Effect of Lactiplantibacillus plantarum CCFM8661 on improving immunity in mice

  • MA Weiwei ,
  • WU Yanan ,
  • ZHAO Yiyang ,
  • SUN Hang ,
  • HUANG Lili
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  • (School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150000, China)

Received date: 2024-05-24

  Revised date: 2024-09-28

  Online published: 2025-08-04

Abstract

To study the modulating effect of Lactiplantibacillus plantarum CCFM8661 on immunity in mice.The 60 mice were randomly divided into five groups:control group, model group, and L.plantarum CCFM8661 low, medium, and high dose groups (1.5×106, 1.5×107, and 1.5×108 CFU/mouse).Except for the control group, an immunosuppression model was established for the remaining groups by injecting cyclophosphamide prior to the experiment, and then the mice in the experimental groups were given different doses of L.plantarum CCFM8661 by gavage.To determine the effects of different doses of L.plantarum CCFM8661 on body mass, immune organ index, cellular immunity, humoral immunity, and non-specific immunity in mice.The results showed that L.plantarum CCFM8661 was able to significantly increase the body mass, thymic index and splenic index of immunosuppressed mice, and regulate cellular immunity, humoral immunity and non-specific immunity of mice.The results showed that L.plantarum CCFM8661 has the function of enhancing immunity in mice.

Cite this article

MA Weiwei , WU Yanan , ZHAO Yiyang , SUN Hang , HUANG Lili . Effect of Lactiplantibacillus plantarum CCFM8661 on improving immunity in mice[J]. Food and Fermentation Industries, 2025 , 51(13) : 75 -82 . DOI: 10.13995/j.cnki.11-1802/ts.039991

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