Crystallization process optimization of erythritol by response surface methodology

  • GUO Yuanheng ,
  • PI dongwei ,
  • TAO jin ,
  • CAO Min ,
  • WU Lida ,
  • ZHANG Yuan ,
  • WANG Xiaoyan
Expand
  • 1(Nutrition & Health Research Institute, COFCO Corporation, Beijing 102209, China)
    2(Beijing Key Laboratory of Nutrition, Health and Food Safety, Beijing 102209, China)
    3(National Engineering Research Center of Corn Deep Processing, Jilin COFCO Biochemistry Co.Ltd., Changchun 130033, China)
    4(Wuhan COFCO Food Technology Co.Ltd., Wuhan 430415, China)

Received date: 2022-11-02

  Revised date: 2022-12-20

  Online published: 2024-06-11

Abstract

To obtain a crystallization process of erythritol, the effects of four main influencing factors (including seed addition, concentration of erythritol solution, crystallizing time and temperature) on crystallization yield of erythritol were studied.Based on the results of single factor experiments, response surface methodology was carried out to optimize crystallizing process.The results showed that the optimum operating parameters were seed addition of 1%, erythritol solution of 550 mg/mL, crystallizing time of 3 h and temperature of -4.5 ℃.Under these conditions, the erythritol crystallization yield was 52.78%.The above results indicated that the optimized model can be used to crystallize erythritol in aqueous solution.The modeled process can obtain high erythritol crystallization yield.

Cite this article

GUO Yuanheng , PI dongwei , TAO jin , CAO Min , WU Lida , ZHANG Yuan , WANG Xiaoyan . Crystallization process optimization of erythritol by response surface methodology[J]. Food and Fermentation Industries, 2024 , 50(9) : 56 -63 . DOI: 10.13995/j.cnki.11-1802/ts.034180

References

[1] BERNT W O, BORZELLECA J F, FLAMM G, et al.Erythritol:A review of biological and toxicological studies[J].Regulatory Toxicology and Pharmacology, 1996, 24(2):S191-S197.
[2] 李俊霖, 郭传庄, 王松江, 等.赤藓糖醇的特性及其应用研究进展[J].中国食品添加剂, 2019, 30(10):169-172.
LI J L, GUO C Z, WANG S J, et al.Research progress in physicochemical properties, biological activities and application of erythritol[J].China Food Additives, 2019, 30(10):169-172.
[3] MARTĂU G A, COMAN V, VODNAR D C.Recent advances in the biotechnological production of erythritol and mannitol[J].Critical Reviews in Biotechnology, 2020, 40(5):608-622.
[4] OKU T, NAKAMURA S.Digestion, absorption, fermentation, and metabolism of functional sugar substitutes and their available energy[J].Pure and Applied Chemistry, 2002, 74(7):1253-1261.
[5] 程楠, 孙晓瑜, 王晓玮, 等.赤藓糖醇龈下喷砂辅助龈下刮治及根面平整术治疗中重度慢性牙周炎的临床疗效[J].安徽医学, 2021, 42(7):731-735.
CHENG N, SUN X Y, WANG X W, et al.Subgingival erythritol powder air - polishing as an additional approach to scaling and root planning in treatment with untreated moderate to severe chronic periodontitis[J].Anhui Medical Journal, 2021, 42(7):731-735.
[6] FALONY G, HONKALA S, RUNNEL R, et al.Long-term effect of erythritol on dental caries development during childhood:A posttreatment survival analysis[J].Caries Research, 2016, 50(6):579-588.
[7] ROBERTS A C, PORTER K E.Cellular and molecular mechanisms of endothelial dysfunction in diabetes[J].Diabetes & Vascular Disease Research, 2013, 10(6):472-482.
[8] BOESTEN D M P H J, DEN HARTOG G J M, DE COCK P, et al.Health effects of erythritol[J].Nutrafoods, 2015, 14(1):3-9.
[9] BOESTEN D M P H J, BERGER A, DE COCK P, et al.Multi-targeted mechanisms underlying the endothelial protective effects of the diabetic-safe sweetener erythritol[J].PLoS One, 2013, 8(6):e65741.
[10] FLINT N, HAMBURG N M, HOLBROOK M, et al.Effects of erythritol on endothelial function in patients with type 2 diabetes mellitus:A pilot study[J].Acta Diabetologica, 2014, 51(3):513-516.
[11] ANONYMOUS.Cargill and Mitsubishi form joint venture to build erythritol plant[J].Food Technology, 1997, 51(12):10.
[12] AGUILAR F, CREBELLI R, DI DOMENICO A, et al.Scientific opinion on the safety of the proposed extension of use of erythritol (E968) as a food additive[J].EFSA J, 2015, 13(3):4033.
[13] 曹佳彦, 文静, 杨丽君, 等.“糖界贵族”赤藓糖醇的标准法规现状研究[J].质量探索, 2021, 18(1):37-40.
CAO J Y, WEN J, YANG L J, et al.Research on the status of standards and regulations of erythritol known as “sugar aristocracy”[J].Quality Exploration, 2021, 18(1):37-40.
[14] RZECHONEK D A, DOBROWOLSKI A, RYMOWICZ W, et al.Recent advances in biological production of erythritol[J].Critical Reviews in Biotechnology, 2018, 38(4):620-633.
[15] CARLY F, VANDERMIES M, TELEK S, et al.Enhancing erythritol productivity in Yarrowia lipolytica using metabolic engineering[J].Metabolic Engineering, 2017, 42:19-24.
[16] 中华人民共和国卫生部. GB 26404—2011食品安全国家标准-食品添加剂赤藓糖醇[S].北京:中国标准出版社, 2011.
Ministry of Health of the People’s Republic of China.GB 26404—2011 National standard for food safety - erythritol, a food additive[S].Beijing:China Standards Press, 2011.
[17] LU Y P, YANG Q Y, LIN Z L, et al.A modular pathway engineering strategy for the high-level production of beta-ionone in Yarrowia lipolytica[J].Microbial Cell Factories, 2020.19(1):49.
[18] 李克文. 赤藓糖醇的高效生产[D].济南:齐鲁工业大学, 2015.
LI K W.Efficient production of erythritol[D].Jinan:Qilu University of Technology, 2015.
[19] 李克文, 栾庆民, 贾慧慧, 等.一种赤藓糖醇的高收率制备方法:中国, CN110903165A[P].2020-03-24.
LI K W, LUAN Q M, JIA, H H, et al.An efficient preparation method of erythritol:China, CN110903165A[P].2020-03-24.
[20] 闫序东. 果糖结晶工艺研究[D].无锡:江南大学, 2008.
YAN X D.Technical studies on the crystallization of fructose[D].Wuxi:Jiangnan university, 2008.
[21] 李国昌, 王萍.结晶学教程[M].北京:国防工业出版社, 2008, 26-34.
LI G C, WANG P.Course of Crystallography[M].Beijing:National Defense Industry Press, 2008, 26-34.
[22] 郭元亨, 马李一, 郑华, 等.响应曲面法优化微波辅助提取胭脂虫红色素工艺[J].林产化学与工业, 2011, 31(4):87-92.
GUO Y H, MA L Y, ZHENG H, et al.Optimizing conditions for microwave-assisted extraction of cochineal dye using response surface method[J].Chemistry and Industry of Forest Products, 2011, 31(4):87-92.
[23] ZHANG L, TU Z C, WANG H, et al.Response surface optimization and physicochemical properties of polysaccharides from Nelumbo nucifera leaves[J].International Journal of Biological Macromolecules, 2015, 74:103-110.
[24] 刘鎏. 赤藓糖醇发酵和提取工艺研究[D].济南:齐鲁工业大学, 2013.
LIU L.Study on fermentation and extraction process of erythritol[D].Jinan:Qilu University of Technology, 2013.
[25] 郭元亨, 吕哲, 丁子元, 等.乙醇体系中D-阿洛酮糖的结晶工艺优化[J].食品工业科技, 2019, 40(24):185-189;198.
GUO Y H, LYU Z, DING Z Y, et al.Crystallization process optimization of D-psicose in ethanol system[J].Science and Technology of Food Industry, 2019, 40(24):185-189;198.
Outlines

/