Food and Fermentation Industries >

2023 , Vol. 49 >Issue 17: 53 - 61

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.034349

Regulation of bacteria growth of five probiotics and intestinal flora of pregnant women by bound sialic acid of edible bird’s nest

  • LU Peihan ,
  • WU Jianrong ,
  • LIU Xuncai ,
  • HUA Yurong ,
  • ZHAN Xiaobei ,
  • GAO Minjie ,
  • ZHANG Hongtao
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  • 1(Key Laboratory of Carbohydrate Chemistry and Biotechnology, Jiangnan University, Wuxi 214122, China)
    2(Xiamen Yan Palace Seelong Food Co.Ltd.Bird’s Nest Institute, Xiamen 361000, China)
    3(Affiliated Hospital of Jiangnan University, Wuxi 214122, China)

Received date: 2022-11-18

  Revised date: 2022-12-23

  Online published: 2023-09-27

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Abstract

There are bound sialoglycans in dietary mucin from animals, which may have an impact on human nutrition and health. In this work, a sialic acid-rich mucin, edible bird’s nest (EBN) was chosen as the research target. Also, the terminal sialic acid of EBN glycoprotein was removed through acidic treatment, forming acidolysis bird’s nest (ABN) and subject to in vitro digestion separately. The effects of these two types of bird’s nest and N-acetylneuraminic acid on the growth of probiotics and the fecal bacteria of pregnant women in vitro were investigated. Compared with the ABN, EBN and N-Acetylneuraminic acid could improve the growth of Lactobacillus and Bifidobacterium and increase the production of short chain fatty acids. EBN can significantly promote the growth of Akkermansia muciniphila. EBN can also increase the production of acetic acid, propionic acid, and butyric acid within 24 h during the in vitro fermentation of fecal bacteria of healthy women and late pregnant women, especially for the increase of propionic acid. Meanwhile, EBN can also reduce the relative abundance of potential pathogenic bacteria such as Escherichia coli-Shigella, Enterobacter, and Klebsiella, and increase the relative abundance of potential probiotics such as Bacteroides, Faecalibacterium and Coprococuus. EBN had more remarkable effect than ABN in reducing the abundance of pathogenic bacteria and increasing the abundance of probiotics. Therefore, the integrity of bound sialic acid of EBN plays an important role in its biological function.

Key words： edible bird’s nest; sialic acid; probiotics; intestinal flora; short chain fatty acids

Cite this article

LU Peihan , WU Jianrong , LIU Xuncai , HUA Yurong , ZHAN Xiaobei , GAO Minjie , ZHANG Hongtao . Regulation of bacteria growth of five probiotics and intestinal flora of pregnant women by bound sialic acid of edible bird’s nest[J]. Food and Fermentation Industries, 2023 , 49(17) : 53 -61 . DOI: 10.13995/j.cnki.11-1802/ts.034349

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