The application of biological fermented wheat embryo extract in the fields of food, feed, and medicine has garnered extensive attention.Currently, systematic studies on the regulatory effect of biotransformed wheat embryo on human health remain extremely limited.In this study, the antioxidant performance and untargeted metabolome of the fermented wheat embryo extract were comprehensively evaluated.Additionally, the impacts on the survival, exercise capacity, oxidative stress status, and intestinal metabolic environment of Drosophila melanogaster under the stimulation of a low-oxygen environment were investigated.The results demonstrated that lactic acid bacteria enhanced the antioxidant potential of the system by increasing metabolites such as glutathione (8.2 mg/100 mL to 34.6 mg/100 mL) through biotransformation.As a dietary supplement, the increased abundance of nucleotides, amines, purines, and alkaloids, which were involved in energy metabolism, signal transduction, and immune response, might contribute to the improvement of exercise capacity (85.2% to 90.2%), oxidative stress state (DPPH free radical 20.3% to 42%;ABTS cation free radical 0.07 mmol/g to 0.45 mmol/g) and the survival rate (70.8% to 86.7%).Therefore, the wheat germ extracts fermented by lactic acid bacteria have the potential to improve the hypoxia tolerance of the organism.This research provides a scientific foundation for the application of lactic acid bacteria in alleviating the oxidative stress induced by hypoxia.
QI Chenghui
,
LI Qinli
,
LIU Yuan
,
MENG Xianglong
,
LIU Zhenguo
,
HAO Yu
,
MA Yiying
,
KONG Qingmin
,
FAN Zhexin
,
HAN Miao
. Antioxidative properties of fermented wheat germ extracts and its regulation of hypoxia tolerance in Drosophila melanogaster[J]. Food and Fermentation Industries, 2025
, 51(19)
: 17
-25
.
DOI: 10.13995/j.cnki.11-1802/ts.042391
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