Obesity seriously affects human health, it is urgent to develop a safe and healthy food to treat hyperlipidemia adjuvant without side effects.In this paper, the lipid lowering effect and mechanism of kiwi fruit powder were studied in vivo.The aim is to provide theoretical basis for kiwi fruit powder to assist the treatment of hyperlipidemia and realize its high value-added utilization.The mice were randomly divided into 5 groups:high-fat diet group (MD), low-dose and high-dose kiwi fruit powder gavage group (LFP and HFP), positive control group (simvastatin BK) and normal diet blank group (PC).After feeding for 13 weeks, the body weight and organ index of different groups of mice were compared.Glucose tolerance, serum biochemical indexes, liver biochemical indexes, and the contents of leptin and inflammatory factors in vivo were measured.The liver sections of mice were observed by hematoxylin-eosin staining and oil red O staining.The effect of kiwi fruit powder on lipid lowering and its mechanism were studied.The results showed that all indexes of high-fat diet group were abnormal, and there were significant differences compared with other groups (P<0.05).Compared with MD group, all indexes of mice were improved after administration of kiwi fruit powder, and the dose-effect relationship was obvious.There were no significant differences in liver index, total cholesterol, low density lipoprotein cholesterol, alanine aminotransferase, aspartate transaminase and leptin compared with PC group (P>0.05).The liver cell structure of mice in HFP group was clear.There was no obvious deformation, no obvious expansion of hepatic sinuses, and the lipid droplets basically disappeared.The results indicated that kiwi fruit powder could reduce weight and lipid, regulate lipid metabolism and reduce liver injury.
CAI Luyang
,
WANG Ketang
,
CHEN Xuefeng
,
CHEN Mengyin
,
ZHAO Yanni
,
FU Huan
,
LI Yongning
. Study on the lipid-lowering effect of kiwi fruit powder[J]. Food and Fermentation Industries, 2024
, 50(21)
: 287
-293
.
DOI: 10.13995/j.cnki.11-1802/ts.036865
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