Effect evaluation of brown rice ferments on intestinal health and its mechanism

  • MENG Fantong ,
  • WANG Mohan ,
  • MA Xishan ,
  • ZHANG Lu ,
  • CAO Qiuge ,
  • HAO Xiyu ,
  • LIU Shiwei ,
  • ZHENG Xiaoyang ,
  • YUAN Peng ,
  • WANG Xue ,
  • LIU Jia
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  • 1(Heilongjiang Beiwei 47 Plant Protein Co., Ltd., Qiqihar 161002, China)
    2(China National Research Institute of Food and Fermentation Industries Co.Ltd., Beijing 100015, China)

Received date: 2024-09-02

  Revised date: 2025-01-13

  Online published: 2025-10-16

Abstract

This study explored the regulatory effect of brown rice ferments on intestinal health and its mechanism based on non-targeted metabolomics, zebrafish constipation model, and in vitro simulated colon anaerobic fermentation, to find the potential functional substances that might be beneficial to intestinal health after fermentation of brown rice and the mechanism to improve intestinal motility.Then, the study evaluated the effects of brown rice ferments on the composition and structure of human intestinal microorganisms.Results showed that there were significant differences in the metabolism of brown rice after fermentation treatment (P<0.05), and there were potential functional substances to improve intestinal health.By down-regulating the expressions of nos1, nos2a, and nos2b genes in constipated zebrafish, brown rice ferments could increase the clearance rate of nitric oxidein, thus effectively promoting the intestinal motility of zebrafish.By regulating the composition structure of human intestinal flora, brown rice ferments could enrich the composition of human intestinal microbes.Therefore, brown rice ferments have a positive effect on intestinal health and will be a promising dietary intervention strategy.

Cite this article

MENG Fantong , WANG Mohan , MA Xishan , ZHANG Lu , CAO Qiuge , HAO Xiyu , LIU Shiwei , ZHENG Xiaoyang , YUAN Peng , WANG Xue , LIU Jia . Effect evaluation of brown rice ferments on intestinal health and its mechanism[J]. Food and Fermentation Industries, 2025 , 51(18) : 304 -312 . DOI: 10.13995/j.cnki.11-1802/ts.040936

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