Food and Fermentation Industries >

2023 , Vol. 49 >Issue 23: 84 - 88

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.027804

Proportion of flaxseed oil and krill oil and its effect on hyperlipidemia

  • GAO Yi ,
  • XI Wentao ,
  • ZHAI Lei
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  • (China National Research Institute of Food and Fermentation Industries Co.Ltd.,Beijing 100015, China)

Received date: 2021-03-20

  Revised date: 2021-04-10

  Online published: 2024-01-02

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Abstract

To investigate the hypolipidemic effect of flaxseed oil krill oil with different proportions, 80 male rats were randomly divided into 8 groups, including the blank group, model control group, and flaxseed oil and krill oil (46:50, 62:34, and 78:18) with different ratios in high and low dose groups. The rats were fed a high-fat diet for 7 days and orally treated with different doses of flaxseed oil and krill oil with different ratios for 30 days. The serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in each group were detected to evaluate the efficacy of flaxseed oil krill oil in alleviating hyperlipidemia and optimal ratio of different functional components. Results indicated that compared with the blank control group, the serum TC, TG, and LDL-C contents in the model group were significantly increased (P<0.01), indicating that the model was established. Compared with the model control group, the contents of TC, TG, and LDL-C in different dosage groups were significantly decreased (P<0.05 and P<0.01), and there were no significant differences in body weight and HDL-C in different dosage groups, which showed that flaxseed oil krill oil with different ratios had assistant hypolipidemic effect. When the ratio of flaxseed oil to krill oil was 62:34, the decrease of TG and LDL-C in hyperlipidemia rats was the most significant.

Key words： flaxseed oil; krill oil; hyperlipidemia; different ratios

Cite this article

GAO Yi , XI Wentao , ZHAI Lei . Proportion of flaxseed oil and krill oil and its effect on hyperlipidemia[J]. Food and Fermentation Industries, 2023 , 49(23) : 84 -88 . DOI: 10.13995/j.cnki.11-1802/ts.027804

References

[1] PELLICCIA F, MARAZZI G, GRECO C, et al.Current evidence and future perspectives on n-3 PUFAs[J].International Journal of Cardiology, 2013, 170(2):S3-S7.
[2] 舒奕, 臧佳辰, 郭艾, 等.ω-3多不饱和脂肪酸分离纯化以及生理功能研究进展[J].食品研究与开发, 2014, 35(14):115-119.
SHU Y, ZANG J C, GUO A, et al.Progress in purification and physiological function of ω-3 polyunsaturated fatty acids[J].Food Research and Development, 2014, 35(14):115-119.
[3] SCHUCHARDT J P, NEUBRONNER J, BLOCK R C, et al.Associations between omega-3 index increase and triacylglyceride decrease in subjects with hypertriglyceridemia in response to six month of EPA and DHA supplementation[J].Prostaglandins, Leukotrienes and Essential Fatty Acids, 2014, 91(4):129-134.
[4] 杨敏, 魏冰, 孟橘, 等.ω-3多不饱和脂肪酸的来源及生理功能研究进展[J].中国油脂, 2019, 44(10):110-115.
YANG M, WEI B, MENG J, et al.Progress in sources and physiological function of ω-3 polyunsaturated fatty acids[J].China Oils and Fats, 2019, 44(10):110-115.
[5] 祁惠芳, 程子良, 孔维宝, 等.亚麻籽有效成分的提取及其综合利用研究进展[J].中国油脂, 2019, 44(11):102-107.
QI H F, CHENG Z L, KONG W B, et al.Progress in extraction and comprehensive utilization of effective components in flaxseed[J].China Oils and Fats, 2019, 44(11):102-107.
[6] 施佳慧, 吕桂善, 徐同成, 等.磷虾油的脂肪酸成分及其降血脂功能研究[J].营养学报, 2008, 30(1):115-116.
SHI J H, LYU J S, XU T C, et al.Study on fatty acids components and the hypolipidemic activity of superba oil[J].Acta Nutrimenta Sinica, 2008, 30(1):115-116.
[7] HALS P A, WANG X L, XIAO Y F.Effects of a purified krill oil phospholipid rich in long-chain omega-3 fatty acids on cardiovascular disease risk factors in non-human primates with naturally occurring diabetes type-2 and dyslipidemia[J].Lipids in Health and Disease, 2017, 16(1):11.
[8] ZHOU D Y, LIU Y X, XU Z L, et al.Effects of long-term intake of Antarctic krill oils on artery blood pressure in spontaneously hypertensive rats[J].Journal of the Science of Food and Agriculture, 2017, 97(4):1143-1148.
[9] 黄莉, 闫实, 孙晓璐, 等.亚麻籽油对小鼠免疫功能的影响[J].中国油脂, 2020, 45(12):56-59;99.
HUANG L, YAN S, SUN X L, et al.Effect of flaxseed oil on immune function of mice[J].China Oils and Fats, 2020, 45(12):56-59;99.
[10] SHRAMKO V S, POLONSKAYA Y V, KASHTANOVA E V, et al.The short overview on the relevance of fatty acids for human cardiovascular disorders [J].Biomolecules, 2020, 10(8):1127.
[11] 彭飞城, 李茂星, 王蓉蓉.大豆磷脂软胶囊辅助降血脂功能研究[J].食品安全质量检测学报, 2018, 9(19):5184-5186.
PENG F C, LI M X, WANG R R.Function of granulesten soft capsule in reducing blood lipid[J].Journal of Food Safety & Quality, 2018, 9(19):5184-5186.
[12] 黄庆德, 刘列刚, 郭萍梅, 等.亚麻籽油降脂作用的实验研究[J].食品科学, 2004, 25(3):162-165.
HUANG Q D, LIU L G, GUO P M, et al.Study on the reducing blood lipids of flaxseed oil[J].Food Science, 2004, 25(3):162-165.
[13] 赵媛媛, 覃骊兰, 郝二伟.高血脂症动物模型研究进展[J].中国实验方剂学杂志, 2018, 24(18):215-221.
ZHAO Y Y, QIN L L, HAO E W.Progress of research on animal model of hyperlipidemia[J].Chinese Journal of Experimental Traditional Medical Formulae, 2018, 24(18):215-221.
[14] 赵鹏, 姚思宇, 刘荣珍, 等.γ-亚麻酸降血脂的动物实验研究[J].中国热带医学, 2004, 4(5):722-723;728.
ZHAO P, YAO S Y, LIU R Z, et al.Experimental study on the effect of γ-linolenic acid in reducing blood lipids in animals[J].China Tropical Medicine, 2004, 4(5):722-723;728.
[15] WU D, MEYDANI S, MEYDANI M, et al.Immunologic effects of marine- and plant-derived n-3 polyunsaturated fatty acids in nonhuman primates[J].The American Journal of Clinical Nutrition, 1996, 63(2):273-280.
[16] 林非凡, 谭竹钧.亚麻籽油中α-亚麻酸降血脂功能研究[J].中国油脂, 2012, 37(9):44-47.
LIN F F, TAN Z J.Lipid-lowering function of α-linolenic acid in linseed oil[J].China Oils and Fats, 2012, 37(9):44-47.
[17] 胡晓军, 郭忠贤, 赵毅.亚麻籽油降血脂作用的研究[J].粮食加工, 2005, 30(3):49-51.
HU X J, GUO Z X, ZHAO Y.Study on the hypolipidemic effect of linseed oil[J].Grain Processing, 2005, 30(3):49-51.
[18] 邓乾春, 樊柏林, 黄凤洪, 等.亚麻籽油调和油对高脂模型大鼠的降脂作用[J].食品研究与开发, 2011, 32(2):163-167.
DENG Q C, FAN B L, HUANG F H, et al.Lipid lowering effect of flaxseed oil-based blend oil on high-fat rats[J].Food Research and Development, 2011, 32(2):163-167.
[19] 毛艺, 赵鹏飞, 韩君英, 等.两种化学结构的亚麻酸降低血脂的动物实验研究[J].山西医药杂志, 2018, 47(18):2148-2150.
MAO Y, ZHAO P F, HAN J Y, et al.Animal experimental study on reducing blood lipid by linolenic acid with two chemical structures[J].Shanxi Medical Journal, 2018, 47(18):2148-2150.
[20] XIE D, JIN J, SUN J, et al.Comparison of solvents for extraction of krill oil from krill meal:Lipid yield, phospholipids content, fatty acids composition and minor components [J].Food Chemistry, 2017, 233:434-441.
[21] 贺瑞坤, 罗海吉.南极磷虾油对人类健康的作用[J].食品研究与开发, 2013, 34(20):130-133.
HE R K, LUO H J.Health benefits of Antarctic krill oil[J].Food Research and Development, 2013, 34(20):130-133.
[22] TANDY S, CHUNG R W S, WAT E, et al.Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice[J].Journal of Agricultural and Food Chemistry, 2009, 57(19):9339-9345.
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