This study aimed to explore the anti-aging ability of carrageenan oligosaccharides based on the biobeauty Caenorhabditis elegans model.Nematodes were fed with Escherichia coli solution containing different concentrations (0, 0.25, 0.50, 1.00 mg/mL) of carrageenan oligosaccharides.The study observed the effects of carrageenan oligosaccharides on nematode longevity, fecundity, body length, body width, lipofuscin, exercise capacity, and heat stress capacity and measured the reactive oxygen species (ROS) content and antioxidant enzyme activity in nematodes, investigating the effect of carrageenan oligosaccharides on anti-aging in nematodes.Compared with the control group, all concentrations of carrageenan oligosaccharide (KCO-5) with a molecular weight of 1.58 kDa could prolong the lifespan of nematodes and could extend the lifespan of nematodes by 4.18%-16.48%.It improved the body length, width, locomotion and stress capacity of nematodes, reduced the level of lipofuscin accumulation in the body, and did not impair reproductive ability.KCO-5 significantly reduced the content of ROS and malondialdehyde in nematodes and increased the activities of superoxide dismutase, catalase, and glutathione in a dose-dependent manner (P<0.05).Results showed that KCO-5 neutralized the excess ROS, enhanced the stress resistance of nematodes, and extended the lifespan.In summary, carrageenan oligosaccharides have anti-aging benefits and are a new possible source of functional food or drug alternatives for reducing oxidative stress and improving a healthy lifespan.
LI Ziyu
,
SONG Bingbing
,
PAN Mingxue
,
YUAN Yuan
,
CHEN Jing
,
WANG Zhuo
,
CHEONG Kit-leong
,
ZHONG Saiyi
. Anti-aging effect of carrageenan oligosaccharides on Caenorhabditis elegans[J]. Food and Fermentation Industries, 2024
, 50(13)
: 39
-46
.
DOI: 10.13995/j.cnki.11-1802/ts.038750
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