Science, 2021, 42(15):309-318.
[2] DAWOOD M A O, KOSHIO S, ISHIKAWA M, et al.Effects of dietary supplementation of Lactobacillus rhamnosus or/and Lactococcus lactis on the growth, gut microbiota and immune responses of red sea bream, Pagrus major[J].Fish & Shellfish Immunology, 2016, 49:275-285.
[3] 匡珍, 李学英, 徐春霞, 等.乳酸菌细菌素研究进展及其在水产养殖和加工中的应用[J].食品工业科技, 2019, 40(4):292-298.
KUANG Z, LI X Y, XU C X, et al.Research progress of bacteriocins from lactic acid bacteria and its application in aqua culture and processing[J].Science and Technology of Food Industry, 2019, 40(4):292-298.
[4] 吴阿敏, 张富新, 吴珊, 等.植物乳杆菌对头孢氨苄耐药性进化及益生性状稳定性评价[J].食品与发酵工业, 2022, 48(12):90-96.
WU A M, ZHANG F X, WU S, et al.The resistance evolution of Lactobacillus plantarum to cephalexin and its probiotic properties evaluation[J].Food and Fermentation Industries, 2022, 48(12):90-96.
[5] 王毅超. 肠源益生性抑菌乳酸菌的分离筛选及其抑菌物质的研究[D].哈尔滨:东北农业大学, 2019.
WANG Y C.Screening of beneficial bacteriostatic lactic acid bacteria from intestine and study on bacteriostatic substances[D].Harbin:Northeast Agricultural University, 2019.
[6] SZAJEWSKA H, KOŁODZIEJ M.Systematic review with meta-analysis:Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea in children and adults[J].Alimentary Pharmacology & Therapeutics, 2015, 42(10):1 149-1 157.
[7] 齐康儒. 益生菌抑菌剂制备及应用研究[D].西安:陕西科技大学, 2018.
QI K R.Preparation and application of antimicrobial agents produced by probiotics[D].Xi'an:Shaanxi University of Science & Technology, 2018.
[8] KATHAYAT D, CLOSS G Jr, HELMY Y A, et al.In vitro and in vivo evaluation of Lacticaseibacillus rhamnosus GG and Bifidobacterium lactis Bb12 against avian pathogenic Escherichia coli and identification of novel probiotic-derived bioactive peptides[J].Probiotics and Antimicrobial Proteins, 2022, 14(6):1 012-1 028.
[9] GUIMARÃES A, SANTIAGO A, TEIXEIRA J A, et al.Anti-aflatoxigenic effect of organic acids produced by Lactobacillus plantarum[J].International Journal of Food Microbiology, 2018, 264:31-38.
[10] LE LAY C, COTON E, LE BLAY G, et al.Identification and quantification of antifungal compounds produced by lactic acid bacteria and propionibacteria[J].International Journal of Food Microbiology, 2016, 239:79-85.
[11] 饶瑜, 常伟, 向文良, 等.抗食品腐败酵母的乳酸菌的筛选与鉴定[J].现代食品科技, 2013, 29(8):1 943-1 947.
RAO Y, CHANG W, XIANG W L, et al.Screening and identification of lactic acid bacteria with inhibition activity against food-borne spoilage yeast[J].Modern Food Science and Technology, 2013, 29(8):1 943-1 947.
[12] NING Y W, FU Y N, HOU L L, et al.iTRAQ-based quantitative proteomic analysis of synergistic antibacterial mechanism of phenyllactic acid and lactic acid against Bacillus cereus[J].Food Research International, 2021, 139:109562.
[13] WANG C J, CHANG T, YANG H, et al.Antibacterial mechanism of lactic acid on physiological and morphological properties of Salmonella Enteritidis, Escherichia coli and Listeria monocytogenes[J].Food Control, 2015, 47:231-236.
[14] DE KEERSMAECKER S C J, VERHOEVEN T L A, DESAIR J, et al.Strong antimicrobial activity of Lactobacillus rhamnosus GG against Salmonella typhimurium is due to accumulation of lactic acid[J].FEMS Microbiology Letters, 2006, 259(1):89-96.
[15] OGAWA M, SHIMIZU K, NOMOTO K, et al.Inhibition of in vitro growth of Shiga toxin-producing Escherichia coli O157:H7 by probiotic Lactobacillus strains due to production of lactic acid[J].International Journal of Food Microbiology, 2001, 68(1-2):135-140.
[16] BUKHARI S A, SALMAN M, NUMAN M, et al.Characterization of antifungal metabolites produced by Lactobacillus plantarum and Lactobacillus coryniformis isolated from rice rinsed water[J].Molecular Biology Reports, 2020, 47(3):1 871-1 881.
[17] 马妙莲, 赵静, 陈晓琳, 等.具有广谱抑菌活性乳酸菌的筛选及抑菌物质分析[J].食品科学, 2012, 33(1):162-165.
MA M L, ZHAO J, CHEN X L, et al.Isolation of lactic acid bacteria with broad-spectrum antimicrobial activity and analysis of antimicrobial substances[J].Food Science, 2012, 33(1):162-165.
[18] 郭宇逍, 洪阳, 邓丽莉, 等.苯乳酸对指状青霉的抑菌活性及作用机理[J].食品科学, 2022,43(15):21-27.
GUO Y X, HONG Y, DENG L L, et al.Antifungal activity and possible mechanism of phenylacetic acid against Penicillium digitatum[J].Food Science, 2022,43(15):21-27.
[19] 冀慧颖, 李雪儿, 李明华.苯丙酮酸生物转化产物的抑菌活性研究[J].广州化工, 2020, 48(16):61-63.
JI H Y, LI X E, LI M H.Study on the antimicrobial activity of biotransformation products of phenylpyruvate[J].Guangzhou Chemical Industry, 2020, 48(16):61-63.
[20] OTERO M C, NADER-MACÍAS M E.Inhibition of Staphylococcus aureus by H2O2-producing Lactobacillus gasseri isolated from the vaginal tract of cattle[J].Animal Reproduction Science, 2006, 96(1-2):35-46.
[21] ADETOYE A, PINLOCHE E, ADENIYI B A, et al.Characterization and anti-salmonella activities of lactic acid bacteria isolated from cattle faeces[J].BMC Microbiology, 2018, 18(1):96.
[22] FAYOL-MESSAOUDI D, BERGER C N, COCONNIER-POLTER M H, et al.pH-, Lactic acid-, and non-lactic acid-dependent activities of probiotic Lactobacilli against Salmonella enterica Serovar Typhimurium[J].Applied and Environmental Microbiology, 2005, 71(10):6 008-6 013.
[23] 赵乐, 孟祥晨.转录组测序技术在植物乳杆菌细菌素合成研究中的应用研究进展[J].乳业科学与技术, 2021, 44(5):32-37.
ZHAO L, MENG X C.A review of the application of transcriptome sequencing in research on bacteriocin synthesis by Lactobacillus plantarum[J].Journal of Dairy Science and Technology, 2021, 44(5):32-37.
[24] ANGELOPOULOU A, WARDA A K, O'CONNOR P M, et al.Diverse bacteriocins produced by strains from the human milk microbiota[J].Frontiers in Microbiology, 2020, 11:788.
[25] PENG S D, SONG J J, ZENG W Y, et al.A broad-spectrum novel bacteriocin produced by Lactobacillus plantarum SHY 21-2 from yak yogurt:Purification, antimicrobial characteristics and antibacterial mechanism[J].LWT, 2021, 142:110955.
[26] XIANG Y Z, LI X Y, ZHENG H L, et al.Purification and antibacterial properties of a novel bacteriocin against Escherichia coli from Bacillus subtilis isolated from blueberry ferments[J].LWT, 2021, 146:111456.
[27] PARKS W M, BOTTRILL A R, PIERRAT O A, et al.The action of the bacterial toxin, microcin B17, on DNA gyrase[J].Biochimie, 2007, 89(4):500-507.
[28] VINCENT P A, MORERO R D.The structure and biological aspects of peptide antibiotic microcin J25[J].Current Medicinal Chemistry, 2009, 16(5):538-549.
[29] MARDIROSSIAN M, PÉRÉBASKINE N, BENINCASA M, et al.The dolphin proline-rich antimicrobial peptide Tur1A inhibits protein synthesis by targeting the bacterial ribosome[J].Cell Chemical Biology, 2018, 25(5):530-539.
[30] PEI J J, JIN W G, WANG J Z, et al.Purification and characterization of plantaricin YKX and assessment of its inhibitory activity against Alicyclobacillus spp[J].Frontiers in Microbiology, 2021, 12:783266.
[31] OAKLEY J L, WEISER R, POWELL L C, et al.Phenotypic and genotypic adaptations in Pseudomonas aeruginosa biofilms following long-term exposure to an alginate oligomer therapy[J].mSphere, 2021, 6(1):e01216-e01220.
[32] 黄晓英, 李启明, 吴华星, 等.传统发酵食品中具有抑菌活性乳酸菌筛选及其代谢产物稳定性分析[J].现代食品科技, 2021, 37(11):68-78.
HUANG X Y, LI Q M, WU H X, et al.Screening of traditional fermented food products for lactic acid bacteria with antibacterial activity and stability analysis of their metabolites[J].Modern Food Science and Technology, 2021, 37(11):68-78.
[33] SANTIAGO A J, AHMED M N A, WANG S L, et al.Inhibition and dispersal of Pseudomonas aeruginosa biofilms by combination treatment with escapin intermediate products and hydrogen peroxide[J].Antimicrobial Agents and Chemotherapy, 2016, 60(9):5 554-5 562.
[34] LIU Z J, XU C, TIAN R, et al.Screening beneficial bacteriostatic lactic acid bacteria in the intestine and studies of bacteriostatic substances[J].Journal of Zhejiang University-SCIENCE B, 2021, 22(7):533-547.
[35] HERNANDEZ-VALDES J A, SOLOPOVA A, KUIPERS O P.Development of Lactococcus lactis biosensors for detection of diacetyl[J].Frontiers in Microbiology, 2020, 11:1032.
[36] ROCCHETTI M T, RUSSO P, CAPOZZI V, et al.Bioprospecting antimicrobials from Lactiplantibacillus plantarum:Key factors underlying its probiotic action[J].International Journal of Molecular Sciences, 2021, 22(21):12076.
[37] ANGELIN J, KAVITHA M.Exopolysaccharides from probiotic bacteria and their health potential[J].International Journal of Biological Macromolecules, 2020, 162:853-865.
Outlines

/