Food and Fermentation Industries >

2024 , Vol. 50 >Issue 9: 17 - 22

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.036398

Edible yeast extract improves antioxidant levels through up regulation of Nrf-2 in skin aging model mice

  • FU Shaowei ,
  • QIN Xiuyuan ,
  • ZHANG Zhuoran ,
  • LI Mingliang ,
  • FENG Zhiyuan ,
  • LUAN Jinling ,
  • REN Wei ,
  • CHENG Qian
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  • 1(China National Research Institute of Foodand Fermentation Industries Co.Ltd., Beijing 100015, China)
    2(Beijing Engineering Research Center of Protein and Functional Peptides, Beijing 100015, China)
    3(Hubei Key Laboratory of Yeast Function, Yichang Engineering Technology Research Center of Nutrition and Health Food, Yichang 443003, China)

Received date: 2023-06-07

  Revised date: 2023-07-03

  Online published: 2024-06-11

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Abstract

Yeast extract is a natural and safe active substance that is widely used as an antioxidant in the food industry. To investigate the efficacy effect of edible yeast extract on anti-aging of skin.In this study, D-galactose was used to induce the construction of an animal model of skin aging, and different doses of yeast extract were used to intervene.Male ICR mice were randomly divided into control group (Control), model group (Model), positive group (GSH), low-dose group of yeast extract (LYE), medium-dose group of yeast extract (MYE), and high-dose group of yeast extract (HYE).Twelve animals in each group were treated for 70 consecutive days and weighed weekly.After the final gavage, the mice were fasted for 12 hours and weighed, followed by orbital blood sampling for oxidative stress indexes, and skin tissues were collected for morphological observation of skin tissues, and the expression of Nrf-2 protein in skin tissues was detected by immunoprotein blotting.The thickening of the epidermal layer of the skin tissue of mice in the experimental group of yeast extract showed significant improvement, and the serum GSH-Px enzyme activity and MDA content further increased with the increase of yeast extract dose, and the antioxidant level gradually converged to the level of the blank group, and attenuated the oxidative stress response caused by aging through up-regulation of Nrf-2 protein.This study concluded that the consumption of yeast extracts furthered the anti-aging effect mainly from the alleviation of antioxidant stress pathway, and also derived the optimal dosage with improved effects.

Key words： yeast extract; anti-aging; antioxidant; Nrf-2

Cite this article

FU Shaowei , QIN Xiuyuan , ZHANG Zhuoran , LI Mingliang , FENG Zhiyuan , LUAN Jinling , REN Wei , CHENG Qian . Edible yeast extract improves antioxidant levels through up regulation of Nrf-2 in skin aging model mice[J]. Food and Fermentation Industries, 2024 , 50(9) : 17 -22 . DOI: 10.13995/j.cnki.11-1802/ts.036398

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