Blended teaching is an important direction of teaching mode reform in colleges and universities in the future. Food Toxicology is the core course of food quality and safety major, and also an important carrier for implementing the ideological and political teaching of the specialty course. The course team has constructed a five-stage advanced blended teaching mode. The practice showed that through teaching activities, students’ subjectivity and autonomy in learning had been fully developed, students’ collaborative learning and autonomous learning abilities have been developed, students’ vision has been expanded, and a new learning community of teachers and students has been constructed. The organic integration of curriculum ideological and political education and online and offline blended teaching is of great significance to improve the cultivation of college students’ professional knowledge and professional confidence.