Food and Fermentation Industries >

2025 , Vol. 51 >Issue 17: 118 - 127

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.041111

Alcohololytic effect of low-viscosity konjac glucomannan in mice with acute alcohol intoxication

  • CHEN Hong ,
  • LIU Dingyu ,
  • DU Yuming ,
  • ZHONG Geng
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  • 1(College of Food Science, Southwest University, Chongqing 400715, China)
    2(Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Chongqing 400716, China)

Received date: 2024-09-22

  Revised date: 2024-12-17

  Online published: 2025-09-29

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Abstract

To investigate the protective effects of low-viscosity konjac glucomannan (LVKGM) on acute alcohol intoxication in mice, konjac glucomannan (KGM) powder was used as the raw material.LVKGM was prepared using microwave-assisted hydrogen peroxide (semi-dry method).C57BL mice served as the animal model, with KGM as the positive control.Behavioral observations, biochemical assessments, and pathological examinations were conducted to evaluate effects of LVKGM on alcohol metabolism and intoxication protection in acute alcohol intoxicated mice, revealing potential mechanisms of action.The results indicated that LVKGM reduced serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in acute alcohol intoxicated mice.LVKGM downregulated the expression of inflammatory factors such as TNF-α in the liver, alleviating the inflammatory response.Additionally, LVKGM enhanced the activity of alcohol dehydrogenase (ADH) in the liver, accelerating alcohol metabolism.It also increased the activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), thereby strengthening antioxidant defense of the liver.Furthermore, LVKGM raised the concentration of short-chain fatty acids (SCFAs) in the colonic contents of alcohol-intoxicated mice and improved cecal microbiota diversity, effectively mitigating the damage caused by acute alcohol intoxication.In conclusion, LVKGM prepared by the microwave-assisted hydrogen peroxide method demonstrated significant protective effects against acute alcohol damage in mice.The findings suggested that these effects may be related to the improvement of gut-liver axis function, restoration of gut barrier integrity, and modulation of gut microbiota and inflammatory responses.This research provides new experimental evidence for the potential use of LVKGM as a therapeutic food for acute alcohol poisoning and daily liver and gastric protection during alcohol consumption.

Key words： konjac glucomannan; low viscosity; acute alcohol intoxication; detoxification and liver protection

Cite this article

CHEN Hong , LIU Dingyu , DU Yuming , ZHONG Geng . Alcohololytic effect of low-viscosity konjac glucomannan in mice with acute alcohol intoxication[J]. Food and Fermentation Industries, 2025 , 51(17) : 118 -127 . DOI: 10.13995/j.cnki.11-1802/ts.041111

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