Ganoderma lucidum has shown a high dual-purpose value in medicine and food, and there are still great prospects for the development of its modern products. Based on the pharmacological and nutritional theories, the research aimed to design a new product with polysaccharide-rich Ganoderma lucidum extract and γ-aminobutyric acid and assessed its effect on sleep improvement. The tablets composed of Ganoderma lucidum polysaccharide and γ-aminobutyric acid were prepared by wet granulation. According to the results of granulation and tableting, as well as the tablet hardness and disintegration time, the optimal formulation was screened out. According to the “Technical Standards for Testing & Assessment of Health Food”, the function assessment for the purpose of verifying its effect on sleep improvement was carried out with SPF mice. Results showed that the optimal prescription consisted of Ganoderma lucidum extract (12.5%,mass fraction), γ-aminobutyric acid (25%), microcrystalline cellulose (32.5%), maltodextrin (13.75%), corn starch (1.25%), croscarmellose sodium (5%), povidone K30 solution (10%) with a concentration of 65%, and magnesium stearate (0.5%). With the procedures of mixing, tableting, and coating, the tan, smooth, and round tablets were obtained. As for the assessment, the tablets significantly prolonged the sleep time of mice treated with pentobarbital sodium in the high-dose and medium-dose groups (P<0.01). Compared to the control group, there was no apparent synergistic effect on subthreshold dose hypnosis with pentobarbital sodium in the three experimental groups. The sleep latency of mice treated with barbital sodium was significantly shortened in the high-dose group (P<0.01). There was no obvious direct sleep effect on mice. It could be concluded that the preparation procedure of the tablets is stable and the qualities of the products are controllable, so it is suitable for industrial production. The functional experimental studies suggest that tablets composed of Ganoderma lucidum polysaccharide and γ-aminobutyric acid contribute to improving the quality of sleep.
LIU Chunfang
,
LIN Yonglu
,
CHEN Liang
,
LI Jing
,
LI Yusheng
,
ZENG Ronghua
,
XU Wendong
. Preparation of tablet composed of Ganoderma lucidum polysaccharide and γ-aminobutyric acid and its assessment of sleep improvement function[J]. Food and Fermentation Industries, 2023
, 49(16)
: 119
-124
.
DOI: 10.13995/j.cnki.11-1802/ts.032114
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