Oral antibiotic administration alters the composition of the intestinal microbiota. In this study, we examined the effects of antibiotics of different antimicrobial profiles on intestinal dynamics, intestinal structure, and intestinal nerves in mice. Then we evaluated the repair potential of different sources of bifidobacteria on intestinal structure, function, and intestinal nerve damage caused by broad-spectrum antibiotics in mice. Firstly, antibiotics inhibiting G+ bacteria (ampicillin), antibiotics inhibiting G- bacteria (gentamicin), and broad-spectrum antibiotics were applied to treat mice for 21 days, and small intestinal length, colonic length, cecum weight, small intestinal propulsion rate, whole intestinal transit time, and colonic enteric nerve indices were examined. The results showed that gentamicin-treated group had significantly greater effects on intestinal structure, function, and enteric neurological effects were significantly greater than those of the remaining two groups. Secondly, three strains of Bifidobacterium bifidum were applied to the broad-spectrum antibiotic-treated group for 7 days, and the effects of them on intestinal dynamics, intestinal structure and the nervous system of mice were examined, and the results showed that B. bifidum 45M3 repaired the damage to intestinal structure and function caused by broad-spectrum antibiotics by modulating the intestinal biological barrier. In conclusion, antibiotics with different antimicrobial profiles have different effects on intestinal structure, intestinal dynamics and intestinal nerves in mice, among which antibiotics that inhibit G- bacteria have the greatest effect, while B. bifidum 45M3 has the potential to repair the structural and functional damage to the intestine caused by broad-spectrum antibiotics. This study provides a theoretical basis for probiotic supplementation after taking antibiotics and a new idea for developing new functional foods to enhance citizen’s health.
YU Qiangqing
,
TANG Nan
,
WANG Jialiang
,
MEI Chunxia
,
WANG Linlin
,
WANG Gang
,
ZHANG Hao
,
ZHAO Jianxin
. Bifidobacterium bifidum modulates the intestinal biological barrier to improve antibiotic-induced intestinal dynamics and structural impairment[J]. Food and Fermentation Industries, 2023
, 49(24)
: 21
-28
.
DOI: 10.13995/j.cnki.11-1802/ts.035073
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