[1] 陈敬敬, 韩金花, 张永胜, 等.肉制品中杂环胺的研究进展[J].中国食品卫生杂志, 2022, 34(1):168-174.
CHEN J J, HAN J H, ZHANG Y S, et al.Research progress of heterocyclic amines in meat products[J].Chinese Journal of Food Hygiene, 2022, 34(1):168-174.
[2] SHEN X, CHEN Y, OJOBI OMEDI J, et al.Effects of volatile organic compounds of smoke from different woods on the heterocyclic amine formation and quality changes in pork patty[J].Food Research International, 2023, 173(Pt 1):113262.
[3] 王惠汀, 孙学颖, 王丹, 等.肉制品中杂环胺类化合物形成及控制措施的研究进展[J].食品研究与开发, 2022, 43(5):195-203.
WANG H T, SUN X Y, WANG D, et al.Research progress of formation and control measures of heterocyclic aromatic amines in meat products[J].Food Research and Development, 2022, 43(5):195-203.
[4] XUE T, JIANG Q Q, XIANG L W, et al.Effect of chemical modification of κ-carrageenan on its inhibitory effect against heterocyclic amine (HAs) formation in roasted tilapia fish patties[J].International Journal of Biological Macromolecules, 2023, 253(Pt 1):126586.
[5] 郝麒麟, 黄先智, 丁晓雯.食品中杂环胺的危害与控制措施研究进展[J].食品与发酵工业, 2019, 45(13):275-280.
HAO Q L, HUANG X Z, DING X W.Threat of heterocyclic amines in foods and their controlling measures[J].Food and Fermentation Industries, 2019, 45(13):275-280.
[6] 洪燕婷, 王盼, 朱雨辰, 等.肉制品中杂环胺形成与控制的研究进展[J].中国食品学报, 2014, 14(11):149-156.
HONG Y T, WANG P, ZHU Y C, et al.Development in controlling and formation of heterocyclic amines in meat[J].Journal of Chinese Institute of Food Science and Technology, 2014, 14(11):149-156.
[7] 赵东霞, 李丹慧, 隋明航, 等.用分子形貌理论探讨杂环化合物的键长、极化率和芳香性[J].中国科学:化学, 2016, 46(1):101-113; 1-6.
ZHAO D X, LI D H, SUI M H, et al.Molecular face theory being applied to investigate the bond length, polarizability and aromaticity in the heterocyclic compounds[J].Scientia Sinica Chimica, 2016, 46(1):101-113; 1-6.
[8] BELLAMRI M, WALMSLEY S J, TURESKY R J.Metabolism and biomarkers of heterocyclic aromatic amines in humans[J].Genes and Environment, 2021, 43(1):29.
[9] RIZWAN KHAN M, NAUSHAD M, ABDULLAH ALOTHMAN Z.Presence of heterocyclic amine carcinogens in home-cooked and fast-food camel meat burgers commonly consumed in Saudi Arabia[J].Scientific Reports, 2017, 7(1):1707.
[10] 丁晓倩.多酚对羊肉炭烤过程杂环胺形成的抑制作用[D].北京:中国农业科学院,2021.
DING X Q. Inhibitory effect of polyphenols on heterocyclic amines formation during mutton char roasting[D]. Beijing:Chinese Academy of Agricultural Sciences,2021.
[11] 张彪. 食品中生物胺与杂环胺高通量荧光免疫检测方法研究[D].天津:天津科技大学,2023.
ZHANG B. Study on high-throughput fluorescence immunoassay for biogenic amines and heterocyclic amines in food[D]. Tianjin: Tianjin University of Science and Technology,2023.
[12] 于小慧. 焙烤花生中糖基化终产物和杂环胺的形成与控制[D].郑州:河南工业大学,2022.
YU X H. Formation and control of glycosylation end products and heterocyclic amines in roasted peanuts[D]. Zhengzhou: Henan University of Technology,2022.
[13] 张晨霞, 盛冰莹, 张咪, 等.不同产地芝麻所制芝麻油中杂环胺的分析测定[J].中国油脂, 2023, 48(4):87-93.
ZHANG C X, SHENG B Y, ZHANG M, et al.Determination and analysis of heterocyclic aromatic amines in sesame oil extracted from sesame of different producing areas[J].China Oils and Fats, 2023, 48(4):87-93.
[14] 邓鹏,胡璐曼,凌菁,等.煎香肠中杂环胺的生成规律研究[J].食品安全质量检测学报, 2022, 13 (11): 3423-3430.
DENG P, HU L M, LING J, et al. Study on the formation of heterocyclic amines in fried sausage[J]. Journal of Food Safety and Quality Inspection,2022,13(11):3423-3430.
[15] 李梦, 林松毅, 王睿纯, 等.山药提取物对烤马友鱼中杂环胺的抑制作用[J].中国食品学报, 2023, 23(1):194-203.
LI M, LIN S Y, WANG R C, et al.Inhibitory effect of yam extract on heterocyclic amines in roasted Eleutheronema tetradactylum[J].Journal of Chinese Institute of Food Science and Technology, 2023, 23(1):194-203.
[16] 王可心, 王华丽, 单艳琴, 等.生姜对烘烤猪肉饼品质及杂环胺形成的影响[J].食品研究与开发, 2023, 44(5):9-14.
WANG K X, WANG H L, SHAN Y Q, et al.Effects of ginger on the quality of roasted pork patties and the formation of heterocyclic aromatic amines[J].Food Research and Development, 2023, 44(5):9-14.
[17] 叶惠萍, 曾晓房, 白卫东, 等.红烧乳鸽中11种极性杂环胺的UHPLC-Q-Orbitrap HRMS检测[J].轻工学报, 2023, 38(2):56-62.
YE H P, ZENG X F, BAI W D, et al.Determination of 11 polar heterocyclic aromatic amines in braised squab By UHPLC-Q-Orbitrap HRMS[J].Journal of Light Industry, 2023, 38(2):56-62.
[18] ALI KHAN I, SHI B P, SHI H B, et al.Attenuation of heterocyclic amine formation and lipid and protein oxidation in air-fried fish fillets by marination with selected legume seed extracts[J].Food Chemistry, 2024, 435:137592.
[19] 薛桂中, 黄现青, 宋莲军, 等.高温肉制品杂环胺防控及体内代谢调控研究进展[J].食品科学, 2022, 43(13):256-266.
XUE G Z, HUANG X Q, SONG L J, et al.Progress in the prevention of the formation of heterocyclic amines in high-temperature meat products and the regulation of their metabolism in the human body[J].Food Science, 2022, 43(13):256-266.
[20] SCHUT H A, SNYDERWINE E G.DNA adducts of heterocyclic amine food mutagens:Implications for mutagenesis and carcinogenesis[J].Carcinogenesis, 1999, 20(3):353-368.
[21] TURESKY R J, LE MARCHAND L.Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies:Lessons learned from aromatic amines[J].Chemical Research in Toxicology, 2011, 24(8):1169-1214.
[22] KODA M, IWASAKI M, YAMANO Y, et al.Association between NAT2, CYP1A1, and CYP1A2 genotypes, heterocyclic aromatic amines, and prostate cancer risk:A case control study in Japan[J].Environmental Health and Preventive Medicine, 2017, 22(1):72.
[23] BOOBIS A R, LYNCH A M, MURRAY S, et al.CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans[J].Cancer Research, 1994, 54(1):89-94.
[24] LANGOUËT S, WELTI D H, KERRIGUY N, et al.Metabolism of 2-amino-3, 8-dimethylimidazo[4, 5-f]quinoxaline in human hepatocytes:2-amino-3-methylimidazo[4, 5-f]quinoxaline-8-carboxylic acid is a major detoxification pathway catalyzed by cytochrome P450 1A2[J].Chemical Research in Toxicology, 2001, 14(2):211-221.
[25] OLALEKAN ADEYEYE S A, ASHAOLU T J.Heterocyclic amine formation and mitigation in processed meat and meat products:A mini-review[J].Journal of Food Protection, 2021, 84(11):1868-1877.
[26] TURESKY R J, CONSTABLE A, RICHOZ J, et al.Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2[J].Chemical Research in Toxicology, 1998, 11(8):925-936.
[27] AIROLDI L, MAGAGNOTTI C, PASTORELLI R, et al.Enzyme polymorphisms influencing the metabolism of heterocyclic aromatic amines[J].Journal of Chromatography.B, Analytical Technologies in the Biomedical and Life Sciences, 2004, 802(1):175-181.
[28] HEIN D W.Molecular genetics and function of NAT1 and NAT2:Role in aromatic amine metabolism and carcinogenesis[J].Mutation Research, 2002, 506-507:65-77.
[29] YUAN Z X, JHA G, MCGREGOR M A, et al.Metabolites of the carcinogen 2-amino-alpha-carboline formed in male Sprague-Dawley rats in vivo and in rat hepatocyte and human HepG2 cell incubates[J].Chemical Research in Toxicology, 2007, 20(3):497-503.
[30] BELLAMRI M, LE HEGARAT L, TURESKY R J, et al.Metabolism of the tobacco carcinogen 2-amino-9H-pyrido[2, 3-b]indole (AαC) in primary human hepatocytes[J].Chemical Research in Toxicology, 2017, 30(2):657-668.
[31] TURESKY R J, GARNER R C, WELTI D H, et al.Metabolism of the food-borne mutagen 2-amino-3, 8-dimethylimidazo[4, 5-f]quinoxaline in humans[J].Chemical Research in Toxicology, 1998, 11(3):217-225.
[32] TANG Y J, LEMASTER D M, NAUWELAËRS G, et al.UDP-glucuronosyltransferase-mediated metabolic activation of the tobacco carcinogen 2-amino-9H-pyrido[2, 3-b]indole[J].The Journal of Biological Chemistry, 2012, 287(18):14960-14972.
[33] 付瑜锋, 胡少东, 段鹍, 等.主要杂环胺类化合物研究进展[J].轻工学报, 2018, 33(1):13-25.
FU Y F, HU S D, DUAN K, et al.Research progress of the major HAAs[J].Journal of Light Industry, 2018, 33(1):13-25.
[34] 王守涛. 亚临界乙醇/水提取木瓜原花青素及其对油炸鸡肉中杂环胺的抑制作用[D].郑州:河南工业大学,2022.
WANG S T.Extraction of papaya proanthocyanidins by subcritical ethanol/water and its inhibitory effect on heterocyclic amines in fried chicken[D].Zhengzhou:Henan University of Technology,2022.
[35] NADEEM H R, AKHTAR S, ISMAIL T, et al.Heterocyclic aromatic amines in meat:Formation, isolation, risk assessment, and inhibitory effect of plant extracts[J].Foods, 2021, 10(7):1466.
[36] TOTSUKA Y, WAKABAYASHI K.Biological significance of aminophenyl-β-carboline derivatives formed from co-mutagenic action of β-carbolines and aniline and o-toluidine and its effect on tumorigenesis in humans:A review[J].Mutation Research.Genetic Toxicology and Environmental Mutagenesis, 2020, 850-851:503148.
[37] 王一然, 刘磊.某些富含蛋白质烹调食品中致突变物形成的研究[J].哈尔滨医科大学学报, 2011, 45(5):427-430.
WANG Y R, LIU L.Study on the forming of mutagen in some protein-rich cooking food[J].Journal of Harbin Medical University, 2011, 45(5):427-430.
[38] LYNCH A M, GOODERHAM N J, BOOBIS A R.Organ distinctive mutagenicity in MutaMouse after short-term exposure to PhIP[J].Mutagenesis, 1996, 11(5):505-509.
[39] GI M, FUJIOKA M, TOTSUKA Y, et al.Quantitative analysis of mutagenicity and carcinogenicity of 2-amino-3-methylimidazo[4, 5-f]quinoline in F344 gpt delta transgenic rats[J].Mutagenesis, 2019, 34(3):279-287.
[40] BULANDA S, JANOSZKA B.Consumption of thermally processed meat containing carcinogenic compounds (polycyclic aromatic hydrocarbons and heterocyclic aromatic amines) versus a risk of some cancers in humans and the possibility of reducing their formation by natural food additives: A literature review[J].International Journal of Environmental Research and Public Health, 2022, 19(8):4781.
[41] 郑蒙, 林雪, 谢华兵, 等.杂环胺摄入与结直肠癌关系的剂量-反应meta分析[J].胃肠病学, 2020, 25(6):348-357.
ZHENG M, LIN X, XIE H B, et al.Association between heterocyclic amines intake and colorectal cancer:A dose-response meta-analysis[J].Chinese Journal of Gastroenterology, 2020, 25(6):348-357.
[42] MARTÍNEZ GÓNGORA V, MATTHES K L, CASTAÑO P R, et al.Dietary heterocyclic amine intake and colorectal adenoma risk:A systematic review and meta-analysis[J].Cancer Epidemiology, Biomarkers & Prevention:a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2019, 28(1):99-109.
[43] TORRE L A, BRAY F, SIEGEL R L, et al.Global cancer statistics, 2012[J].CA:A Cancer Journal for Clinicians, 2015, 65(2):87-108.
[44] CROSS A J, FREEDMAN N D, REN J S, et al.Meat consumption and risk of esophageal and gastric cancer in a large prospective study[J].The American Journal of Gastroenterology, 2011, 106(3):432-442.
[45] SANDER A, LINSEISEN J, ROHRMANN S.Intake of heterocyclic aromatic amines and the risk of prostate cancer in the EPIC-Heidelberg cohort[J].Cancer Causes & Control:CCC, 2011, 22(1):109-114.
[46] BOGEN K T, KEATING G A 2nd, CHAN J M, et al.Highly elevated PSA and dietary PhIP intake in a prospective clinic-based study among African Americans[J].Prostate Cancer and Prostatic Diseases, 2007, 10(3):261-269.
[47] FELTON J S, KNIZE M G, SALMON C P, et al.Human exposure to heterocyclic amine food mutagens/carcinogens:Relevance to breast cancer[J].Environmental and Molecular Mutagenesis, 2002, 39(2-3):112-118.
[48] ZHENG W, LEE S A.Well-done meat intake, heterocyclic amine exposure, and cancer risk[J].Nutrition and Cancer, 2009, 61(4):437-446.
[49] SYEDA T, CANNON J R.Potential role of heterocyclic aromatic amines in neurodegeneration[J].Chemical Research in Toxicology, 2022, 35(1):59-72.
[50] AGIM Z S, CANNON J R.Dietary factors in the etiology of Parkinson’s disease[J].BioMed Research International, 2015, 2015:672838.
[51] PERRONE L, GRANT W B.Observational and ecological studies of dietary advanced glycation end products in national diets and Alzheimer’s disease incidence and prevalence[J].Journal of Alzheimer’s Disease:JAD, 2015, 45(3):965-979.
[52] LAWANA V, UM S Y, ROCHET J C, et al.Neuromelanin modulates heterocyclic aromatic amine-induced dopaminergic neurotoxicity[J].Toxicological Sciences: An Official Journal of the Society of Toxicology, 2020, 173(1):171-188.
[53] AGIM Z S, CANNON J R.Alterations in the nigrostriatal dopamine system after acute systemic PhIP exposure[J].Toxicology Letters, 2018, 287:31-41.
[54] SYEDA T, FOGUTH R M, LLEWELLYN E, et al.PhIP exposure in rodents produces neuropathology potentially relevant to Alzheimer’s disease[J].Toxicology, 2020, 437:152436.
[55] SAMMI S R, AGIM Z S, CANNON J R.From the cover:Harmane-induced selective dopaminergic neurotoxicity in Caenorhabditis elegans[J].Toxicological Sciences: An Official Journal of the Society of Toxicology, 2018, 161(2):335-348.
[56] LOUIS E D, MICHALEC M, JIANG W, et al.Elevated blood harmane (1-methyl-9H-pyrido[3, 4-b]indole) concentrations in Parkinson’s disease[J].Neurotoxicology, 2014, 40:52-56.
[57] LOUIS E D, ZHENG W, JUREWICZ E C, et al.Elevation of blood beta-carboline alkaloids in essential tremor[J].Neurology, 2002, 59(12):1940-1944.
[58] LOUIS E D, FACTOR-LITVAK P, LIU X H, et al.Elevated brain harmane (1-methyl-9H-pyrido[3, 4-b]indole) in essential tremor cases vs.controls[J].Neurotoxicology, 2013, 38:131-135.
[59] GRIGGS A M, AGIM Z S, MISHRA V R, et al.2-Amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP) is selectively toxic to primary dopaminergic neurons in vitro[J].Toxicological Sciences: An Official Journal of the Society of Toxicology, 2014, 140(1):179-189.
[60] CRUZ-HERNANDEZ A, AGIM Z S, MONTENEGRO P C, et al.Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons[J].Neurotoxicology, 2018, 65:68-84.
[61] SUGIMURA T.Food and cancer[J].Toxicology, 2002, 181-182:17-21.
[62] DAVIS C D, FARB A, THORGEIRSSON S S, et al.Cardiotoxicity of heterocyclic amine food mutagens in cultured myocytes and in rats[J].Toxicology and Applied Pharmacology, 1994, 124(2):201-211.
[63] DAVIS C D, SNYDERWINE E G.Protective effect of N-acetylcysteine against heterocyclic amine-induced cardiotoxicity in cultured myocytes and in rats[J].Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 1995, 33(8):641-651.
[64] CHEN X Q, JIA W, ZHU L, et al.Recent advances in heterocyclic aromatic amines:An update on food safety and hazardous control from food processing to dietary intake[J].Comprehensive Reviews in Food Science and Food Safety, 2020, 19(1):124-148.
[65] YANG D D, HE Z Y, GAO D M, et al.Effects of smoking or baking procedures during sausage processing on the formation of heterocyclic amines measured using UPLC-MS/MS[J].Food Chemistry, 2019, 276:195-201.
[66] MILLER A J, BUCHANAN R L.Detection of genotoxicity in fried bacon by the Salmonella/mammalian microsome mutagenicity assay[J].Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 1983, 21(3):319-323.
[67] FELTON J S, FULTZ E, DOLBEARE F A, et al.Effect of microwave pretreatment on heterocyclic aromatic amine mutagens/carcinogens in fried beef patties[J].Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 1994, 32(10):897-903.
[68] BARZEGAR F, KAMANKESH M, MOHAMMADI A.Heterocyclic aromatic amines in cooked food:A review on formation, health risk-toxicology and their analytical techniques[J].Food Chemistry, 2019, 280:240-254.
[69] 杨钊宇,刘伟,李耘.油炸鸡肉中杂环胺的形成及其与色泽的相关性研究[J].河南工业大学学报(自然科学版),2021,42(5):55-63.
YANG Z Y, LIU W, LI Y. Study on the formation of heterocyclic amines in fried chicken and their correlation with color[J]. Journal of Henan University of Technology (Natural Science Edition),2021,42(5):55-63.
[70] ZHAO L L, WEI J Y, ZHAO H F, et al.Detoxification of cancerogenic compounds by lactic acid bacteria strains[J].Critical Reviews in Food Science and Nutrition, 2018, 58(16):2727-2742.
[71] 王惠汀, 刘培清, 晓燕, 等.高吸附杂环胺乳酸菌的筛选、吸附特性及机理研究[J].中国食品学报, 2023, 23(6):41-47.
WANG H T, LIU P Q, XIAO Y, et al.Screening, adsorption characteristics and mechanism of lactic acid bacteriawith high heterocyclic aromatic amines adsorption capacity[J].Journal of Chinese Institute of Food Science and Technology, 2023, 23(6):41-47.
[72] JINAP S, IQBAL S Z, SELVAM R M P.Effect of selected local spices marinades on the reduction ofheterocyclic amines in grilled beef (satay)[J].LWT - Food Science and Technology, 2015, 63(2):919-926.
[73] 张漫漫. 山黑猪叉烧肉工艺配方优化及产品加工中杂环胺抑制研究[D].长春:吉林大学, 2023.
ZHANG M M.Study on optimization of Shanhei pork barbecued meat process formula and inhibition of heterocyclic amines in product processing[D].Changchun:Jilin University, 2023.
[74] 华玲, 王杰.黑胡椒对烤草鱼中杂环胺含量和品质的影响[J].中国调味品, 2023, 48(4):80-84.
HUA L, WANG J.Effect of black pepper on heterocyclic aromatic amine content and quality of grilled grass carp[J].China Condiment, 2023, 48(4):80-84.
[75] 李星雨, 徐筱莹, 雷秋琪, 等.香辛料提取物及其主效成分对煎制猪肉中杂环胺生成的影响[J].中国调味品, 2022, 47(3):21-27.
LI X Y, XU X Y, LEI Q Q, et al.Effect of spice extract and its main components on the production of heterocyclic amines in fried pork[J].China Condiment, 2022, 47(3):21-27.
[76] 张世钰, 高萌, 王未, 等.植物多酚抑制热加工肉制品中杂环胺形成机制研究进展[J].食品科学, 2023, 44(9):211-220.
ZHANG S Y, GAO M, WANG W, et al.Research progress on the inhibitory mechanism of plant polyphenols on the formation of heterocyclic amines in thermally processed meat products[J].Food Science, 2023, 44(9):211-220.
[77] DING X Q, ZHANG D Q, LIU H, et al.Chlorogenic acid and Epicatechin:An efficient inhibitor of heterocyclic amines in charcoal roasted lamb meats[J].Food Chemistry, 2022, 368:130865.
[78] 杨爍, 李佳珊, 尚宏丽.绿茶提取物对炸羊肉丸中杂环胺形成的抑制作用[J].食品工业, 2023, 44(9):123-127.
YANG S, LI J S, SHANG H L.Inhibition of heterocyclic amine formation in fried lamb balls in green tea extract[J].The Food Industry, 2023, 44(9):123-127.
[79] 孔婉青. 光皮木瓜原花青素的解聚及其产物对煎炸食物中杂环胺的抑制研究[D].郑州:河南工业大学,2023.
KONG W Q.Depolymerization of proanthocyanidins from papaya and their inhibition of heterocyclic amines in fried food[D].Zhengzhou:Henan University of Technology,2023.
[80] 周娜, 张会敏, 潘飞, 等.矢车菊-3-O-葡萄糖苷及其代谢物原儿茶酸对杂环胺诱导细胞损伤的修复机制[J].食品科学, 2022, 43(15):141-149.
ZHOU N, ZHANG H M, PAN F, et al.Mechanism by which cyanidin-3-O-glucoside and its metabolite protocatechuic acid repair heterocyclic aromatic amines-induced cell damage[J].Food Science, 2022, 43(15):141-149.
[81] XU Y, HUANG T R, HUANG Y Q, et al.Effect of mulberry leaf (Morus alba L.) extract on the quality and formation of heterocyclic amines in braised Muscovy duck[J].Food Control, 2024, 156:110137.
