Food and Fermentation Industries >

2024 , Vol. 50 >Issue 16: 271 - 277

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.037422

Effects of Perilla seed oil on intestinal microorganisms and antioxidant capacity in mice

  • CHEN Xuemei ,
  • HU Bo ,
  • TANG Xiaoshu ,
  • ZHANG Baixi
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  • 1(National Engineering Research Center for Function Food, Jiangnan University, Wuxi 214122, China)
    2(Food Science and Technology, Jiangnan University, Wuxi 214122, China)

Received date: 2023-09-19

  Revised date: 2023-10-10

  Online published: 2024-09-19

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Abstract

Perilla seed oil contains rich and active ingredients such as α-linolenic acid, tocopherols, phytosterols, and polyphenols.Studying the effects of Perilla seed oil on the antioxidant activity and intestinal microorganisms can deliver valuable information for its development and application.Fifty KM male mice were randomly divided into 5 groups, including blank group, model group, and Perilla seed oil groups.The Perilla seed oil groups consisted of low dose group (1.25 mL/kg BW), medium dose group (2.5 mL/kg BW), and high dose group (5 mL/kg BW).The feces of the blank group and Perilla seed oil groups were collected for intestinal microflora sequencing after intervention for 30 days.The effects of Perilla seed oil on the intestinal microorganisms of mice were studied by detecting microbial diversity, species abundance, and differential changes in different mice groups.An ethanol oxidative damage model was established, and the effects of Perilla seed oil on the antioxidant capacity of mice were evaluated by measuring the growth performance indexes and the contents of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), and protein carbonyl (PCO).Compared with the blank group, the results showed that the amount of fecal microbiota of the Perilla seed oil mice group increased, and the species changed significantly, indicating that Perilla seed oil had effects of weight loss and antioxidant stress.Compared with the ethanol oxidative damage model group, the PCO and MDA were significantly reduced in Perilla seed oil mice group, the SOD was significantly increased in the medium and high dose Perilla seed oil mice groups, GSH was increased, the mice weight was significantly reduced, and the visceral-body ratio of heart and kidney were improved in high dose Perilla seed oil mice group.In conclusion, Perilla seed oil can regulate the intestinal flora of mice, improve anti-oxidation capacity, and slightly enhance the weight loss efficiency.

Key words： Perilla seed oil; growth performance of mice; oxidative damage model of ethanol; antioxidant capacity; microbial diversity

Cite this article

CHEN Xuemei , HU Bo , TANG Xiaoshu , ZHANG Baixi . Effects of Perilla seed oil on intestinal microorganisms and antioxidant capacity in mice[J]. Food and Fermentation Industries, 2024 , 50(16) : 271 -277 . DOI: 10.13995/j.cnki.11-1802/ts.037422

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