[1] SOLARTE-TORO J C, CARDONA ALZATE C A.Biorefineries as the base for accomplishing the sustainable development goals (SDGs) and the transition to bioeconomy:Technical aspects, challenges and perspectives [J].Bioresource Technology, 2021, 340:125626.
[2] LIU L, GUAN N Z, LI J H, et al.Development of GRAS strains for nutraceutical production using systems and synthetic biology approaches:Advances and prospects[J].Critical Reviews in Biotechnology, 2017, 37(2):139-150.
[3] MCCARTY N S, LEDESMA-AMARO R.Synthetic biology tools to engineer microbial communities for biotechnology [J].Trends in Biotechnology, 2019, 37(2):181-197.
[4] 周文娟, 付刚, 齐显尼, 等.发酵工业菌种的迭代创制[J].生物工程学报, 2022, 38(11):4 200-4 218.
ZHOU W J, FU G, QI X N, et al.Upgrading microbial strains for fermentation industry[J].Chinese Journal of Biotechnology, 2022, 38(11):4200-4218.
[5] LONG M F, XU M J, ZHANG X A, et al.Synthetic biology and metabolic engineering for amino acid production in Corynebacterium glutamicum[J].Scientia Sinica Vitae, 2019, 49(5):541-552.
[6] AHMAR S, GILL R A, JUNG K H, et al.Conventional and molecular techniques from simple breeding to speed breeding in crop plants:Recent advances and future outlook[J].International Journal of Molecular Sciences, 2020, 21(7):2590.
[7] 上官玲玲, 卢慧芳, 夏会丽, 等.谷氨酸棒杆菌细胞工厂构建与应用的研究进展[J].食品与发酵工业, 2022, 48(17):313-320.
SHANGGUAN L L, LU H F, XIA H L, et al.Research progress on construction and application of Corynebacterium glutamicum cell factory[J].Food and Fermentation Industries, 2022, 48(17):313-320.
[8] ZHA J, ZHAO Z, XIAO Z Y, et al.Biosystem design of Corynebacterium glutamicum for bioproduction[J].Current Opinion in Biotechnology, 2023, 79:102870.
[9] LEE J Y, NA Y A, KIM E, et al.The actinobacterium Corynebacterium glutamicum, an industrial workhorse[J].Journal of Microbiology and Biotechnology, 2016, 26(5):807-822.
[10] DO CARMO FÉLIX F K, LETTI L A, VINÍCIUS DE MELO PEREIRA G, et al.L-lysine production improvement:A review of the state of the art and patent landscape focusing on strain development and fermentation technologies[J].Critical Reviews in Biotechnology, 2019, 39(8):1031-1055.
[11] YANG H Q, QU J F, ZOU W, et al.An overview and future prospects of recombinant protein production in Bacillus subtilis[J].Applied Microbiology and Biotechnology, 2021, 105(18):6607-6626.
[12] YU Q H, LI Y C, WU B, et al.Novel mutagenesis and screening technologies for food microorganisms:Advances and prospects[J].Applied Microbiology and Biotechnology, 2020, 104(4):1517-1531.
[13] 陈晓博, 罗雪粤, 张淑荣, 等.生产L-精氨酸的脯氨酸营养缺陷型菌株的选育[J].北京化工大学学报(自然科学版), 2011, 38(6):83-86.
CHEN X B, LUO X Y, ZHANG S R, et al.Screening of a L-arginine producing mutant(D-Argr) with a proline auxotroph[J].Journal of Beijing University of Chemical Technology (Natural Science Edition), 2011, 38(6):83-86.
[14] RAINA A, WANI M R, LASKAR R A, et al.Chemical mutagenesis:Role in breeding and biofortification of lentil (Lens culinaris Medik) mutant lines[J].Molecular Biology Reports, 2022, 49(12):11313-11325.
[15] ZHANG Y, ZHANG X H, XIAO S Y, et al.Engineering Corynebacterium glutamicum mutants for 3-methyl-L-butanol production[J].Biochemical Genetics, 2019, 57(3):443-454.
[16] DONG Y T, MIAO R Y, FENG R C, et al.Edible and medicinal fungi breeding techniques, a review:Current status and future prospects[J].Current Research in Food Science, 2022, 5:2070-2080.
[17] 张婧芳, 汪江波, 黄金明, 等.L-鸟氨酸高产菌的原生质体融合育种[J].氨基酸和生物资源, 2009, 31(1):53-57;75.
ZHANG J F, WANG J B, HUANG J M, et al.Breeding of high-yield L-ornithine-producing strain by protoplast fusion[J].Amino Acids & Biotic Resources, 2009, 31(1):53-57;75.
[18] PARK S H, KIM H U, KIM T Y, et al.Metabolic engineering of Corynebacterium glutamicum for L-arginine production [J].Nature Communications, 2014, 5:4618.
[19] WANG Y, ZHENG P, SUN J B.Recent advances in developing enabling technologies for Corynebacterium glutamicum metabolic engineering [J].Chinese Journal of Biotechnology, 2021, 37(5):1603-1618.
[20] BLEISCH R, FREITAG L, IHADJADENE Y, et al.Strain development in microalgal biotechnology-random mutagenesis techniques[J].Life, 2022, 12(7):961.
[21] HU W, LI W, CHEN J.Recent advances of microbial breeding via heavy-ion mutagenesis at IMP [J].Letters in Applied Microbiology, 2017, 65(4):274-280.
[22] 缪建顺, 曹国珍, 张苗苗, 等.重离子束诱变选育谷氨酸高产菌株[J].辐射研究与辐射工艺学报, 2015, 33(5):39-45.
MIAO J S, CAO G Z, ZHANG M M, et al.High-yield glutamic acid strain screened by heavy ion irradiation[J].Journal of Radiation Research and Radiation Processing, 2015, 33(5):39-45.
[23] ZHANG X, ZHANG X F, LI H P, et al.Atmospheric and room temperature plasma (ARTP) as a new powerful mutagenesis tool [J].Applied Microbiology and Biotechnology, 2014, 98(12):5387-5396.
[24] ZHAO Z Q, CAI M M, LIU Y R, et al.Genomics and transcriptomics-guided metabolic engineering Corynebacterium glutamicum for L-arginine production [J].Bioresource Technology, 2022, 364:128054.
[25] LV Q L, HU M K, TIAN L Z, et al.Enhancing L-glutamine production in Corynebacterium glutamicum by rational metabolic engineering combined with a two-stage pH control strategy[J].Bioresource Technology, 2021, 341:125799.
[26] STELLA R G, WIECHERT J, NOACK S, et al.Evolutionary engineering of Corynebacterium glutamicum [J].Biotechnology Journal 2019, 14(9):e1800444.
[27] TUYISHIME P, WANG Y, FAN L W, et al.Engineering Corynebacterium glutamicum for methanol-dependent growth and glutamate production[J].Metabolic Engineering, 2018, 49:220-231.
[28] KRÜGER A, FRUNZKE J.A pseudokinase version of the histidine kinase ChrS promotes high heme tolerance of Corynebacterium glutamicum[J].Frontiers in Microbiology, 2022, 13:997448.
[29] 徐美娟, 上官春雨, 陈鑫, 等.谷氨酸棒杆菌耐受胁迫机制及工业鲁棒性合成生物学研究进展[J].生物工程学报, 2021, 37(3):831-845.
XU M J, SHANGGUAN C Y, CHEN X, et al.Advances in stress tolerance mechanisms and synthetic biology for the industrial robustness of Corynebacterium glutamicum[J].Chinese Journal of Biotechnology, 2021, 37(3):831-845.
[30] JIANG Y, SHENG Q, WU X Y, et al.L-arginine production in Corynebacterium glutamicum:Manipulation and optimization of the metabolic process[J].Critical Reviews in Biotechnology, 2021, 41(2):172-185.
[31] 田荣臻, 刘延峰, 李江华, 等.典型模式微生物基因表达精细调控工具的研究进展[J].合成生物学, 2020, 1(4):454-469.
TIAN R Z, LIU Y F, LI J H, et al.Progress in the regulatory tools of gene expression for model microorganisms[J].Synthetic Biology Journal, 2020, 1(4):454-469.
[32] WEN J B, BAO J.Engineering Corynebacterium glutamicum triggers glutamic acid accumulation in biotin-rich corn stover hydrolysate [J].Biotechnology for Biofuels, 2019, 12:86.
[33] WANG Y Y, ZHANG F, XU J Z, et al.Improvement of L-leucine production in Corynebacterium glutamicum by altering the redox flux[J].International Journal of Molecular Sciences, 2019, 20(8):2020.
[34] 高聪, 陈城虎, 陈修来, 等.代谢工程改造微生物合成生物基单体的进展与挑战 [J].化工进展:1-13.
GAO C, CHEN C H, CEHN X L, et al.Progress and challenges of engineering microorganisms to produce biobased monomers [J].Chemical Industry and Engineering Progress:1-13.
[35] 朱欣娜, 戴住波, 樊飞宇,等.微生物细胞工厂[J].科学通报,2023, 68(13):1626-1636.
ZHU X, DAI Z, FAN F, et al.Microbial cell factories [J].Chinese Science Bulletin, 2023, 68(13):1626-1636.
[36] XU J Z, YANG H K, LIU L M, et al.Rational modification of Corynebacterium glutamicum dihydrodipicolinate reductase to switch the nucleotide-cofactor specificity for increasing L-lysine production [J].Biotechnology and Bioengineering, 2018, 115(7):1764-1777.
[37] MANGHWAR H, LINDSEY K, ZHANG X L, et al.CRISPR/Cas system:Recent advances and future prospects for genome editing[J].Trends in Plant Science, 2019, 24(12):1102-1125.
[38] LIU J, LIU M S, SHI T, et al.CRISPR-assisted rational flux-tuning and arrayed CRISPRi screening of an L-proline exporter for L-proline hyperproduction[J].Nature Communications, 2022, 13:891.
[39] SUN D H, CHEN J Z, WANG Y, et al.Metabolic engineering of Corynebacterium glutamicum by synthetic small regulatory RNAs[J].Journal of Industrial Microbiology & Biotechnology, 2019, 46(2):203-208.
[40] SARNAIK A, LIU A, NIELSEN D, et al.High-throughput screening for efficient microbial biotechnology [J].Current Opinion in Biotechnology, 2020, 64:141-150.
[41] CZERNIECKI S M, CRUZ N M, HARDER J L, et al.High-throughput screening enhances kidney organoid differentiation from human pluripotent stem cells and enables automated multidimensional phenotyping[J].Cell Stem Cell, 2018, 22(6):929-940.e4.
[42] RAJ K, VENAYAK N, DIEP P, et al.Automation assisted anaerobic phenotyping for metabolic engineering[J].Microbial Cell Factories, 2021, 20(1):184.
[43] VITELLI M, BUDMAN H, PRITZKER M, et al.Applications of flow cytometry sorting in the pharmaceutical industry:A review [J].Biotechnology Progress, 2021, 37(4):e3146.
[44] ZHANG X, ZHANG X M, XU G Q, et al.Integration of ARTP mutagenesis with biosensor-mediated high-throughput screening to improve L-serine yield in Corynebacterium glutamicum[J].Applied Microbiology and Biotechnology, 2018, 102(14):5939-5951.
[45] TEREKHOV S S, SMIRNOV I V, STEPANOVA A V, et al.Microfluidic droplet platform for ultrahigh-throughput single-cell screening of biodiversity [J].Proceedings of the National Academy of Sciences of the United States of America, 2017, 114(10):2550-2555.
[46] AMIRIFAR L, BESANJIDEH M, NASIRI R, et al.Droplet-based microfluidics in biomedical applications [J].Biofabrication, 2022, 14(2).doi:10.1088/1 758-5090/ac39a9.
[47] JIANG J J, YANG G Y, MA F Q.Fluorescence coupling strategies in fluorescence-activated droplet sorting (FADS) for ultrahigh-throughput screening of enzymes, metabolites, and antibodies[J].Biotechnology Advances, 2023, 66:108173.
[48] JIAN X J, GUO X J, WANG J, et al.Microbial microdroplet culture system (MMC):An integrated platform for automated, high-throughput microbial cultivation and adaptive evolution[J].Biotechnology and Bioengineering, 2020, 117(6):1724-1737.
[49] 邓磊, 张豪, 郑穗平.常压室温等离子体诱变与微生物液滴培养系统联用筛选L-组氨酸产生菌[J].中国酿造, 2021, 40(2):53-58.
DENG L, ZHANG H, ZHENG S P.Screening of L-histidine producing strain based on ARTP mutagenesis combined with microbial microdroplet culture system[J].China Brewing, 2021, 40(2):53-58.
[50] YU X Y, LI S, FENG H B, et al.CRISPRi-microfluidics screening enables genome-scale target identification for high-titer protein production and secretion[J].Metabolic Engineering, 2023, 75:192-204.
[51] YU W W, XU X H, JIN K, et al.Genetically encoded biosensors for microbial synthetic biology:From conceptual frameworks to practical applications[J].Biotechnology Advances, 2023, 62:108077.
[52] STELLA R G, GERTZEN C G W, SMITS S H J, et al.Biosensor-based growth-coupling and spatial separation as an evolution strategy to improve small molecule production of Corynebacterium glutamicum [J].Metabolic Engineering, 2021, 68:162-173.
[53] TAN S Y, SHI F, LIU H Y, et al.Dynamic control of 4-hydroxyisoleucine biosynthesis by modified L-isoleucine biosensor in recombinant Corynebacterium glutamicum[J].ACS Synthetic Biology, 2020, 9(9):2378-2389.
[54] 袁姚梦, 邢新会, 张翀.微生物细胞工厂的设计构建:从诱变育种到全基因组定制化创制[J].合成生物学, 2020, 1(6):656-673.
YUAN Y M, XING X H, ZHANG C.Progress and prospective of engineering microbial cell factories:From random mutagenesis to customized design in genome scale[J].Synthetic Biology Journal, 2020, 1(6):656-673.
[55] 赵国屏. 合成生物学:从“造物致用”到产业转化[J].生物工程学报, 2022, 38(11):4001-4011.
ZHAO G P.Synthetic biology:From “build-for-use” to commercialization[J].Chinese Journal of Biotechnology, 2022, 38(11):4001-4011.