Food and Fermentation Industries >

2023 , Vol. 49 >Issue 15: 336 - 343

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.033046

A review of oral protein nanoparticles constructed by natural polysaccharides

  • CAI Hongying ,
  • TAI Minrui ,
  • LI Rui ,
  • SONG Bingbing ,
  • CHEN Jianping ,
  • LIU Xiaofei ,
  • ZHONG Saiyi
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  • 1(College of Food Science and Technology of Guangdong Ocean University, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Marine Food, Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Guangdong Sub-tropical Fruit and vegetable Processing Technology Innovation Center, Zhanjiang 524088, China)
    2(Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China)

Received date: 2022-07-20

  Revised date: 2022-08-11

  Online published: 2023-08-31

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Abstract

The macromolecules such as proteins and peptides are easily decomposed by protease in the digestive tract, many scholars encapsulate protein by preparing nano-delivery systems to improve the bioavailability of proteins. Natural polysaccharides such as chitosan and starch are macromolecules derived from natural sources, such as plants, microorganisms, and animals. Natural polysaccharides have the advantages of non-toxicity, chemical structure modifiability, and good blood compatibility and biodegradability. They have extensive interactions with living cells, can prolong the resistance time of protein in the gastrointestinal tract, and effectively improve its bioavailability. Therefore, natural polysaccharides as substrates have irreplaceable advantages in the preparation and application of oral protein nano-carrier. This paper mainly introduced the preparation methods of polysaccharide-based oral protein nanoparticles, the main factors affecting the stability of nanoparticles, the commonly used natural polysaccharides for nano-carrier preparation, and their unique advantages compared with other carriers. This paper aimed to provide a theoretical basis for the development of oral delivery carriers of macromolecular protein bioactive substances.

Key words： natural polysaccharide; oral protein; nano-delivery carrier; bioavailability; absorption barriers

Cite this article

CAI Hongying , TAI Minrui , LI Rui , SONG Bingbing , CHEN Jianping , LIU Xiaofei , ZHONG Saiyi . A review of oral protein nanoparticles constructed by natural polysaccharides[J]. Food and Fermentation Industries, 2023 , 49(15) : 336 -343 . DOI: 10.13995/j.cnki.11-1802/ts.033046

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