Transport engineering of the cell factory Corynebacterium glutamicum for bioproduction of amino acids: A review

  • GUAN Dan ,
  • LIANG Qing ,
  • WANG Jian
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  • 1(China Biological Fermentation Industry Association, Beijing 100833, China)
    2(College of Life Sciences, Jilin University, Changchun 130022, China)
    3(College of Biological and Agricultural Engineering, Jilin University, Changchun 130022, China)

Received date: 2022-11-11

  Revised date: 2022-11-19

  Online published: 2023-06-05

Abstract

As an important functional product of the biological manufacturing industry, amino acids have been widely used in food, medicine, animal husbandry, chemical industry and other fields. Corynebacterium glutamicum is a powerful workhorse for amino acid biosynthesis. Therefore, it is of great significance to build an efficient C. glutamicum microbial cell factory for the production of amino acids with high yield, high efficiency, and high conversion rate. Microbial cell factories that produce amino acids efficiently need not only strong anabolic capacity, but also efficient transport capacity. In this review, the research progress of transport engineering to improve substrate uptake and amino acid export, and reabsorption of C. glutamicum is summarized, and the future development direction is prospected.

Cite this article

GUAN Dan , LIANG Qing , WANG Jian . Transport engineering of the cell factory Corynebacterium glutamicum for bioproduction of amino acids: A review[J]. Food and Fermentation Industries, 2023 , 49(9) : 310 -316 . DOI: 10.13995/j.cnki.11-1802/ts.034281

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