Food and Fermentation Industries >

2024 , Vol. 50 >Issue 1: 98 - 104

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.034345

Properties of casein micelle/poly (lactic acid) electrospinning composite fiber membrane and its loading capacity for baicalin

  • ZHEN Chenbo ,
  • YANG Min ,
  • QIN Juanjuan ,
  • ZHENG Jie ,
  • LIAO Haizhou ,
  • WEI Yanming
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  • 1(College of Science, Gansu Agricultural University, Lanzhou 730070, China)
    2(College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China)

Received date: 2022-11-18

  Revised date: 2022-12-13

  Online published: 2024-01-31

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Abstract

Baicalin is a kind of flavonoids, which has anti-inflammatory, antibacterial, antiviral, and other pharmacological effects, but it has poor water solubility and low bioavailability. To improve the water solubility of baicalin, a casein micelle/poly (lactic acid) composite fiber membrane loaded with baicalin was prepared by electrospinning technology. The microstructure, hydrophobicity, solubility, and in vitro release of baicalin were studied. Results showed that baicalin had little effect on the microstructure of the fibers. With the increase in the ratio of casein micelles, the fiber diameter decreased and the fiber-forming performance decreased. When the mass ratio of casein micelles to poly (lactic acid) reached 2∶1, the fiber diameter was the smallest and the fiber-forming ability was better. The results of infrared spectroscopy and X-ray diffraction showed that baicalin was encapsulated in the fibers. Moreover, casein micelles improved the swelling and degradation rate of poly (lactic acid) fiber membranes. With the increase of casein micelles, the hydrophilicity and degradation rate of the membrane were enhanced, and the swelling rate and swelling time were reduced. In vitro release results showed that the casein micelle-poly (lactic acid) fiber membrane had a good controlled release effect on baicalin. The results can provide a reference for the load of baicalin.

Key words： electrospinning; baicalin; polylactic acid; casein micelles; composite fiber membrane

Cite this article

ZHEN Chenbo , YANG Min , QIN Juanjuan , ZHENG Jie , LIAO Haizhou , WEI Yanming . Properties of casein micelle/poly (lactic acid) electrospinning composite fiber membrane and its loading capacity for baicalin[J]. Food and Fermentation Industries, 2024 , 50(1) : 98 -104 . DOI: 10.13995/j.cnki.11-1802/ts.034345

References

[1] YANG J Y, LI M, ZHANG C L, et al.Pharmacological properties of baicalin on liver diseases:A narrative review[J].Pharmacological Reports, 2021, 73(5):1230-1239.
[2] CHEN Y, YUAN W J, YANG Y H, et al.Inhibition mechanisms of baicalin and its phospholipid complex against DHAV-1 replication[J].Poultry Science, 2018, 97:3816-3825.
[3] LI J, JIANG Q H, DENG P, et al.The formation of a host-guest inclusion complex system between β-cyclodextrin and baicalin and its dissolution characteristics[J].The Journal of Pharmacy and Pharmacology, 2017, 69(6):663-674.
[4] DOSHI J, RENEKER D H.Electrospinning process and applications of electrospun fibers[J].Journal of Electrostatics, 1995, 35(2-3):151-160.
[5] HUANG H, SONG Y D, ZHANG Y Q, et al.Electrospun nanofibers:Current progress and applications in food systems[J].Journal of Agricultural and Food Chemistry, 2022, 70(5):1391-1409.
[6] CHEN X, LI H H, LU W P, et al.Antibacterial porous coaxial drug-carrying nanofibers for sustained drug-releasing applications[J].Nanomaterials, 2021, 11(5):1316.
[7] YANG Y F, SHI Y Y, CAO X K, et al.Preparation and functional properties of poly(vinyl alcohol)/ethyl cellulose/tea polyphenol electrospun nanofibrous films for active packaging material[J].Food Control, 2021, 130:108331.
[8] FOX P F, BRODKORB A.The casein micelle:Historical aspects, current concepts and significance[J].International Dairy Journal, 2008, 18(7):677-684.
[9] QIN J J, YANG M, WANG Y C, et al.Interaction between caffeic acid/caffeic acid phenethyl ester and micellar casein[J].Food Chemistry, 2021, 349:129154.
[10] 王楠, 杨敏, 郑杰, 等.酪蛋白胶束对原花青素稳定性的影响[J].食品与发酵工业, 2023, 49(3):164-174.
WANG N, YANG M, ZHENG J, et al.Effect of casein micelle on the stability of procyanidins[J].Food and Fermentation Industries, 2023, 49(3):164-174.
[11] DI LORENZO M L.Poly(L-lactic acid)/poly(butylene succinate) biobased biodegradable blends[J].Polymer Reviews, 2021, 61(3):457-492.
[12] ARMENTANO I, BITINIS N, FORTUNATI E, et al.Multifunctional nanostructured PLA materials for packaging and tissue engineering[J].Progress in Polymer Science, 2013, 38(10-11):1720-1747.
[13] ALTAN A, AYTAC Z, UYAR T.Carvacrol loaded electrospun fibrous films from zein and poly(lactic acid) for active food packaging[J].Food Hydrocolloids, 2018, 81:48-59.
[14] MA Y L, LI J.An antibacterial coaxial electrospun polylactic acid/silk fibroin loaded with nano-ZnO and Voltaren[J].Materials Letters, 2022, 325:132804.
[15] GHORBANI M, MAHMOODZADEH F, YAVARI MAROUFI L, et al.Electrospun tetracycline hydrochloride loaded zein/gum tragacanth/poly lactic acid nanofibers for biomedical application[J].International Journal of Biological Macromolecules, 2020, 165:1312-1322.
[16] TAN H Y, ZHANG Y H, SUN L X, et al.Preparation of nano sustained-release fertilizer using natural degradable polymer polylactic acid by coaxial electrospinning[J].International Journal of Biological Macromolecules, 2021, 193:903-914.
[17] SUN C K, ZOU L M, XU Y J, et al.Ibuprofen‐loaded poly (lactic acid) electrospun mats:The morphology, physicochemical performance, and in vitro drug release behavior[J].Macromolecular Materials and Engineering, 2020, 305(12):2000457.
[18] BIRANJE S, MADIWALE P, ADIVAREKAR R V.Porous electrospun Casein/PVA nanofibrous mat for its potential application as wound dressing material[J].Journal of Porous Materials, 2019, 26(1):29-40.
[19] KRIEGEL C, KIT K M, MCCLEMENTS D J, et al.Electrospinning of chitosan-poly(ethylene oxide) blend nanofibers in the presence of micellar surfactant solutions[J].Polymer, 2009, 50(1):189-200.
[20] NEO Y P, SWIFT S, RAY S, et al.Evaluation of Gallic acid loaded zein sub-micron electrospun fibre mats as novel active packaging materials[J].Food Chemistry, 2013, 141(3):3192-3200.
[21] LI Y, HE Z D, ZHENG Q E, et al.Hydroxypropyl-β-cyclodextrin for delivery of baicalin via inclusion complexation by supercritical fluid encapsulation[J].Molecules, 2018, 23(5):1169.
[22] 崔心想, 王艳贺, 韩立彬, 等.聚乳酸/聚酯酰胺复合纳米纤维膜制备及性能[J].工程塑料应用, 2020, 48(3):14-21.
CUI X X, WANG Y H, HAN L B, et al.Preparation and properties of polylactic acid/polyesteramide composite nanofiber film[J].Engineering Plastics Application, 2020, 48(3):14-21.
[23] HAN Y, DING J, ZHANG J T, et al.Fabrication and characterization of polylactic acid coaxial antibacterial nanofibers embedded with cinnamaldehyde/tea polyphenol with food packaging potential[J].International Journal of Biological Macromolecules, 2021, 184:739-749.
[24] GONÇALVES R P, DA SILVA F F F, PICCIANI P H S, et al.Morphology and thermal properties of core-shell PVA/PLA ultrafine fibers produced by coaxial electrospinning[J].Materials Sciences and Applications, 2015, 6(2):189-199.
[25] AYDOGDU A, YILDIZ E, AYHAN Z, et al.Nanostructured poly(lactic acid)/soy protein/HPMC films by electrospinning for potential applications in food industry[J].European Polymer Journal, 2019, 112:477-486.
[26] MIN T T, SUN X L, YUAN Z P, et al.Novel antimicrobial packaging film based on porous poly(lactic acid) nanofiber and polymeric coating for humidity-controlled release of thyme essential oil[J].LWT, 2021, 135:110034.
[27] LIU Y Y, DENG L L, ZHANG C, et al.Tunable physical properties of ethylcellulose/gelatin composite nanofibers by electrospinning[J].Journal of Agricultural and Food Chemistry, 2018, 66(8):1907-1915.
[28] LIU Y W, WANG S Y, LAN W J, et al.Fabrication of polylactic acid/carbon nanotubes/chitosan composite fibers by electrospinning for strawberry preservation[J].International Journal of Biological Macromolecules, 2019, 121:1329-1336.
[29] 王雷, 王学艳, 周雪琴, 等.黄芩苷在不同溶媒中的稳定性研究[J].中国药师, 2006, 9(2):129-131.
WANG L, WANG X Y, ZHOU X Q, et al.Study on the stability of baicalin in different solvents[J].China Pharmacist, 2006, 9(2):129-131.
[30] WANG H L, HAO L L, WANG P, et al.Release kinetics and antibacterial activity of curcumin loaded zein fibers[J].Food Hydrocolloids, 2017, 63:437-446.
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