Food and Fermentation Industries >

2025 , Vol. 51 >Issue 1: 381 - 389

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.040890

Advancements in antibiotic resistance regulation by two-component regulatory systems in Gram-negative bacteria

  • LIU Huan ,
  • LIU Chang ,
  • LEI Huayu ,
  • CAO Juanjuan ,
  • WANG Yingying ,
  • ZHAO Yanni
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  • 1(School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi’an 710021, China)
    2(Shaanxi Research Institute of Agricultural Products Processing Technology, Xi’an 710021, China)

Received date: 2024-08-29

  Revised date: 2024-09-23

  Online published: 2025-01-23

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Abstract

The abuse of antibiotics has precipitated a persistent escalation in bacterial drug resistance and the detection rate of multidrug-resistant Gram-negative bacteria has been climbing, representing a grave threat to public health and engendering considerable risks within the realms of food production and processing.Two-component regulatory systems (TCSs) are widely present in the Gram-negative bacteria, consisting of the histidine kinase (HK) that senses signals and the corresponding response regulator protein (RR).It is an important signal transduction system in bacteria, widely involved in different physiological processes of bacteria, and plays pivotal roles in bacterial drug resistance.Hence, the intervention therapy targeting at TCSs is deemed a highly promising approach to overcome antibiotic resistance.This review elucidates the involvement of TCSs in orchestrating diverse mechanisms of antibiotic resistance, encompassing the regulation of antibiotic inactivating enzyme synthesis, alterations to the cell surface, modulation of drug influx and efflux, and other regulatory pathways.It underscores the advancements in our understanding of the regulatory functions in antibiotic resistance of TCSs in Gram-negative bacteria, with the objective of furnishing theoretical insights and references for the prevention and control of antibiotic-resistant food pathogens.

Key words： two-component regulatory systems; Gram-negative bacteria; resistance; antibiotics; mechanism

Cite this article

LIU Huan , LIU Chang , LEI Huayu , CAO Juanjuan , WANG Yingying , ZHAO Yanni . Advancements in antibiotic resistance regulation by two-component regulatory systems in Gram-negative bacteria[J]. Food and Fermentation Industries, 2025 , 51(1) : 381 -389 . DOI: 10.13995/j.cnki.11-1802/ts.040890

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