To improve the stability of rose polyphenol, rose polyphenol-chitosan nanoparticles were synthesized by encapsulating rose polyphenol into chitosan by ion crosslinking method. Using encapsulation rate as the evaluation index, the optimal preparation conditions of single factor test were that the mass ratio of chitosan/sodium tripolyphosphate was 2∶1, the volume fraction of acetic acid was 0.5%, the dosage of rose polyphenol was 3 mg/g, under the optimized conditions, encapsulation rate of rose polyphenol reached 94.85%, which was 4.43% higher than before optimization, and rose polyphenol loading rate was 21.26%. Stability experiments showed that rose polyphenols in chitosan nanoparticles were more stable than rose polyphenols under light and air conditions. Results showed that rose polyphenol-chitosan nanoparticles could slow down weight loss, decrease fasting blood glucose, and improve oral glucose tolerance in mice. Furthermore, rose polyphenol-chitosan nanoparticles increased the activities of superoxide dismutase and glutathione peroxidase and decreased the content of malondialde-hyde in mice. These results indicated that the rose polyphenol-chitosan nanoparticles had good antioxidant and hypoglycemic activities. The prepared rose polyphenol-chitosan nanoparticles can not only enhance the bioavailability and stability of rose polyphenols, and also improve their application value, which has a wide application prospect in food, medicine, cosmetics, and other industries.
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