Food and Fermentation Industries >

2025 , Vol. 51 >Issue 19: 394 - 402

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.041795

Progress in probiotic fermentation strategies for the microbiota-gut-brain axis

  • JING Sisi ,
  • LI Shuwei ,
  • FU Rongzhan ,
  • ZHU Feng ,
  • LIU Yaping ,
  • LI Hongxia ,
  • HE Shuixiang ,
  • TIAN Wanyi ,
  • FAN Daidi ,
  • FEI Qiang
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  • 1(School of Chemical Engineering and Technology, Xi’an Jiaotong University, Xi’an 710049, China)
    2(Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China)
    3(School of Chemical Engineering, Northwest University, Xi’an 710069, China)
    4(Department of Translational Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China)
    5(Clinical Medical Research Center for Digestive Diseases of Shaanxi Province(Oncology), Xi’an 710061, China)
    6(College of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China)

Received date: 2024-12-07

  Revised date: 2025-03-20

  Online published: 2025-11-03

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Abstract

As our understanding of the mechanisms by which probiotics influence neuropsychiatric disorders through the microbiota-gut-brain axis (MGBA) deepens, there is an increasing interest among clinical researchers in developing probiotic-based therapies.The MGBA functions as a bidirectional communication network, with its efficacy relying on the coordinated interactions among gut microbiota, the neuroendocrine system, and immune regulation.Research has demonstrated that probiotics can impact brain health through various mechanisms, including modulation of neurotransmitter synthesis, regulation of immune-inflammatory factors, and maintenance of gut barrier integrity.However, current probiotic fermentation technologies face challenges such as high costs and operational complexity, limiting their widespread clinical application.This review first explores the mechanisms of action of probiotics within the MGBA and summarizes recent advances in research on their therapeutic potential for neuropsychiatric disorders.Additionally, to address the barriers posed by low production efficiency in probiotic applications, we outline several strategies aimed at optimizing fermentation processes.Finally, in light of the often-suboptimal therapeutic effects of probiotic formulations, we propose multiple feasible strategies for enhancing their efficacy, providing new insights and directions for the development of high-concentration and effective probiotic products.

Key words： probiotics; microbiota-gut-brain axis; neuropsychiatric disorders; fermentation process optimization; probiotic efficacy optimization

Cite this article

JING Sisi , LI Shuwei , FU Rongzhan , ZHU Feng , LIU Yaping , LI Hongxia , HE Shuixiang , TIAN Wanyi , FAN Daidi , FEI Qiang . Progress in probiotic fermentation strategies for the microbiota-gut-brain axis[J]. Food and Fermentation Industries, 2025 , 51(19) : 394 -402 . DOI: 10.13995/j.cnki.11-1802/ts.041795

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