This study aimed to develop a healthy food product that meets the dietary requirements of type 2 diabetes, aiming to decrease blood glucose levels and mitigate associated complications.According to the “Dietary Guidelines for Chinese Residents 2022”, “Guidelines for Medical Nutritional Therapy of Diabetes Mellitus in China 2022”, and other documents, a healthy food, meal replacement powder, that can meet the nutritional needs of type 2 diabetes patients was prepared by reasonably adjusting the proportion of dietary nutrients and adding a variety of food raw materials with low-glycemic index (GI) and raw materials with homology of medicine and food.The main nutrient content of the product was tested according to the methods specified in the national standard.A high-fat diet combined with streptozotocin induction was used to establish a mouse model of type 2 diabetes to confirm the beneficial effects of meal replacement powder on diabetes.The meal replacement powder formula was based on skimmed milk powder as the main ingredient and added a variety of raw materials with a homology of medicine and food (yam powder, Pueraria Mirifica powder, coix seed powder, and mulberry leaf powder).In animal experiments, meal replacement powder could improve the symptoms of polydipsia and weight loss in mice with type 2 diabetes.In the meal replacement group, fasting blood glucose was decreased, blood glucose tolerance was enhanced, insulin resistance was decreased, and high-density lipoprotein cholesterol (HDL-C) was increased.Meal replacement powder also decreased alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in type 2 diabetic mice, while triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels were reduced.Moreover, the pathological changes of the liver, kidney, and islet in type 2 diabetic mice were improved in the meal replacement powder group.By referring to the actual nutritional requirements of diabetes patients and various related standards, a healthy food with balanced nutrition and the capacity to control blood sugar was produced.
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