Jiangnan University(China) has cooperated with Massey University(New Zealand) to carry out the international undergraduate education project of food science and engineering. The course instructed in English, Food Microbiology and Safety, is one of the core courses of the program. With the guidance of curricular ideological and political, Food Microbiology and Safety experimental course took application as the premise, emphasized the integration of Food Microbiology and Food Safety, and Chinese and foreign teachers cooperated to carry out a series of teaching exploration and practice. The curriculum was designed in the context of food products and food production, took microbial safety as the topic, simulated the real production scene, enriched the connotation, and expanded the extension. Independent designing experiment stimulated subjective initiative and independent planning process exercised overall ability, and online resource platform supported independent learning and evaluation and random grouping cultivated team cooperation ability. The practice showed that the course effectively realized the organic integration of Food Microbiology and Food Safety, the target-driven experimental teaching process was more conducive to stimulate students' initiative, and a large number of comprehensive and designed experiments improved the Profoundness-Innovation-Challenging of the course. Compared with the control class at the same time, the students in this program had stronger professional quality and practical ability, which provided a reference for the teaching reform of other experimental courses in food major.