Clinical drug treatment for hyperuricemia (HUA) has significant side effects.Probiotics, as natural and safe food supplements, can assist in treating HUA.This study aimed to explore the mechanisms by which probiotics alleviate HUA and provide kidney protection.Lactobacillus gasseri CCFM1346 (5×109 CFU/g) was administered to HUA model mice via oral gavage for 3 weeks.Physiological and biochemical parameters of mice, kidney histopathological sections, liver xanthine oxidase (XOD), and uricase (UOX) activities, as well as expression levels of kidney uric acid transporters, inflammasomes, and inflammatory factors, were examined.Results showed that both live and dead cells of L. gasseri CCFM1346 significantly decreased the serum uric acid levels in mice, inhibited liver XOD activity, and promoted liver UOX activity (P<0.01).Both live and dead cells significantly increased uric acid levels in the urine of HUA mice, downregulated expression of kidney reabsorption transporters, and upregulated expression of excretion transporters (P<0.001).Both live and dead cells reduced mRNA expression of NLRP3, ASC, and Caspase-1, and inflammatory factors TNF-α, IL-6, and IL-1β in kidney (P<0.01).L.gasseri CCFM1346 alleviates HUA by regulating uric acid metabolism and improving kidney inflammation.
ZHANG Shuling
,
TANG Xin
,
MAO Bingyong
,
ZHANG Qiuxiang
,
ZHAO Jianxin
,
CHEN Wei
,
CUI Shumao
. Lactobacillus gasseri CCFM1346 alleviates hyperuricemia in mice by regulating uric acid metabolism and improving kidney inflammation[J]. Food and Fermentation Industries, 2025
, 51(3)
: 52
-57
.
DOI: 10.13995/j.cnki.11-1802/ts.038962
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