Food and Fermentation Industries >

2024 , Vol. 50 >Issue 12: 336 - 342

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.036734

Research progress on protein synthesis based on unnatural amino acids

  • ZHAO Mei ,
  • LIU Xinyuan ,
  • CHEN Yang ,
  • SHANG Jie ,
  • CONG Hongri ,
  • MA Hao ,
  • YUVARAJ RAVIKUMAR ,
  • QI Xianghui
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  • (School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China)

Received date: 2023-07-11

  Revised date: 2023-08-08

  Online published: 2024-07-11

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Abstract

Protein is an important component of living organisms and participates in almost all life activities.Under normal circumstances, the protein in the organism is composed of 20 natural amino acids.However, with the rapid development of modern science and technology, the demand for medical treatment, food, materials, and other aspects of people’s life is increasing, and these proteins can no longer meet the diversified application needs.At the same time, with the excellent performance of unnatural amino acids and their synthesized proteins are gradually becoming a research hot spot.The technology of modifying proteins with unnatural amino acids has been gradually developed.Unnatural amino acids have different side chain groups from natural amino acids, which can bring new properties and functions to proteins.Based on the study of unnatural amino acids and unnatural proteins, this review first introduces the chemical and biological methods for synthesizing unnatural amino acids, and summarizes the advantages and disadvantages of chemical and biological methods and their future development prospects.Then several popular methods of incorporating unnatural amino acids into proteins are presented.Then, the applications of unnatural amino acids and their synthetic proteins in enzyme modification, scientific research and medical treatment are listed and described.Finally, the future development of this technology is prospected and summarized.

Key words： unnatural amino acids; unnatural proteins; cell metabolic engineering; genetic code expansion; enzyme modification; protein drug modification

Cite this article

ZHAO Mei , LIU Xinyuan , CHEN Yang , SHANG Jie , CONG Hongri , MA Hao , YUVARAJ RAVIKUMAR , QI Xianghui . Research progress on protein synthesis based on unnatural amino acids[J]. Food and Fermentation Industries, 2024 , 50(12) : 336 -342 . DOI: 10.13995/j.cnki.11-1802/ts.036734

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