Research progress in biological characteristics of Smac and its regulating IAPs to promote apoptosis

  • WANG Jingyu ,
  • HU Tieying ,
  • CHEN Cheng ,
  • ZHANG Li ,
  • ZHANG Yubin ,
  • MA Guoyuan ,
  • LI Aixia ,
  • SHI Xixiong
Expand
  • (College of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730070, China)

Received date: 2024-08-13

  Revised date: 2024-09-19

  Online published: 2025-06-11

Abstract

The second mitochondria-derived activator of caspase (Smac) is a pro-apoptotic protein released from mitochondria, which is located in the mitochondrial membrane gap.Studies have found that the mitochondrial localization signal peptide of Smac is removed, and Smac will be released from mitochondria into the cytoplasm.It can competitively bind to inhibitors of apoptosis proteins (IAPs) or promote the ubiquitination-degradation of IAPs, inhibit the expression of IAPs, and relieve the inhibition of IAPs on caspase, thereby inducing the occurrence of apoptosis cascade.This paper summarizes and reviews the biological characteristics of Smac, the ways of Smac regulating IAPs to promote apoptosis, and the research progress of Smac regulating IAPs to promote apoptosis of tumor cells, T cells, and muscle cells.The future research direction of Smac regulating IAPs to promote apoptosis of tumor cells, T cells and muscle cells is prospected, which can provide new insights for targeted therapy of tumors and the theory of muscle tenderization.

Key words: Smac; IAPs; caspase; apoptosis

Cite this article

WANG Jingyu , HU Tieying , CHEN Cheng , ZHANG Li , ZHANG Yubin , MA Guoyuan , LI Aixia , SHI Xixiong . Research progress in biological characteristics of Smac and its regulating IAPs to promote apoptosis[J]. Food and Fermentation Industries, 2025 , 51(10) : 352 -359 . DOI: 10.13995/j.cnki.11-1802/ts.040737

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