[1] 王翔, 卓启云, 吴瑜凡, 等.CRISPR-Cas系统在食源性致病菌中的结构与功能研究进展[J].中国食品学报, 2021, 21(11):329-336.
WANG X, ZHUO Q Y, WU Y F, et al.Research progress on structure and function of CRISPR-Cas systems in foodborne pathogens[J].Journal of Chinese Institute of Food Science and Technology, 2021, 21(11):329-336.
[2] 赵彤. 食源性致病菌检测现状与食品微生物危险性评估[J].中国卫生标准管理, 2019, 10(4):7-9.
ZHAO T.Detection status of foodborne pathogenic bacteria and food microbial risk assessment[J].China Health Standard Management, 2019, 10(4):7-9.
[3] VON EIFF C.Staphylococcus aureus small colony variants:A challenge to microbiologists and clinicians[J].International Journal of Antimicrobial Agents, 2008, 31(6):507-510.
[4] ATALLA H, GYLES C, MALLARD B.Staphylococcus aureus small colony variants (SCVs) and their role in disease[J].Animal Health Research Reviews, 2011, 12(1):33-45.
[5] STONEHAM S M, CANTILLON D M, WADDELL S J, et al.Spontaneously occurring small-colony variants of Staphylococcus aureus show enhanced clearance by THP-1 macrophages[J].Frontiers in Microbiology, 2020, 11:1300.
[6] WISE R I, SPINK W W.The influence of antibiotics on the origin of small colonies (G variants) of Micrococcus pyogenes var.aureus[J].The Journal of Clinical Investigation, 1954, 33(12):1 611-1 622.
[7] MELTER O, RADOJEVIČ B.Small colony variants of Staphylococcusaureus:Review[J].Folia Microbiologica, 2010, 55(6):548-558.
[8] QIAO J J, ZHU M J, FAN Y, et al.Properties and control of cold-induced small colony variants of Staphylococcus aureus[J].Food Bioscience, 2021, 40:100874.
[9] LI W L, LI Y H, WU Y R, et al.Phenotypic and genetic changes in the life cycle of small colony variants of Salmonella enterica serotype Typhimurium induced by streptomycin[J].Annals of Clinical Microbiology and Antimicrobials, 2016, 15(1):37.
[10] REA R, HILL C, GAHAN C G.Listeria monocytogenes PerR mutants display a small-colony phenotype, increased sensitivity to hydrogen peroxide, and significantly reduced murine virulence[J].Applied and Environmental Microbiology, 2005, 71(12):8 314-8 322.
[11] ZHOU S Z, RAO Y F, LI J, et al.Staphylococcus aureus small-colony variants:Formation, infection, and treatment[J].Microbiological Research, 2022, 260:127040.
[12] PROCTOR R A, VON EIFF C, KAHL B C, et al.Small colony variants:A pathogenic form of bacteria that facilitates persistent and recurrent infections[J].Nature Reviews Microbiology, 2006, 4(4):295-305.
[13] TUCHSCHERR L, LÖFFLER B, PROCTOR R A.Persistence of Staphylococcus aureus:Multiple metabolic pathways impact the expression of virulence factors in small-colony variants (SCVs)[J].Frontiers in Microbiology, 2020, 11:1028.
[14] 高硕, 周万青.大肠埃希菌小菌落变异型的特征及临床意义研究进展[J].临床检验杂志, 2019, 37(4):297-300.
GAO S, ZHOU W Q.Research progress on characteristics and clinical significance of Escherichia coli microcolony variant[J].Chinese Journal of Clinical Laboratory Science, 2019, 37(4):297-300.
[15] ALI MIRANI Z, AZIZ M, KHAN S I.Small colony variants have a major role in stability and persistence of Staphylococcus aureus biofilms[J].The Journal of Antibiotics, 2015, 68(2):98-105.
[16] ATALLA H, GYLES C, MALLARD B.Persistence of a Staphylococcus aureus small colony variants (S.aureus SCV) within bovine mammary epithelial cells[J].Veterinary Microbiology, 2010, 143(2-4):319-328.
[17] VESGA O, GROESCHEL M C, OTTEN M F, et al.Staphylococcus aureus small colony variants are induced by the endothelial cell intracellular milieu[J].The Journal of Infectious Diseases, 1996, 173(3):739-742.
[18] MITSUYAMA J, YAMADA H, MAEHANA J, et al.Characteristics of quinolone-induced small colony variants in Staphylococcus aureus[J].Journal of Antimicrobial Chemotherapy, 1997, 39(6):697-705.
[19] SCHMITZ F J, VON EIFF C, GONDOLF M, et al.Staphylococcus aureus small colony variants:Rate of selection and MIC values compared to wild-type strains, using ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and moxifloxacin[J].Clinical Microbiology and Infection:the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 1999, 5(6):376-378.
[20] MORAN J, ADDY M, NEWCOMBE R G, et al.A study to assess the plaque inhibitory action of a newly formulated triclosan toothpaste[J].Journal of Clinical Periodontology, 2001, 28(1):86-89.
[21] GOMEZ ESCALADA M, RUSSELL A D, MAILLARD J Y, et al.Triclosan-bacteria interactions:Single or multiple target sites?[J].Letters in Applied Microbiology, 2005, 41(6):476-481.
[22] FORBES S, LATIMER J, BAZAID A, et al.Altered competitive fitness, antimicrobial susceptibility, and cellular morphology in a triclosan-induced small-colony variant of Staphylococcus aureus[J].Antimicrobial Agents and Chemotherapy, 2015, 59(8):4 809-4 816.
[23] KASTBJERG V G, HEIN-KRISTENSEN L, GRAM L.Triclosan-induced aminoglycoside-tolerant Listeria monocytogenes isolates can appear as small-colony variants[J].Antimicrobial Agents and Chemotherapy, 2014, 58(6):3 124-3 132.
[24] BAYSTON R, ASHRAF W, SMITH T.Triclosan resistance in methicillin-resistant Staphylococcus aureus expressed as small colony variants:A novel mode of evasion of susceptibility to antiseptics[J].Journal of Antimicrobial Chemotherapy, 2007, 59(5):848-853.
[25] KARATZAS K A, ZERVOS A, TASSOU C C, et al.Piezotolerant small-colony variants with increased thermotolerance, antibiotic susceptibility, and low invasiveness in a clonal Staphylococcus aureus population[J].Applied and Environmental Microbiology, 2007, 73(6):1 873-1 881.
[26] CANO D A, PUCCIARELLI M G, MARTÍNEZ-MOYA M, et al.Selection of small-colony variants of Salmonella enterica serovar typhimurium in nonphagocytic eucaryotic cells[J].Infection and Immunity, 2003, 71(7):3 690-3 698.
[27] NAGANO N, KAWAKAMI Y, MATSUMOTO T, et al.Isolation of thymidine-dependent and extended-spectrum-β-lactamase-producing Escherichia coli small-colony variant from urine of a septuagenarian female patient with recurrent cystitis:A case report with genetic investigation[J].Journal of Infection and Chemotherapy, 2020, 26(10):1 066-1 069.
[28] ROGGENKAMP A, SING A, HORNEF M, et al.Chronic prosthetic hip infection caused by a small-colony variant of Escherichia coli[J].Journal of Clinical Microbiology, 1998, 36(9):2 530-2 534.
[29] IRVINE S, BUNK B, BAYES H K, et al.Genomic and transcriptomic characterization of Pseudomonas aeruginosa small colony variants derived from a chronic infection model[J].Microbial Genomics, 2019, 5(4):e000262.
[30] BUI L M G, KIDD S P.A full genomic characterization of the development of a stable Small Colony Variant cell-type by a clinical Staphylococcus aureus strain[J].Infection, Genetics and Evolution, 2015, 36:345-355.
[31] BESIER S, LUDWIG A, OHLSEN K, et al.Molecular analysis of the thymidine-auxotrophic small colony variant phenotype of Staphylococcus aureus[J].International Journal of Medical Microbiology, 2007, 297(4):217-225.
[32] KAHL B C.Small colony variants (SCVs) of Staphylococcus aureus:A bacterial survival strategy[J].Infection, Genetics and Evolution, 2014, 21:515-522.
[33] YAGCI S, HASCELIK G, DOGRU D, et al.Prevalence and genetic diversity of Staphylococcus aureus small-colony variants in cystic fibrosis patients[J].Clinical Microbiology and Infection, 2013, 19(1):77-84.
[34] CHURKINA L N, BIDNENKO S I, LOPES DOS SANTOS SANTIAGO G, et al.Application of the antibiotic batumin for accurate and rapid identification of staphylococcal small colony variants[J].BMC Research Notes, 2012, 5:374.
[35] HUBBARD A T M, BULGASIM I, ROBERTS A P.A novel hemA mutation is responsible for a small-colony-variant phenotype in Escherichia coli[J].Microbiology, 2021, 167(3):000962.
[36] MATSUMOTO T, HASHIMOTO M, TENG C H, et al.Molecular characterization of a carbon dioxide-dependent Escherichia coli small-colony variant isolated from blood cultures[J].International Journal of Medical Microbiology, 2020, 310(5):151431.
[37] ONYANGO L A, DUNSTAN R H, ROBERTS T K, et al.Phenotypic variants of staphylococci and their underlying population distributions following exposure to stress[J].PLoS One, 2013, 8(10):e77614.
[38] KAHL B C, BELLING G, REICHELT R, et al.Thymidine-dependent small-colony variants of Staphylococcus aureus exhibit gross morphological and ultrastructural changes consistent with impaired cell separation[J].Journal of Clinical Microbiology, 2003, 41(1):410-413.
[39] MOISAN H, BROUILLETTE E, JACOB C L, et al.Transcription of virulence factors in Staphylococcus aureus small-colony variants isolated from cystic fibrosis patients is influenced by SigB[J].Journal of Bacteriology, 2006, 188(1):64-76.
[40] MITCHELL G, BROUILLETTE E, SÉGUIN D L, et al.A role for sigma factor B in the emergence of Staphylococcus aureus small-colony variants and elevated biofilm production resulting from an exposure to aminoglycosides[J].Microbial Pathogenesis, 2010, 48(1):18-27.
[41] VANN J M, PROCTOR R A.Cytotoxic effects of ingested Staphylococcus aureus on bovine endothelial cells:Role of S.aureus α-hemolysin[J].Microbial Pathogenesis, 1988, 4(6):443-453.
[42] WANG Y P, LI L, SHEN J Z, et al.Quinolone-resistance in Salmonella is associated with decreased mRNA expression of virulence genes invA and avrA, growth and intracellular invasion and survival[J].Veterinary Microbiology, 2009, 133(4):328-334.
[43] CHEN H B, WANG Q, YIN Y Y, et al.Genotypic variations between wild-type and small colony variant of Staphylococcus aureus in prosthetic valve infectious endocarditis:A comparative genomic and transcriptomic analysis[J].International Journal of Antimicrobial Agents, 2018, 51(4):655-658.
[44] KOHLER C, VON EIFF C, PETERS G, et al.Physiological characterization of a heme-deficient mutant of Staphylococcus aureus by a proteomic approach[J].Journal of Bacteriology, 2003, 185(23):6 928-6 937.
[45] AL-MALEKI A R, VELLASAMY K M, MARIAPPAN V, et al.Transcriptome analysis of Burkholderia pseudomallei SCV reveals an association with virulence, stress resistance and intracellular persistence[J].Genomics, 2020, 112(1):501-512.
[46] AL-MALEKI A R, MARIAPPAN V, VELLASAMY K M, et al.Enhanced intracellular survival and epithelial cell adherence abilities of Burkholderia pseudomallei morphotypes are dependent on differential expression of virulence-associated proteins during mid-logarithmic growth phase[J].Journal of Proteomics, 2014, 106:205-220.
[47] JENUL C, HORSWILL A R.Regulation of Staphylococcus aureus virulence[J].Microbiology Spectrum, 2019, 7(2):10.
[48] SENDI P, PROCTOR R A.Staphylococcus aureus as an intracellular pathogen:The role of small colony variants[J].Trends in Microbiology, 2009, 17(2):54-58
[49] TUCHSCHERR L, LÖFFLER B.Staphylococcus aureus dynamically adapts global regulators and virulence factor expression in the course from acute to chronic infection[J].Current Genetics, 2016, 62(1):15-17.
[50] BISCHOFF M, ENTENZA J M, GIACHINO P.Influence of a functional sigB operon on the global regulators sar and agr in Staphylococcus aureus[J].Journal of Bacteriology, 2001, 183(17):5 171-5 179.
[51] MITCHELL G, FUGÈRE A, PÉPIN GAUDREAU K, et al.SigB is a dominant regulator of virulence in Staphylococcus aureus small-colony variants[J].PLoS One, 2013, 8(5):e65018.
[52] CHATTERJEE I, KRIEGESKORTE A, FISCHER A, et al.In vivo mutations of thymidylate synthase (encoded by thyA) are responsible for thymidine dependency in clinical small-colony variants of Staphylococcus aureus[J].Journal of Bacteriology, 2008, 190(3):834-842.
[53] LOSS G, SIMÕES P M, VALOUR F, et al.Staphylococcus aureus small colony variants (SCVs):News from a chronic prosthetic joint infection[J].Frontiers in Cellular and Infection Microbiology, 2019, 9:363.
[54] KRIEGESKORTE A, KÖNIG S, SANDER G, et al.Small colony variants of Staphylococcus aureus reveal distinct protein profiles[J].Proteomics, 2011, 11(12):2 476-2 490.
[55] TRAN H T, BONILLA C Y.SigB-regulated antioxidant functions in gram-positive bacteria[J].World Journal of Microbiology and Biotechnology, 2021, 37(3):1-10.
[56] SINGH R, RAY P, DAS A, et al.Enhanced production of exopolysaccharide matrix and biofilm by a menadione-auxotrophic Staphylococcus aureus small-colony variant[J].Journal of Medical Microbiology, 2010, 59(Pt 5):521-527.
[57] KIKUCHI M, SUZUKI Y, OKADA S, et al.Septic shock caused by a carbon dioxide-dependent and extended spectrum β-lactamase-producing Proteus mirabilis small colony variant in a long-term bedridden patient[J].Journal of Infection and Chemotherapy, 2022, 28(3):455-458.
[58] MCNAMARA P J, PROCTOR R A.Staphylococcus aureus small colony variants, electron transport and persistent infections[J].International Journal of Antimicrobial Agents, 2000, 14(2):117-122.
[59] BATKO I Z, FLANNAGAN R S, GUARIGLIA-OROPEZA V, et al.Heme-dependent siderophore utilization promotes iron-restricted growth of the Staphylococcus aureus hemB small-colony variant[J].Journal of Bacteriology, 2021, 203(24):e0045821.
[60] BAUMERT N, VON EIFF C, SCHAAFF F, et al.Physiology and antibiotic susceptibility of Staphylococcus aureus small colony variants[J].Microbial Drug Resistance (Larchmont, N.Y.), 2002, 8(4):253-260.
[61] GÓMEZ-GONZÁLEZ C, ACOSTA J, VILLA J, et al.Clinical and molecular characteristics of infections with CO2-dependent small-colony variants of Staphylococcus aureus[J].Journal of Clinical Microbiology, 2010, 48(8):2 878-2 884.