Four medicine food homologous natural active ingredients, including blueberry anthocyanins, γ-aminobutyric acid, Eucommia male flower tea, and rice bran fatty alcohol, have been found to have good antioxidant and liver-protective activities, which provide new ideas for the study of the protective effect of acute alcoholic liver injury. The prescription was optimized by investigating the DPPH radical scavenging ability and ABTS cationic radical scavenging ability. The mice were randomly divided into blank control group, model group, and administration group (low dose, high dose). After one week of administration, the mice were given liquor intragastric administration to construct acute alcoholic liver injury model. This study calculated the liver index and detected serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. The contents of malondialdehyde (MDA) and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the liver were investigated. Finally, the morphological changes of liver tissue were analyzed by HE staining. Results showed that prophylactic administration of these four components alleviated liver edema and decreased serum AST and ALT levels. They also increased the activity of SOD and GSH-Px and decrease the level of MDA in the liver. The results of HE staining showed that the liver tissue damage was greatly mitigated in the administration group. Prophylactic administration of drug and food homologous compositions have a better protective effect on acute alcoholic liver injury.
ZHOU Huiyu
,
NIU Liyun
,
LIU Huimeng
,
CHEN Guangrui
,
MENG Zhiyun
,
GAN Hui
,
GU Ruolan
,
WU Zhuona
,
YANG Wenjie
,
DOU Guifang
. Protective effect of medicine food homology compositions on acute alcoholic liver injury in mice[J]. Food and Fermentation Industries, 2023
, 49(20)
: 259
-264
.
DOI: 10.13995/j.cnki.11-1802/ts.033654
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