Food and Fermentation Industries >

2023 , Vol. 49 >Issue 20: 179 - 187

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.036293

Protective effect of giant salamander peptides-selenium chelate on oxidative stress injury in mice caused by D-galactose

  • ZHAO Shibo ,
  • LIU Junxia ,
  • HE Linlin ,
  • JIANG Pengfei ,
  • CHENG Hu ,
  • JIN Wengang
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  • 1(State Key Laboratory of Qinba Biological Resources and Ecological Environment Jointly Built by Province and Ministry, College of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723001, China)
    2(Shaanxi Key Laboratory of Bio-Resources, Shaanxi University of Technology, Hanzhong 723001, China)
    3(Collaborative Innovation Center for Comprehensive Development of Bio-Resources in Qinba Mountain Area of Southern Shaanxi, Shaanxi University of Technology, Hanzhong 723001, China)
    4(National Engineering Research Center for Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China)
    5(Hanzhong Dragon Mountain Aquaculture Development Co.Ltd., Hanzhong 723001, China)

Received date: 2023-05-29

  Revised date: 2023-07-14

  Online published: 2023-11-20

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Abstract

To study the in vivo antioxidant activity of giant salamander peptide-selenium chelates, a mouse model of oxidative stress injury was established by intraperitoneal injection of D-galactose, the protective effects of different doses of peptides and their peptide-selenium chelates on oxidative stress injury in mice were evaluated. Results showed that both giant salamander peptides and their peptide-selenium chelates could antagonize the atrophy of the liver, spleen, and thymus in mice. After the intervention of different doses of giant salamander peptides and peptide-selenium chelates, the total antioxidant capacity, superoxide dismutase, glutathione, and glutathione peroxidase activities in the serum, liver, heart, and brain tissues of mice were significantly increased (P<0.05). Meanwhile, the contents of malondialdehyde and protein carbonyl groups were decreased (P<0.05). Compared with giant salamander peptides, their peptide-selenium chelates possessed a better protective effect on D-galactose-induced oxidative stress injury in mice and showed stronger antioxidant activity. This study provides valuable references for the development of value-added products based on giant salamander peptides.

Key words： giant salamander; peptide-selenium chelates; oxidative stress; D-galactose; antioxidation

Cite this article

ZHAO Shibo , LIU Junxia , HE Linlin , JIANG Pengfei , CHENG Hu , JIN Wengang . Protective effect of giant salamander peptides-selenium chelate on oxidative stress injury in mice caused by D-galactose[J]. Food and Fermentation Industries, 2023 , 49(20) : 179 -187 . DOI: 10.13995/j.cnki.11-1802/ts.036293

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