Immunomodulatory effects of Streptococcus thermophilus S131 on RAW264.7 cells of mice

  • LI Xuyang ,
  • GUO Runqing ,
  • LU Jianghao ,
  • YAN Mengjie ,
  • ZHANG Peng ,
  • LIU Mingyue ,
  • YANG Ling
Expand
  • (Hebei Inatural Biotech Co.Ltd., Shijiazhuang 050800, China)

Received date: 2022-10-26

  Revised date: 2022-11-21

  Online published: 2023-09-12

Abstract

This study aims to explore the effects of Streptococcus thermophilus S131 in improving immunity and its mechanism of enhancing immunity. Firstly, the ability of the strain to colonize in intestine and produce exopolysaccharides was evaluated. Then, the effect of the strain on proliferation, phagocytosis, and cytokine secretion of macrophage RAW264.7 (mouse monocyte macrophage leukemia cell) cells was detected by cell experiment. The results showed that S. thermophilus S131 had good adhesion ability and could produce exopolysaccharide, The relative proliferation rate and phagocytosis rate of RAW264.7 cells which treated by S131 were 131.11% and 115.13%, respectively, it can promote cells to secrete tumour necrosis factor-α (TNF-α), interleukin-10 (IL-10) and IL-12. In conclusion, S131 could adhere in intestine and can produce exopolysaccharides.It could activate macrophages and produce physiological inflammatory reaction, improve body immunity, which might be used for the development of immune enhancing functional foods.

Cite this article

LI Xuyang , GUO Runqing , LU Jianghao , YAN Mengjie , ZHANG Peng , LIU Mingyue , YANG Ling . Immunomodulatory effects of Streptococcus thermophilus S131 on RAW264.7 cells of mice[J]. Food and Fermentation Industries, 2023 , 49(16) : 247 -252 . DOI: 10.13995/j.cnki.11-1802/ts.034101

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