Cell biology studies the cellular structure, functions and fundamental life processes of organisms.As a fundamental course, cell biology is widely offered in applied disciplines such as biomedical science, food science and engineering, and fermentation engineering.To meet the demand for cultivating innovative professionals in the context of new engineering, the study focus on researching innovative integration in the teaching reforming for cell biology course by combining teaching implementation strategies of cell biology with interdisciplinary practices in applied engineering disciplines such as food science and engineering.In response to the issues of ‘lots of content and difficulty to memorize', ‘boring classroom and poor interaction', ‘emphasis on theory and neglect of practice', ‘lack of cutting-edge information and outdated content', and ‘emphasis on final exams and neglect of the process' in traditional teaching method, a new teaching and reforming model for the cell biology course consisting of five modules was provided, including ‘mind map-based classroom teaching method', ‘multi-media platform-based interactive teaching method', ‘project-oriented innovative practice method', ‘group discussion-based cutting-edge tracking method', and ‘six-dimensional diversified teaching evaluation method'.The teaching reforming model would provide a guidance for the cultivation of interdisciplinary innovative talents.