Food and Fermentation Industries >

2025 , Vol. 51 >Issue 16: 182 - 189

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.040607

Protective effects of fermented wheat bran on dextran sodium sulfate-induced ulcerative colitis in mice

  • DENG Juanli ,
  • DU Wen ,
  • ZHAN Qingyu ,
  • LI Yifan ,
  • SUN Changpo ,
  • LI Tiantian
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  • 1(College of Food Science and Engineering, Henan University of Technology, Zhengzhou 450001 China)
    2(Institute of Cereal and Oil Science and Technology, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China)
    3(College of Resources and Environmental Sciences, China Agricultural University, Beijing 100091, China)
    4(College of Humanities and Urban-Rural Development, Beijing University of Agriculture, Beijing 102206, China)
    5(Standard Quality Center of National Food and Strategic Reserves Administration, Beijing 100834, China)

Received date: 2024-07-30

  Revised date: 2024-12-04

  Online published: 2025-08-29

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Abstract

In this study, 3% dextran sodium sulfate (DSS) was used to establish ulcerative colitis (UC) mouse model to investigate the protective effect of fermented wheat bran (FWB) on ulcerative colitis and its impact on the gut microbiota.Twelve-week-old female BALB/c mice were randomly divided into control, DSS, FWB, and FWB+DSS groups for 14 days.Body weights and feed intake were recorded, and changes in colonic histopathology, plasma inflammatory factors, and intestinal flora were detected.Compared with the DSS group, FWB could effectively alleviate the symptoms of ulcerative colitis and reduce the pathological damage to colon tissue and it also inhibited the expression of inflammatory factors IL-1β (P＜0.01) and TNF-α (P＜0.01).Fecal 16S rRNA sequencing results showed that FWB improved the dysbiosis of the gut microbiota caused by ulcerative colitis and increased the diversity of the gut microbiota and the correlation analysis between gut microbiota and inflammatory cytokines indicated that the levels of IL-1β, TNF-α, and IL-6 in the plasma of ulcerative colitis mice were significantly correlated with the abundance of Escherichia-Shigella and Romboutsia.In conclusion, FWB can alleviate the symptoms of ulcerative colitis in mice and reduce the levels of pro-inflammatory cytokines, and its mechanism is related to the regulation of gut microbiota, inhibition of harmful bacteria, and promotion of the growth of beneficial bacteria.

Key words： fermented wheat bran; ulcerative colitis; intestinal flora; inflammatory factors; protective effects

Cite this article

DENG Juanli , DU Wen , ZHAN Qingyu , LI Yifan , SUN Changpo , LI Tiantian . Protective effects of fermented wheat bran on dextran sodium sulfate-induced ulcerative colitis in mice[J]. Food and Fermentation Industries, 2025 , 51(16) : 182 -189 . DOI: 10.13995/j.cnki.11-1802/ts.040607

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