As an endogenous lipid antioxidant, the properties of coenzyme Q10, such as its high molecular weight, strong hydrophobicity, and polycrystalline shape, lead to its exogenous supplementation being greatly restricted.To solve the problem of low bioaccessibility of coenzyme Q10, coenzyme Q10 nanostructured lipid carriers were prepared using monoacylglyceride as an emulsifier and regulating coenzyme Q10 crystals by adjusting the solid-liquid lipid ratio, their physicochemical properties were characterized and the effects of crystal modification on stability and bioaccessibility were investigated.Results showed that the physical stability of the nanostructured lipid carriers was significantly enhanced with the increase of the proportion of chain triglycerides in liquid lipids and the decrease of the crystallinity of the lipid phase (P<0.05), among them, P1/M2, with the advantages of stability, release characteristics, and crystal modification, achieved a bioaccessibility of coenzyme Q10 in simulated in vitro digestion of (72.1±2.5)%, which was significantly higher than that of other lipid carriers (P＜0.05).In conclusion, the regulation of coenzyme Q10 crystal growth through the lipid phase effectively improved its bioaccessibility and provided a theoretical basis and technical support for the development of functional products of other fat-soluble active ingredients.
ZHU Mengjie
,
FANG Suqiong
,
XU Jun
,
WU Jian
,
MIAO Jinyu
,
MA Li
,
LIU Wei
,
ZOU Liqiang
. Preparation, characterization and study on bioaccessibility improvement of crystal-modified coenzyme Q10 nanostructured lipid carriers[J]. Food and Fermentation Industries, 2025
, 51(21)
: 270
-276
.
DOI: 10.13995/j.cnki.11-1802/ts.041950
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