Research progress on breeding strategy of Corynebacterium glutamicum cell factory and high-throughput screening technology

  • LI Ye ,
  • MENG Lihong ,
  • YAN Hao ,
  • BAI Zhonghu
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  • 1(School of Biotechnology, Jiangnan University, Wuxi 214122, China)
    2(National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China)
    3(Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518000, China)

Received date: 2023-07-08

  Revised date: 2023-07-28

  Online published: 2023-12-08

Abstract

Corynebacterium glutamicum is a green and efficient chassis microorganism developed to produce amino acids and many high-value-added products. Designing and constructing efficient industrial microbial cell factories is an important basis for green biomanufacturing, and it is also one of the important ways to promote the goal of “carbon neutrality.” Microbial breeding and high-throughput screening technologies are important directions for creating efficient microbial cell factories and technological innovations in the bioindustry. This paper reviews the recent progress of the breeding strategy and high-throughput screening technology of the C. glutamicum cell factory. Representative examples are discussed, but these novel strategies are highly potential, and thus can be applied to efficiently produce more value-added products by this robust workhorse in industry.

Cite this article

LI Ye , MENG Lihong , YAN Hao , BAI Zhonghu . Research progress on breeding strategy of Corynebacterium glutamicum cell factory and high-throughput screening technology[J]. Food and Fermentation Industries, 2023 , 49(21) : 276 -283 . DOI: 10.13995/j.cnki.11-1802/ts.036707

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